HIV-1-Specific CAR-T Cells With Cell-Intrinsic PD-1 Checkpoint Blockade Enhance Anti-HIV Efficacy in vivo

HIV-1-Specific Chimeric Antigen Receptor T Cells Fail To Recognize and Eliminate the Follicular Dendritic Cell HIV Reservoir In Vitro

(2020) Matthew T. Ollerton et al.   JOURNAL OF VIROLOGY

Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

(2020) Colby R. Maldini et al.   NATURE MEDICINE

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

(2019) Kim Anthony-Gonda et al.   Science Translational Medicine

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform

(2019) Eytan Herzig et al.   CELL

Development of CAR-T cells for long-term eradication and surveillance of HIV-1 reservoir

(2019) Bingfeng Liu et al.   Current Opinion in Virology

Chimeric antigen receptor T-cell approaches to HIV cure

(2018) Anne-Sophie Kuhlmann et al.   Current Opinion in HIV and AIDS

Quarter Century of Anti-HIV CAR T Cells

(2018) Thor A. Wagner   Current HIV/AIDS Reports

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

(2018) Sarwish Rafiq et al.   NATURE BIOTECHNOLOGY

Identification and specificity of broadly neutralizing antibodies against HIV

(2017) Laura E. McCoy et al.   IMMUNOLOGICAL REVIEWS

In Vivo Models of Human Immunodeficiency Virus Persistence and Cure Strategies

(2017) Christopher C. Nixon et al.   JOURNAL OF INFECTIOUS DISEASES

Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection

(2017) Jeffrey E. Teigler et al.   JOURNAL OF VIROLOGY

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy

(2017) Nan Chen et al.   OncoImmunology

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

(2016) Leonid Cherkassky et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies

(2016) Ayub Ali et al.   JOURNAL OF VIROLOGY

Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4 + T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppressive Combined Antiretroviral Therapy

(2016) Bingfeng Liu et al.   JOURNAL OF VIROLOGY

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART

(2016) Rémi Fromentin et al.   PLoS Pathogens

HIV-1 functional cure: will the dream come true?

(2015) Chao Liu et al.   BMC Medicine

The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects

(2015) Xiaoling Tian et al.   JOURNAL OF IMMUNOLOGY

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells

(2014) Patricia Graef et al.   IMMUNITY

Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1

(2014) Janet D. Siliciano et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eradicating HIV-1 infection: seeking to clear a persistent pathogen

(2014) Nancie M. Archin et al.   NATURE REVIEWS MICROBIOLOGY

An Integrated Overview of HIV-1 Latency

(2013) Debbie S. Ruelas et al.   CELL

The Weal and Woe of Costimulation in the Adoptive Therapy of Cancer with Chimeric Antigen Receptor (CAR)-Redirected T Cells

(2013) A. Hombach et al.   CURRENT MOLECULAR MEDICINE

Differential Impact of PD-1 and/or Interleukin-10 Blockade on HIV-1-Specific CD4 T Cell and Antigen-Presenting Cell Functions

(2013) F. Porichis et al.   JOURNAL OF VIROLOGY

Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

(2013) Christine Katlama et al.   LANCET

Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells

(2013) Gautam K. Sahu et al.   VIROLOGY

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo

(2011) A. G. Chapuis et al.   BLOOD

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

HIV-specific CD4 T cells and immune control of viral replication

(2011) Filippos Porichis et al.   Current Opinion in HIV and AIDS

Role of PD-1 in HIV Pathogenesis and as Target for Therapy

(2011) Filippos Porichis et al.   Current HIV/AIDS Reports

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8 + T Cell Clones in Rhesus Macaques during Acute Infection

(2009) Jacob T. Minang et al.   JOURNAL OF IMMUNOLOGY

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

(2009) Robert H Kutner et al.   Nature Protocols

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Interleukin‐4–Transgenic hu‐PBL‐SCID Mice: A Model for the Screening of Antiviral Drugs and Immunotherapeutic Agents against X4 HIV‐1 Viruses

(2007) Kazu Okuma et al.   JOURNAL OF INFECTIOUS DISEASES