HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia

(2020) Ryo Miyamoto et al.   Cell Reports

The Enigmatic HOX Genes: Can We Crack Their Code?

(2019) Zhifei Luo et al.   Cancers

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis

(2018) Yuqing Sun et al.   CANCER CELL

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia

(2017) Hiroshi Okuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish

(2017) J-W Lu et al.   Blood Cancer Journal

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia

(2016) Shan Lin et al.   CANCER CELL

HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

(2016) M Kontro et al.   LEUKEMIA

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

(2016) Konstantinos Tzelepis et al.   Cell Reports

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

(2015) Anna K Andersson et al.   NATURE GENETICS

Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets

(2015) C T Collins et al.   ONCOGENE

AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription

(2015) Hiroshi Okuda et al.   Nature Communications

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

(2015) Gabriela Brumatti et al.   Oncotarget

Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation

(2014) J Steger et al.   LEUKEMIA

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

(2014) Dirk Heckl et al.   NATURE BIOTECHNOLOGY

MYC and the Control of Apoptosis

(2014) S. B. McMahon   Cold Spring Harbor Perspectives in Medicine

Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia

(2013) Hong Zhang et al.   CANCER CELL

MLL Becomes Functional through Intra-Molecular Interaction Not by Proteolytic Processing

(2013) Akihiko Yokoyama et al.   PLoS One

Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

(2013) R. Pan et al.   Cancer Discovery

DAVID-WS: a stateful web service to facilitate gene/protein list analysis

(2012) X. Jiao et al.   BIOINFORMATICS

SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia

(2012) P. Ramezani-Rad et al.   BLOOD

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Identification and characterization of Hoxa9 binding sites in hematopoietic cells

(2011) Y. Huang et al.   BLOOD

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

(2011) Hongkai Ji et al.   PLoS One

A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription

(2010) Akihiko Yokoyama et al.   CANCER CELL

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group

(2010) Torsten Haferlach et al.   JOURNAL OF CLINICAL ONCOLOGY

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family

(2009) L J Beverly et al.   ONCOGENE

Regeneration, repair and remembering identity: the three Rs of Hox gene expression

(2009) Kevin C. Wang et al.   TRENDS IN CELL BIOLOGY

Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences

(2008) Michael F. Berger et al.   CELL

Exploration of Human ORFeome: High-Throughput Preparation of ORF Clones and Efficient Characterization of Their Protein Products

(2008) T. Nagase et al.   DNA RESEARCH