Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics

(2020) Chunfang Xie et al.   Toxins

Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite

(2020) Laura-Oana Albulescu et al.   Science Translational Medicine

Causes and Consequences of Snake Venom Variation

(2020) Nicholas R. Casewell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A pan-specific antiserum produced by a novel immunization strategy shows a high spectrum of neutralization against neurotoxic snake venoms

(2020) Kavi Ratanabanangkoon et al.   Scientific Reports

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management

(2020) Stuart Ainsworth et al.   PLoS Neglected Tropical Diseases

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

(2020) Cecilie Knudsen et al.   Toxins

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

(2020) Laura-Oana Albulescu et al.   Nature Communications

Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming

(2019) David J. Williams et al.   PLoS Neglected Tropical Diseases

Evaluation of the geographical utility of Eastern Russell’s viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity

(2019) Janeyuth Chaisakul et al.   PLoS Neglected Tropical Diseases

Beyond the ‘big four’: Venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies

(2019) R. R. Senji Laxme et al.   PLoS Neglected Tropical Diseases

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms

(2018) Stuart Ainsworth et al.   Journal of Proteomics

Innovative Immunization Strategies for Antivenom Development

(2018) Erick Bermúdez-Méndez et al.   Toxins

Synthetic peptide antigens derived from long-chain alpha-neurotoxins: Immunogenicity effect against elapid venoms

(2017) Guillermo de la Rosa et al.   PEPTIDES

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa

(2017) Robert A. Harrison et al.   PLoS Neglected Tropical Diseases

Multipurpose HTS Coagulation Analysis: Assay Development and Assessment of Coagulopathic Snake Venoms

(2017) Kristina Still et al.   Toxins

A Review and Database of Snake Venom Proteomes

(2017) Theo Tasoulis et al.   Toxins

Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest

(2016) Larissa Gonçalves-Machado et al.   Journal of Proteomics

Toxicovenomics and antivenom profiling of the Eastern green mamba snake ( Dendroaspis angusticeps )

(2016) Line P. Lauridsen et al.   Journal of Proteomics

Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom

(2016) Mauren Villalta et al.   TOXICON

A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia

(2016) Kavi Ratanabanangkoon et al.   PLoS Neglected Tropical Diseases

Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding

(2016) José Gutiérrez et al.   Toxins

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

(2016) José Gutiérrez et al.   Toxins

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development

(2015) Andreas H. Laustsen et al.   Journal of Proteomics

Current Treatment for Venom-Induced Consumption Coagulopathy Resulting from Snakebite

(2014) Kalana Maduwage et al.   PLoS Neglected Tropical Diseases

Immunological Cross-Reactivity and Neutralisation of European Viper Venoms with the Monospecific Vipera berus Antivenom ViperaTAb

(2014) Nicholas Casewell et al.   Toxins

Diagnostic 20-min whole blood clotting test in Russell's viper envenoming delays antivenom administration

(2013) G. K. Isbister et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Snake venomics: From the inventory of toxins to biology

(2013) Juan J. Calvete   TOXICON

A Randomised Controlled Trial of Two Infusion Rates to Decrease Reactions to Antivenom

(2012) Geoffrey K. Isbister et al.   PLoS One

Cross Neutralization of Afro-Asian Cobra and Asian Krait Venoms by a Thai Polyvalent Snake Antivenom (Neuro Polyvalent Snake Antivenom)

(2012) Poh Kuan Leong et al.   PLoS Neglected Tropical Diseases

Research strategies to improve snakebite treatment: Challenges and progress

(2011) Robert A. Harrison et al.   Journal of Proteomics

Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

(2011) David J. Williams et al.   Journal of Proteomics

Low-Dose Adrenaline, Promethazine, and Hydrocortisone in the Prevention of Acute Adverse Reactions to Antivenom following Snakebite: A Randomised, Double-Blind, Placebo-Controlled Trial

(2011) H. Asita de Silva et al.   PLOS MEDICINE

Snakebite Doesn't Cause Disseminated Intravascular Coagulation: Coagulopathy and Thrombotic Microangiopathy in Snake Envenoming

(2010) Geoffrey Isbister   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Randomised Controlled Double-Blind Non-Inferiority Trial of Two Antivenoms for Saw-Scaled or Carpet Viper (Echis ocellatus) Envenoming in Nigeria

(2010) Isa S. Abubakar et al.   PLoS Neglected Tropical Diseases

Pre-Clinical Assays Predict Pan-African Echis Viper Efficacy for a Species-Specific Antivenom

(2010) Nicholas R. Casewell et al.   PLoS Neglected Tropical Diseases

Venoms, venomics, antivenomics

(2009) Juan J. Calvete et al.   FEBS LETTERS

Failure of antivenom to improve recovery in Australian snakebite coagulopathy

(2009) G.K. Isbister et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Procoagulant Snake Toxins: Laboratory Studies, Diagnosis, and Understanding Snakebite Coagulopathy

(2009) Geoffrey Isbister   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Snake Venomics of the Lesser Antillean Pit VipersBothrops caribbaeusandBothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom†

(2008) José María Gutiérrez et al.   JOURNAL OF PROTEOME RESEARCH

Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii

(2008) Bruno Lomonte et al.   JOURNAL OF PROTEOME RESEARCH

The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and Deaths

(2008) Anuradhani Kasturiratne et al.   PLOS MEDICINE