Future considerations for the mRNA-lipid nanoparticle vaccine platform

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2

(2021) Kimberly G. Blumenthal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus

(2020) Seiki Shirai et al.   Frontiers in Immunology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Lipid nanoparticles for nucleic acid delivery: Current perspectives

(2020) Eleni Samaridou et al.   ADVANCED DRUG DELIVERY REVIEWS

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

(2020) Gergely Tibor Kozma et al.   ADVANCED DRUG DELIVERY REVIEWS

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

A vaccine combination of lipid nanoparticles and a cholera toxin adjuvant derivative greatly improves lung protection against influenza virus infection

(2020) Valentina Bernasconi et al.   Mucosal Immunology

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

(2019) Marios Koutsakos et al.   NATURE IMMUNOLOGY

A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells

(2019) Jessica Schulze et al.   BIOCHEMISTRY

Antigen presentation by dendritic cells for B cell activation

(2019) William R Heath et al.   CURRENT OPINION IN IMMUNOLOGY

Therapeutic mRNA delivery to leukocytes

(2019) Yasmin Granot-Matok et al.   JOURNAL OF CONTROLLED RELEASE

DC Subsets Regulate Humoral Immune Responses by Supporting the Differentiation of Distinct Tfh Cells

(2019) Aurélie Bouteau et al.   Frontiers in Immunology

Three decades of messenger RNA vaccine development

(2019) Rein Verbeke et al.   Nano Today

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

“Double-duty” conventional dendritic cells in the amphibian Xenopus as the prototype for antigen presentation to B cells

(2018) Harold R. Neely et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

(2018) Norbert Pardi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens

(2016) Gokul Swaminathan et al.   VACCINE

A Tetravalent Sub-unit Dengue Vaccine Formulated with Ionizable Cationic Lipid Nanoparticle induces Significant Immune Responses in Rodents and Non-Human Primates

(2016) Gokul Swaminathan et al.   Scientific Reports

Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates

(2015) Jessica Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Skin dendritic cells induce follicular helper T cells and protective humoral immune responses

(2015) Chen Yao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

mRNA-based dendritic cell vaccines

(2014) Daphné Benteyn et al.   Expert Review of Vaccines

Complement activation-related pseudoallergy: A stress reaction in blood triggered by nanomedicines and biologicals

(2014) Janos Szebeni   MOLECULAR IMMUNOLOGY

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways

(2013) Caroline Lonez et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cationic lipids activate intracellular signaling pathways

(2012) Caroline Lonez et al.   ADVANCED DRUG DELIVERY REVIEWS

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy

(2010) Nikolaus Romani et al.   IMMUNOLOGY AND CELL BIOLOGY

DiC14-amidine cationic liposomes stimulate myeloid dendritic cells through Toll-like receptor 4

(2008) Tetsuya Tanaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

(2008) Hekla Sigmundsdottir et al.   NATURE IMMUNOLOGY