Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer
Published 2021 View Full Article
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Title
Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer
Authors
Keywords
SPOP, SPOPL, AR, neoadjuvant androgen pathway inhibition, TP53, PTEN, TGF-β, phylogenetics, whole exome sequencing, RNA-seq
Journal
Cell Reports
Volume 36, Issue 10, Pages 109665
Publisher
Elsevier BV
Online
2021-09-07
DOI
10.1016/j.celrep.2021.109665
References
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Note: Only part of the references are listed.- Transcriptional mediators of treatment resistance in lethal prostate cancer
- (2021) Meng Xiao He et al. NATURE MEDICINE
- Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer
- (2021) Tiziano Bernasocchi et al. Nature Communications
- Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy
- (2021) Scott Wilkinson et al. EUROPEAN UROLOGY
- Ipatasertib plus abiraterone and prednisolone in metastatic castration-resistant prostate cancer (IPATential150): a multicentre, randomised, double-blind, phase 3 trial
- (2021) Christopher Sweeney et al. LANCET
- Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity
- (2021) Ivana Grbesa et al. Cell Reports
- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Detection of molecular signatures of homologous recombination deficiency in prostate cancer with or without BRCA1/2 mutations
- (2020) Zsofia Sztupinszki et al. CLINICAL CANCER RESEARCH
- The repertoire of mutational signatures in human cancer
- (2020) Ludmil B. Alexandrov et al. NATURE
- A case report of multiple primary prostate tumors with differential drug sensitivity
- (2020) Scott Wilkinson et al. Nature Communications
- Olaparib for Metastatic Castration-Resistant Prostate Cancer
- (2020) Johann de Bono et al. NEW ENGLAND JOURNAL OF MEDICINE
- CoMut: visualizing integrated molecular information with comutation plots
- (2020) Jett Crowdis et al. BIOINFORMATICS
- Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer
- (2020) Umang Swami et al. EUROPEAN UROLOGY
- Evaluation of Intense Androgen Deprivation Before Prostatectomy: A Randomized Phase II Trial of Enzalutamide and Leuprolide With or Without Abiraterone
- (2019) Rana R. McKay et al. JOURNAL OF CLINICAL ONCOLOGY
- The Proteogenomic Landscape of Curable Prostate Cancer
- (2019) Ankit Sinha et al. CANCER CELL
- Growth dynamics in naturally progressing chronic lymphocytic leukaemia
- (2019) Michaela Gruber et al. NATURE
- Detecting the mutational signature of homologous recombination deficiency in clinical samples
- (2019) Doga C. Gulhan et al. NATURE GENETICS
- Genomic correlates of clinical outcome in advanced prostate cancer
- (2019) Wassim Abida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer
- (2019) Abhijit Parolia et al. NATURE
- Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer
- (2019) Ian D. Davis et al. NEW ENGLAND JOURNAL OF MEDICINE
- Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer
- (2019) Kim N. Chi et al. NEW ENGLAND JOURNAL OF MEDICINE
- The ubiquitin ligase adaptor SPOP in cancer
- (2019) Matthew J. Cuneo et al. FEBS Journal
- Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer
- (2019) Mark P. Labrecque et al. JOURNAL OF CLINICAL INVESTIGATION
- Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline
- (2019) Scott E. Eggener et al. JOURNAL OF CLINICAL ONCOLOGY
- Neoadjuvant-intensive androgen deprivation therapy selects for prostate tumor foci with diverse subclonal oncogenic alterations
- (2018) Adam G. Sowalsky et al. CANCER RESEARCH
- The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression
- (2018) Shadrielle Melijah G. Espiritu et al. CELL
- DeTiN: overcoming tumor-in-normal contamination
- (2018) Amaro Taylor-Weiner et al. NATURE METHODS
- Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer
- (2018) Maha Hussain et al. NEW ENGLAND JOURNAL OF MEDICINE
- Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
- (2018) Matthew R. Smith et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
- (2018) Marthe Løvf et al. EUROPEAN UROLOGY
- A universal SNP and small-indel variant caller using deep neural networks
- (2018) Ryan Poplin et al. NATURE BIOTECHNOLOGY
- SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability
- (2018) Kim Hjorth-Jensen et al. NUCLEIC ACIDS RESEARCH
- TGF-β receptor I inhibitor enhances response to enzalutamide in a pre-clinical model of advanced prostate cancer
- (2018) Channing Paller et al. PROSTATE
- The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT)
- (2018) Oluwadamilola M. Fayanju et al. ANNALS OF SURGERY
- Systematic Review of Systemic Therapies and Therapeutic Combinations with Local Treatments for High-risk Localized Prostate Cancer
- (2018) Lorenzo Tosco et al. EUROPEAN UROLOGY
- COSMIC: the Catalogue Of Somatic Mutations In Cancer
- (2018) John G Tate et al. NUCLEIC ACIDS RESEARCH
- Intratumoral and Intertumoral Genomic Heterogeneity of Multifocal Localized Prostate Cancer Impacts Molecular Classifications and Genomic Prognosticators
- (2017) Lei Wei et al. EUROPEAN UROLOGY
- Genomic hallmarks of localized, non-indolent prostate cancer
- (2017) Michael Fraser et al. NATURE
- Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer
- (2017) Karim Fizazi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy
- (2017) Nicholas D. James et al. NEW ENGLAND JOURNAL OF MEDICINE
- Post prostatectomy outcomes of patients with high-risk prostate cancer treated with neoadjuvant androgen blockade
- (2017) Rana R. McKay et al. PROSTATE CANCER AND PROSTATIC DISEASES
- Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer
- (2016) M. L. Telli et al. CLINICAL CANCER RESEARCH
- 5-year analysis of neoadjuvant pertuzumab and trastuzumab in patients with locally advanced, inflammatory, or early-stage HER2-positive breast cancer (NeoSphere): a multicentre, open-label, phase 2 randomised trial
- (2016) Luca Gianni et al. LANCET ONCOLOGY
- FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing
- (2016) Ronglai Shen et al. NUCLEIC ACIDS RESEARCH
- The Molecular Taxonomy of Primary Prostate Cancer
- (2015) Adam Abeshouse et al. CELL
- A Genomic Classifier Improves Prediction of Metastatic Disease Within 5 Years After Surgery in Node-negative High-risk Prostate Cancer Patients Managed by Radical Prostatectomy Without Adjuvant Therapy
- (2015) Eric A. Klein et al. EUROPEAN UROLOGY
- Spatial genomic heterogeneity within localized, multifocal prostate cancer
- (2015) Paul C Boutros et al. NATURE GENETICS
- SPOP mutation leads to genomic instability in prostate cancer
- (2015) Gunther Boysen et al. eLife
- The Molecular Signatures Database Hallmark Gene Set Collection
- (2015) Arthur Liberzon et al. Cell Systems
- Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins
- (2015) Paula Vainio et al. Oncotarget
- Intense Androgen-Deprivation Therapy With Abiraterone Acetate Plus Leuprolide Acetate in Patients With Localized High-Risk Prostate Cancer: Results of a Randomized Phase II Neoadjuvant Study
- (2014) Mary-Ellen Taplin et al. JOURNAL OF CLINICAL ONCOLOGY
- Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis
- (2014) Patricia Cortazar et al. LANCET
- Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine
- (2014) Eliezer M Van Allen et al. NATURE MEDICINE
- MSIsensor: microsatellite instability detection using paired tumor-normal sequence data
- (2013) Beifang Niu et al. BIOINFORMATICS
- Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer
- (2013) K D Sørensen et al. BRITISH JOURNAL OF CANCER
- Rationale for and Review of Neoadjuvant Therapy Prior to Radical Prostatectomy for Patients with High-Risk Prostate Cancer
- (2013) Rana R. McKay et al. DRUGS
- Correlation of Pathologic Complete Response with Survival After Neoadjuvant Chemotherapy in Bladder Cancer Treated with Cystectomy: A Meta-analysis
- (2013) Fausto Petrelli et al. EUROPEAN UROLOGY
- Mutational heterogeneity in cancer and the search for new cancer-associated genes
- (2013) Michael S. Lawrence et al. NATURE
- Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
- (2013) Kristian Cibulskis et al. NATURE BIOTECHNOLOGY
- Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation
- (2013) Maura Costello et al. NUCLEIC ACIDS RESEARCH
- Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs
- (2012) Christopher T. Saunders et al. BIOINFORMATICS
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Absolute quantification of somatic DNA alterations in human cancer
- (2012) Scott L Carter et al. NATURE BIOTECHNOLOGY
- Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
- (2012) Howard I. Scher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy
- (2012) Charles J. Ryan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation
- (2012) Davis J. McCarthy et al. NUCLEIC ACIDS RESEARCH
- Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase
- (2012) Wesley J. Errington et al. STRUCTURE
- ContEst: estimating cross-contamination of human samples in next-generation sequencing data
- (2011) Kristian Cibulskis et al. BIOINFORMATICS
- RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
- (2011) Bo Li et al. BMC BIOINFORMATICS
- Abiraterone and Increased Survival in Metastatic Prostate Cancer
- (2011) Johann S. de Bono et al. NEW ENGLAND JOURNAL OF MEDICINE
- GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
- (2011) Craig H Mermel et al. GENOME BIOLOGY
- Time Trends and Local Variation in Primary Treatment of Localized Prostate Cancer
- (2010) Matthew R. Cooperberg et al. JOURNAL OF CLINICAL ONCOLOGY
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Prostate Cancer–Specific Mortality After Radical Prostatectomy for Patients Treated in the Prostate-Specific Antigen Era
- (2009) Andrew J. Stephenson et al. JOURNAL OF CLINICAL ONCOLOGY
- Genomic Strategy for Targeting Therapy in Castration-Resistant Prostate Cancer
- (2009) Prateek Mendiratta et al. JOURNAL OF CLINICAL ONCOLOGY
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- (2009) David A. Barbie et al. NATURE
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