Article
Engineering, Biomedical
Panchanathan Manivasagan, Ara Joe, Hyo-Won Han, Thavasyappan Thambi, Manickam Selvaraj, Kumarappan Chidambaram, Jungbae Kim, Eue-Soon Jang
Summary: PT-enhanced Fenton-based CDT is a promising cancer treatment approach that triggers the Fenton or Fenton-like reactions within the tumor microenvironment to generate highly cytotoxic hydroxyl radicals. However, existing CDT therapies are hindered by limitations such as low levels of endogenous hydrogen peroxide and low catalytic efficacy, prompting the combination of photothermal therapy (PTT) to enhance therapeutic efficacy.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Zeming Liu, Hongbo Chen, Chunyu Huang, Qinqin Huang
Summary: A hydrogel-based system loaded with Cu-Hemin-Au composite nanomaterials is designed to enhance oxidative stress and achieve complete inhibition of tumor growth through a synergistic effect of photothermal therapy and chemodynamic therapy.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Huizhu Yu, Ming Ma, Kaicheng Liang, Jie Shen, Zhengyi Lan, Hangrong Chen
Summary: This study successfully fabricated a novel multifunctional nanotherapeutic agent named FeEP-NP using a simple self-assembly method, which can generate toxic hydroxyl radicals for cancer treatment and achieve mild hyperthermia-enhanced chemodynamic therapy through photothermal conversion capabilities. Experimental results demonstrate that this nanotherapeutic agent can effectively suppress tumor growth.
APPLIED MATERIALS TODAY
(2021)
Article
Biophysics
Dihai Gu, Zhikun Liu, Hongshuai Wu, Peijing An, Xu Zhi, Yujie Yin, Wen Liu, Baiwang Sun
Summary: A new nano-platform PBMO-GH for multi-modal therapy was developed in this study, which effectively inhibited the growth of tumor cells through the synergistic effect of ST/CDT/PTT.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Crystallography
Kayalvizhi Samuvel Muthiah, Senthilkumar Thirumurugan, Yu-Chien Lin, Rajalakshmi Sakthivel, Udesh Dhawan, An-Ni Wang, Michael Hsiao, Ren-Jei Chung
Summary: Ce3NbO7/g-C3N4 nanocomposites exhibit synergistic enhancement of cancer treatment by generating cytotoxic reactive oxygen species (ROS) and inducing photothermal therapy (PTT) in the tumor microenvironment.
Article
Materials Science, Multidisciplinary
Tangna Pan, Ke Yang, Jiwei Li, E. Pang, Shaojing Zhao, Xuejian Xing, Qiuxia Tan, Qin Wang, Jianing Yi, Minhuan Lan
Summary: This study successfully achieved synergistic near-infrared light-triggered low-temperature photothermal therapy (LTPTT) and glutathione-activated chemodynamic therapy (CDT) using self-assembled quercetin-Fe3+ nanoparticles (Qu-Fe NPs). Qu-Fe NPs had a wide absorption range and excellent photothermal conversion ability. They could downregulate the expression of heat shock protein 70 through LTPTT and deplete overexpressed GSH through CDT, resulting in synergistic therapeutic effects.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Physical
Kaixin Liao, Boyi Niu, Haibing Dong, Luxuan He, Yixian Zhou, Ying Sun, Dan Yang, Chuanbin Wu, Xin Pan, Guilan Quan
Summary: This study developed a versatile nanomedicine that could effectively treat melanoma by increasing ROS accumulation. The nanomedicine achieved ROS accumulation through mechanisms such as photothermal reaction, glutathione consumption, and mitochondrial dysfunction, leading to oxidative stress and apoptosis of tumor cells. The experimental results demonstrated superior antitumor efficacy and good biosafety of the nanomedicine.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Biomedical
Jiaqi Li, Haina Tian, Fukai Zhu, Suhua Jiang, Maomao He, Yang Li, Qiang Luo, Wen Sun, Xiaolong Liu, Peiyuan Wang
Summary: Intracellular oxidative amplification is effective in destroying tumor cells, but overexpressed glutathione impairs this effect. Researchers have developed a new nanocarrier that enhances tumor chemodynamic therapy by combining photothermal therapy and glutathione depletion.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Zhaoqing Shi, Jing Tang, Chuchu Lin, Ting Chen, Fan Zhang, Yuxing Huang, Ping Luan, Zhuo Xin, Qianqian Li, Lin Mei
Summary: This study developed an iron-mineralized black phosphorene nanosheet as a promising strategy for selective inhibition of tumor cells. The nanosheet showed enhanced cytotoxicity and excellent anti-tumor effects in combination with photothermal therapy.
Review
Biotechnology & Applied Microbiology
Jingqi Xin, Caiting Deng, Omer Aras, Mengjiao Zhou, Chunsheng Wu, Feifei An
Summary: This article discusses the potential of chemodynamic therapy (CDT) based on Fenton and Fenton-like reactions in enhancing anticancer efficacy, including direct killing of cancer cells, indirectly enhancing therapeutic efficacy, and diagnosing and monitoring cancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Engineering, Environmental
Xiunan Wu, Guojun Cao, Han Chen, Weiwei Sheng, Shanrong Lv, Zheng Li, Zetai Bai, Zhiyuan Hua, Zhili Qiu, Minghao Chao, Kaijin Guo, Xin Zheng, Fenglei Gao
Summary: The study explores the use of F-PCP nanoparticles for the treatment of RA, achieving inhibition of macrophage proliferation through in situ oxygen production and chemical reactions, as well as stimulating the reaction through photothermal therapy, showing potential for improving therapeutic outcomes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Houjuan Zhu, Shuyi Huang, Mengbin Ding, Zibiao Li, Jingchao Li, Suhua Wang, David Tai Leong
Summary: This study developed sulfur-deficient engineered cobalt sulfide quantum dots (CoSx QDs) for improved synergistic photothermal- and hyperthermal-enhanced chemodynamic therapy (CDT) of tumors. By modulating the photothermal conversion efficiency and Fenton-like activity, the CoSx QDs exhibited remarkable anticancer properties with favorable biocompatibility. The defect-driven mechanism for the photothermal-enhanced Fenton-like reaction provides a flexible strategy for cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Hongmei Kang, Lamei Chen, Qin Li, Huan Chen, Liangke Zhang
Summary: In this study, a hyaluronic acid-modified ruthenium nanoaggregate and glucose oxidase-loaded manganese dioxide nanoflowers have been prepared. These nanomaterials can generate oxygen in the tumor microenvironment, alleviate tumor tissue hypoxia, and achieve high-temperature ablation of solid tumors. Additionally, they can consume glucose in the presence of oxygen, reduce tumor nutrient supply, and produce cytotoxic hydroxyl radicals, thereby enhancing the antitumor effect. The nanomaterials can also actively target tumor cells, improving the overall therapeutic effect.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Yanhong Sun, Hongda Chen, Ying Huang, Fengqin Xu, Guifeng Liu, Lina Ma, Zhenxin Wang
Summary: The study demonstrates that facile fabrication of Fe-based nanotheranostic agents with enhanced Chemodynamic therapy effects and multiple functions is achievable using a simple redox self-assembly strategy. The core-shell nanoparticles exhibited enhanced production of center dot OH in Fenton reaction when activated, along with a favorable photothermal effect and pH-responsive properties. This work provides an attractive route to prepare versatile nanotheranostic agents for oncotherapy.
Review
Biotechnology & Applied Microbiology
Dhelal F. Mohammed, Hussein A. Madlool, Mohammed Faris, Bashar Hadi Shalan, Huda Hadi Hasan, Nidaa F. Azeez, Fatima Hashim Abbas
Summary: The most important aspect of chemodynamic therapy (CDT) is the utilization of Fenton or Fenton-like chemistry in the tumor microenvironment, which leads to cancer cell death. CDT is considered as a viable cancer therapy modality. This review discusses the recent advancements in CDT and provides some typical examples.
