Article
Nutrition & Dietetics
Takahiro Yajima, Kumiko Yajima, Maiko Arao
Summary: The study analyzed 263 hemodialysis patients and found lower GNRI and mCI were independently associated with all-cause mortality, with the lower group having increased risk compared to the higher group. Simultaneous evaluation of GNRI and mCI can be used to better predict mortality risk in hemodialysis patients.
Article
Nutrition & Dietetics
Yoshikazu Miyasato, Ramy M. Hanna, Jun Morinaga, Masashi Mukoyama, Kamyar Kalantar-Zadeh
Summary: Prognostic nutritional index (PNI), calculated from serum albumin level and total lymphocyte count, is a useful prognostic marker for both cancer patients and patients undergoing hemodialysis.
Article
Medicine, General & Internal
Junko Ishida, Akihiko Kato
Summary: Patients on hemodialysis (HD) are at a higher risk of protein-energy wasting (PEW) due to decreased energy and protein intake and loss of nutrients in the dialysis effluent. Several nutritional screening methods are available, but their use in HD patients varies. Japanese patients on HD have a specific nutritional risk index based on modified PEW criteria. These screening tools help evaluate dietary intake and provide dietary advice, with options including oral supplementation and intradialytic parenteral nutrition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Ming-Tsun Tsai, Shuo-Ming Ou, Huan-Yuan Chen, Wei-Cheng Tseng, Kuo-Hua Lee, Chih-Yu Yang, Ruey-Bing Yang, Der-Cherng Tarng
Summary: Plasma galectin-3 levels are associated with protein-energy wasting in patients undergoing maintenance hemodialysis, but galectin-3 is not superior in predicting PEW compared to other nutritional indicators. Novel biomarkers are needed to detect patients at risk for malnutrition and implement appropriate interventions.
Article
Pharmacology & Pharmacy
Aiya Qin, Jiaxing Tan, Wen Hu, Yuan Liu, Lin Chen, Yi Tang, Wei Qin
Summary: This prospective study investigated the benefits of oral energy supplementation (OES) in hemodialysis patients with protein-energy wasting (PEW). The results showed that OES significantly improved serum albumin, hemoglobin, and dietary energy intake, as well as enhanced nutritional status and quality of life. No electrolyte disorders or dyslipidemia were observed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Lucia Visiedo, Laura Rey, Francisco Rivas, Francisca Lopez, Begona Tortajada, Rafael Gimenez, Jimena Abiles
Summary: Malnutrition is common in hemodialysis patients and can negatively impact quality of life. A nutritional intervention program can improve quality of life by addressing malnutrition in its early stages.
SCIENTIFIC REPORTS
(2022)
Article
Hematology
Shunsuke Yamada, Hokuto Arase, Masatomo Taniguchi, Takanari Kitazono, Toshiaki Nakano
Summary: The study found that the simplified GNRI (sGNRI) is as useful as the original GNRI for screening for malnutrition and stratifying hemodialysis patients at increased mortality risk.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Medicine, General & Internal
Sinee Disthabanchong, Sarunya Saeseow, Sirote Khunapornphairote, Ronnarat Suvikapakornkul, Yodying Wasutit, Jumroon Tungkeeratichai
Summary: Parathyroidectomy is associated with improvement in nutritional status in maintenance hemodialysis patients, especially for those with severe hyperparathyroidism. This finding is crucial as protein-energy wasting is common in kidney failure patients and can have negative impacts on survival and outcomes.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Xiaoling Ye, Jeroen P. Kooman, Frank M. van der Sande, Jochen G. Raimann, Len A. Usvyat, Yuedong Wang, Franklin W. Maddux, Peter Kotanko
Summary: The study found that both low and high phosphate levels were associated with higher risk of mortality across all age strata. Additionally, U-shaped relationships between phosphate levels and outcome persisted even for patients with low or high levels of nutritional and inflammatory markers.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Nutrition & Dietetics
Takayuki Naito, Toshiki Doi, Kenichi Morii, Koji Usui, Michiko Arita, Kazuomi Yamashita, Kenichiro Shigemoto, Yoshiko Nishizawa, Sonoo Mizuiri, Kensuke Sasaki, Takao Masaki
Summary: This study found that the combined estimation of the geriatric nutritional risk index (GNRI) and the modified creatinine index (mCI) provides synergistic information for predicting mortality in patients treated by chronic hemodialysis. The analysis of 499 patients on hemodialysis for five years revealed that patients in the G2 and G4 subgroups had a significantly worse outcome compared to the G1 subgroup. The multivariable-adjusted model showed that only the G4 subgroup was significantly associated with all-cause mortality.
Article
Pediatrics
Ulfat Khadija, Shahid Mahmood, Ammara Ainee, Muhammad Yousaf Quddoos, Hajra Ahmad, Afeefa Khadija, Syeda Mahvish Zahra, Ashiq Hussain
Summary: This study discovered a high prevalence of stunting and wasting among children in Pakistan, with factors such as genetics, diet, and lack of information contributing to the problem. The study found that a significant number of mothers of stunted and wasted children were illiterate, and both the mothers and children had poor dietary patterns and quality due to lack of affordability. The findings conclude that these issues result in poor growth and development in children.
Review
Nutrition & Dietetics
Yoshihiko Kanno, Eiichiro Kanda, Akihiko Kato
Summary: Patients receiving dialysis therapy often face nutritional challenges, yet medical staff in Japan lack training and support in nutritional management. Recent studies suggest that under conditions of low nutrition, salt intake should not be restricted for frail or dialysis patients, and protein consumption should be targeted at 0.9 to 1.2 g/kg/day. The Nutritional Risk Index-Japanese Hemodialysis (NRI-JH) is recommended by the Japanese Society of Dialysis Therapy to screen for malnutrition in older patients.
Article
Nutrition & Dietetics
Yuri Machiba, Katsuhito Mori, Tetsuo Shoji, Yuki Nagata, Hideki Uedono, Shinya Nakatani, Akinobu Ochi, Akihiro Tsuda, Tomoaki Morioka, Hisako Yoshida, Yoshihiro Tsujimoto, Masanori Emoto
Summary: Nutritional disorder, evaluated by the Geriatric Nutritional Risk Index (GNRI), is associated with hospitalization and death in hemodialysis patients.
JOURNAL OF RENAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Hongquan Peng, Chiwa Aoieong, Tou Tou, Tsungyang Tsai, Jianxun Wu
Summary: Malnutrition is common among hemodialysis patients in Macao, but not influenced by diabetes. Serum creatinine, serum albumin, MAC, and pre-dialysis creatinine concentration are effective screening measures for nutritional status in maintenance dialysis patients.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Xiaoyu Chen, Peipei Han, Xiaoyan Zhu, Peiyu Song, Yinjiao Zhao, Hui Zhang, Chen Yu, Jianying Niu, Wei Ding, Junli Zhao, Liming Zhang, Hualin Qi, Suhua Zhang, Qi Guo
Summary: This study found that malnutrition, dynapenia, and sarcopenia are prevalent among patients with maintenance hemodialysis. The three nutritional screening tools (GNRI, MIS, and Cr index) are significantly associated with the risk of sarcopenia, with GNRI showing greater predictability compared to the other two tools.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Chou-Pin Kuo, Ming-Tsun Tsai, Kuo-Hua Lee, Yao-Ping Lin, Shao-Sung Huang, Chin-Chou Huang, Wei-Cheng Tseng, Der-Cherng Tarng
Summary: This study investigated the dose-response effects of physical activity on mortality and major cardiorenal events in chronic kidney disease patients. The results showed that physical activity of 7.5 to <15 MET-h/week was associated with lower risks of adverse cardiorenal outcomes.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Toxicology
Yen-An Chang, Der-Cherng Tarng, Chih-Yu Yang
Summary: This case report illustrates a patient with end-stage kidney disease who developed metformin-induced encephalopathy, presenting with characteristic brain imaging findings and neurological symptoms, which improved with intensive hemodialysis and discontinuation of the drug.
CLINICAL TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Meng-Rong Tsai, Chiu-Yang Lee, Chih-Yu Yang, Der-Cherng Tarng
Summary: This article reports the angiographic examination results of a chronic hemodialysis patient, in which a unique collateral venous branch sign resembling an eighth note was noted before the stenotic lesion. After percutaneous transluminal angioplasty, the eighth note sign attenuated significantly. The eighth note sign is not commonly seen and represents a specific vascular morphology.
Article
Cardiac & Cardiovascular Systems
Shuo-Ming Ou, Chieh-Ju Chao, Ming-Tsun Tsai, Kuo-Hua Lee, Wei-Cheng Tseng, Pin-Jie Bin, Yao-Ping Lin, Chien-Yi Hsu, Der-Cherng Tarng
Summary: Heart failure is prevalent in patients with chronic kidney disease (CKD), and its impact on renal function and long-term outcomes in different subtypes of heart failure remains uncertain. This study found that heart failure is associated with worse clinical outcomes, and patients with HFrEF have the highest risk.
Review
Cardiac & Cardiovascular Systems
Hao-Wei Lee, Chin-Chou Huang, Chih-Yu Yang, Hsin-Bang Leu, Po-Hsun Huang, Tao-Cheng Wu, Shing-Jong Lin, Jaw-Wen Chen
Summary: The study investigates the impact of renal function on cardiovascular outcomes in patients with acute decompensated heart failure (ADHF). Impaired renal function before discharge is found to be a significant risk factor for poor outcomes in ADHF patients.
CLINICAL CARDIOLOGY
(2023)
Article
Neurosciences
Yu-Jie Huang, Chia-Chi Hung, Pei-Chien Hsu, Po-Yi Lee, Yen-An Tsai, Yu-Chiao Hsin, Xie-Ting Lee, Chia-Cheng Chou, Mei-Lien Chen, Der-Cherng Tarng, Yi-Hsuan Lee
Summary: Chronic kidney disease (CKD) is associated with mental disorders caused by the accumulation of indoxyl-3-sulfate (I3S) in the brain. I3S induces oxidative stress and activates the aryl hydrocarbon receptor (AhR). This study showed that AhR plays a crucial role in CKD-induced brain disorders and disturbance of neuron-astrocyte interaction.
Article
Mathematical & Computational Biology
Shuo-Ming Ou, Ming-Tsun Tsai, Kuo-Hua Lee, Wei-Cheng Tseng, Chih-Yu Yang, Tz-Heng Chen, Pin-Jie Bin, Tzeng-Ji Chen, Yao-Ping Lin, Wayne Huey-Herng Sheu, Yuan-Chia Chu, Der-Cherng Tarng
Summary: This study aimed to develop predictive models for the risk of developing ESRD in newly diagnosed T2DM patients using machine learning. XGBoost was found to be the best model with high discriminative ability. These models can be used as risk assessment tools for clinical decision-making and early intervention strategies.
Review
Physiology
Ting-Wei Kao, Yi-Shiuan Liu, Chih-Yu Yang, Oscar Kuang-Sheng Lee
Summary: This review discusses the role of mechanical input in the differentiation of mesenchymal stem cells (MSCs) and the underlying mechanisms. Optimal cultural parameters, such as spatial boundary conditions and types of forces, can influence MSCs commitment. The concept of mechanical memory is introduced to understand how MSCs store information from previous culture environments. The cardiovascular system and immune system may share similar mechanisms of mechanosensing and mechanotransduction. The review summarizes the current evidence and highlights future perspectives in cardiovascular bioengineering and regenerative medicine.
CHINESE JOURNAL OF PHYSIOLOGY
(2023)
Article
Medical Laboratory Technology
Ming-Tsun Tsai, Ruey-Bing Yang, Shuo-Ming Ou, Wei-Cheng Tseng, Kuo-Hua Lee, Chih-Yu Yang, Fu -Pang Chang, Der-Cherng Tarng
Summary: Plasma galectin-9 levels are associated with varying stages of chronic kidney disease (CKD), and high levels are correlated with older age, decreased renal function, increased proteinuria, and greater interstitial fibrosis. In renal tissue, galectin-9 expression is positively correlated with plasma galectin-9 levels and is mainly expressed in macrophages.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Ming-Hsiu Chiang, Chih-Yu Yang, Yi-Jie Kuo, Chung-Yi Cheng, Shu-Wei Huang, Yu-Pin Chen
Summary: This study found a negative correlation between MCV and BMD at specific body locations in patients on dialysis. A decreased T-score was also found to be associated with macrocytosis.
MEDICINA-LITHUANIA
(2022)
Article
Urology & Nephrology
Heng-Cheng Tsai, Shuo-Ming Ou, Chih-Cheng Wu, Chin-Chou Huang, Jyh-Tong Hsieh, Po-Yu Tseng, Chiu-Yang Lee, Chih-Yu Yang, Der-Cherng Tarng
Summary: Plasma levels of pentraxin 3 (PTX3) are associated with the risk of arteriovenous fistula (AVF) functional patency loss and mortality in chronic hemodialysis patients.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)