Lentivirus pre-packed with Cas9 protein for safer gene editing

Delivering the Goods for Genome Engineering and Editing

(2015) Kristian Alsbjerg Skipper et al.   HUMAN GENE THERAPY

Expanding the Biologist’s Toolkit with CRISPR-Cas9

(2015) Samuel H. Sternberg et al.   MOLECULAR CELL

Application of CRISPR/Cas9 for biomedical discoveries

(2015) Sean M. Riordan et al.   Cell and Bioscience

Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine

(2014) Charles A Gersbach et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

CRISPR/Cas9 for genome editing: progress, implications and challenges

(2014) F. Zhang et al.   HUMAN MOLECULAR GENETICS

Applications of TALENs and CRISPR/Cas9 in Human Cells and Their Potentials for Gene Therapy

(2014) Jingwen Niu et al.   MOLECULAR BIOTECHNOLOGY

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

(2014) Y. Lin et al.   NUCLEIC ACIDS RESEARCH

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of HIV-1 from Latent Infection via Synergy of RUNX1 Inhibitor Ro5-3335 and SAHA

(2014) Zachary Klase et al.   PLoS Pathogens

Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases

(2014) Yujia Cai et al.   eLife

CCR5 Gene Editing of Resting CD4+ T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice

(2014) Guohua Yi et al.   Molecular Therapy-Nucleic Acids

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Cas9 as a versatile tool for engineering biology

(2013) Prashant Mali et al.   NATURE METHODS

DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors

(2013) Yujia Cai et al.   NUCLEIC ACIDS RESEARCH

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

(2013) Thomas J. Cradick et al.   NUCLEIC ACIDS RESEARCH

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

(2013) Xiying Qu et al.   NUCLEIC ACIDS RESEARCH

Newer Gene Editing Technologies toward HIV Gene Therapy

(2013) N. Manjunath et al.   Viruses-Basel

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

SnapShot: HIV-1 Proteins

(2008) Chad M. Swanson et al.   CELL

Substitution of the myristoylation signal of human immunodeficiency virus type 1 Pr55Gag with the phospholipase C- 1 pleckstrin homology domain results in infectious pseudovirion production

(2008) E. Urano et al.   JOURNAL OF GENERAL VIROLOGY