Article
Endocrinology & Metabolism
Xinru Deng, Chenhong Zhang, Pengxu Wang, Wei Wei, Xiaoyang Shi, Pingping Wang, Junpeng Yang, Limin Wang, Shasha Tang, Yuanyuan Fang, Yalei Liu, Yiqi Chen, Yun Zhang, Qian Yuan, Jing Shang, Quane Kan, Huihui Yang, Hua Man, Danyu Wang, Huijuan Yuan
Summary: This study aimed to explore the mechanism of empagliflozin on cardiovascular risk in patients with type 2 diabetes. The results showed that empagliflozin treatment improved cardiovascular risk factors and had significant effects on gut microbiota and plasma metabolites.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Limin Wang, Chenghong Liang, Xiaojian Song, Xiaoyan Jia, Xiudan Wang, Yun Zhang, Qinyuan Xie, Nan Zheng, Huijuan Yuan
Summary: This study aimed to assess alterations in the gut, oral, and ocular surface microbiota pre- and post-Cana treatment in patients with type 2 diabetes mellitus (T2DM). The results showed that there were significant changes in the gut, oral, and ocular surface microbiota after Cana treatment, which were related to changes in clinical parameters.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Zheng Zhou, Bao Sun, Dongsheng Yu, Chunsheng Zhu
Summary: Type 2 diabetes mellitus, a common metabolic disease, is associated with gut microbiota dysbiosis. Remodeling the gut microbiota may be a potential strategy for treating T2DM and its complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Arpita Arora, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Eduardo Sobarzo-Sanchez, Simona Bungau
Summary: Type 2 diabetes mellitus is a prevalent metabolic disorder characterized by high blood sugar, high blood lipids, and insulin resistance, with genetic mutations, obesity, lack of physical activity, and imbalances in gut microbiota being possible contributing factors. The balance of gut microbiota is crucial for maintaining human health.
Article
Endocrinology & Metabolism
Ge Yang, Jinlong Wei, Pinyi Liu, Qihe Zhang, Yuan Tian, Guowen Hou, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Type 2 diabetes is the fastest-growing metabolic disease in the world, with patients often experiencing disturbances in the gut microbiota and increased intestinal permeability. The gut microbiota, which plays a crucial role in metabolism and immune regulation, may serve as a potential therapeutic target for improving the outcomes of type 2 diabetes and related diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Medicine, Research & Experimental
Leilei Du, Qi Li, Huan Yi, Tingting Kuang, Yi Tang, Gang Fan
Summary: This review provides a timely and comprehensive summary of the microbial metabolites that are protective or causative for type 2 diabetes mellitus (T2DM), including amino acids-derived metabolites, short-chain fatty acids, trimethylamine N-oxide, and bile acids. The mechanisms by which these metabolites affect T2DM are elaborated, and frontier therapies targeting gut microbes and their metabolites to improve T2DM are critically discussed, including dietary intervention, fecal microbiota transplantation, probiotics, prebiotics or synbiotics intervention, and drugging microbial metabolism. This review offers novel insights for the development of targeted and personalized treatments for T2DM based on gut microbial metabolites, with the need for more high-quality clinical trials.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Food Science & Technology
Haoran Jiang, Miaomiao Cai, Boyuan Shen, Qiong Wang, Tongcun Zhang, Xiang Zhou
Summary: The number of people with type 2 diabetes mellitus (T2DM) has increased sharply, largely due to factors such as genetic predisposition and unhealthy diet and lifestyle. The consumption of probiotics and prebiotics to gain health benefits has gained acceptance in recent years, with accumulating studies confirming their critical roles in alleviating T2DM symptoms. Synbiotics, a combination of prebiotics and probiotics, show a synergistic effect on T2DM by modulating the gastrointestinal microenvironment.
Article
Nutrition & Dietetics
Yuriko Kondo, Yoshitaka Hashimoto, Masahide Hamaguchi, Ayumi Kaji, Ryosuke Sakai, Ryo Inoue, Saori Kashiwagi, Katsura Mizushima, Kazuhiko Uchiyama, Tomohisa Takagi, Yuji Naito, Michiaki Fukui
Summary: This study examines the association between smoking and gut microbiota, taking into account the impact of smoking on dietary intake. The results show that smoking is associated with both dietary intake and the composition of the gut microbiota.
Review
Endocrinology & Metabolism
Jiaqiang Wu, Kangping Yang, Hancheng Fan, Meilin Wei, Qin Xiong
Summary: This review summarizes the molecular links between gut microbiota-derived metabolites and the pathogenesis of type 2 diabetes mellitus (T2DM). It also reviews potential therapies for T2DM involving modulating the gut microbiota and its metabolites through probiotics, prebiotics, fecal microbiota transplantation, and other methods. Clinical trials investigating the role of gut microbiota and its metabolites are critically discussed. The review highlights the potential therapeutic strategy of targeting the gut microbiota and its metabolites for the prevention and treatment of T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Gastroenterology & Hepatology
A. L. Cunningham, J. W. Stephens, D. A. Harris
Summary: The evidence supports the impact of gut microbiota on human metabolism, especially in relation to altered glucose homeostasis and the development of type 2 diabetes mellitus (T2DM) and associated complications. Understanding the causal association between gut microbiota and metabolic risk could help identify susceptible individuals for early targeted intervention.
Article
Nutrition & Dietetics
Karolina Drozdz, Katarzyna Nabrdalik, Weronika Hajzler, Hanna Kwiendacz, Janusz Gumprecht, Gregory Y. H. Lip
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common condition associated with type 2 diabetes (T2DM) and cardiovascular disease (CVD). The new term metabolic-associated fatty liver disease (MAFLD) highlights the bidirectional relationships between NAFLD, T2DM, and CVD. Lifestyle changes and targeting the gut microbiota may be important for NAFLD treatment.
Review
Medicine, Research & Experimental
Duygu Agagunduz, Mehmet Arif Icer, Ozge Yesildemir, Tevfik Kocak, Emine Kocyigit, Raffaele Capasso
Summary: Type 2 diabetes mellitus (T2DM) is a systemic inflammatory disease characterized by dysfunctional pancreatic beta-cells and insulin resistance, and it is influenced by genetic, metabolic, lifestyle, and sociodemographic factors. The disease is also affected by dietary lipids, lipid metabolism, and gut microbiota. Lipidomics analysis has shown potential in understanding the pathogenesis and progression of T2DM. Understanding the interactions between dietary lipids, lipidomics, and gut microbiota can lead to new strategies for the prevention and treatment of T2DM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andrea Piccioni, Federico Rosa, Sergio Mannucci, Federica Manca, Giuseppe Merra, Sabrina Chiloiro, Marcello Candelli, Marcello Covino, Antonio Gasbarrini, Francesco Franceschi
Summary: This article focuses on the relationship between alterations in the gut microbiome and the onset of type 1 diabetes mellitus and LADA, based on the latest evidence. It discusses the crucial role of the gut microbiota in the pathogenesis of these disorders and explores how modulating the gut microbiota through probiotics, prebiotics, and fecal microbiota transplantation can lead to potential therapeutic strategies.
Article
Microbiology
Yuan Ren, Lilan Hao, Juntao Liu, Pei Wang, Qiuxia Ding, Chen Chen, Yingna Song
Summary: In this study, the changes in gut microbiota composition in pregnant women with and without pregestational type 2 diabetes mellitus (PGDM) were investigated. The results showed that the gut microbiota in the PGDM group decreased as the pregnancies progressed, and certain bacteria taxa were enriched in the PGDM group. Moreover, the gut microbiota in the PGDM group was correlated with blood glucose levels during pregnancy. This study is important for understanding the relationship between PGDM and gut microbiota.
Article
Nutrition & Dietetics
Yuriko Kondo, Yoshitaka Hashimoto, Masahide Hamaguchi, Shinto Ando, Ayumi Kaji, Ryosuke Sakai, Ryo Inoue, Saori Kashiwagi, Katsura Mizushima, Kazuhiko Uchiyama, Tomohisa Takagi, Yuji Naito, Michiaki Fukui
Summary: This study revealed that the characteristic gut microbiota of Japanese patients with type 2 diabetes may be associated with dietary habits, the use of diabetes medications, and the intake of fermented foods. The red group had higher percentages of the Bifidobacterium and Lactobacillus genera, and lower percentages of the Blautia and Phascolarctobacterium genera in their gut microbiota, suggesting potential implications for T2DM management.
Letter
Gastroenterology & Hepatology
Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Pei-Wen Wu, Yi-Wen Lai, Yu-Ting Chin, Sharon Tsai, Tun-Min Yang, Wei-Ting Lin, Chun-Ying Lee, Wei-Chung Tsai, Hsiao-Ling Huang, David W. Seal, Tsai-Hui Duh, Chien-Hung Lee
Summary: This study found that the clustering structure of MetS remains stable during adolescence. Abdominal obesity and low high-density lipoprotein cholesterol are two MetS components that persist throughout adolescence and are important targets for intervention to reduce the risk of future cardiometabolic disorders.
Article
Environmental Sciences
Chen-Cheng Yang, Chia-Yen Dai, Kuei-Hau Luo, Kuo-Wei Lee, Cheng-Hang Wu, Chih-Hsing Hung, Hung-Yi Chuang, Chao-Hung Kuo
Summary: This study found a negative association between lead exposure and high-density lipoprotein cholesterol (HDL-C) levels. Two specific SNPs were significantly associated with HDL-C in lead-exposed workers, and an interaction between one of the SNPs (rs150813626) and lead exposure had a positive influence on HDL-C. The TWIST gene may play a role in lead deposition in bones and calcium metabolism.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Shih-Jie Jhuo, Tsung-Hsien Lin, Yi-Hsiung Lin, Wei-Chung Tsai, I-Hsin Liu, Bin-Nan Wu, Kun-Tai Lee, Wen-Ter Lai
Summary: This study demonstrated that treatment of type 2 diabetes mellitus patients with SGLT2 inhibitors could significantly reduce the incidence of total cardiac arrhythmia and atrial fibrillation, as well as decrease the risk of stroke, heart failure, and myocardial infarction. Additional investigations are needed to further confirm these findings.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Yi-Shan Tsai, Ching- Huang, Pei-Chien Tsai, Ming-Lun Yeh, Chung-Feng Huang, Meng-Hsuan Hsieh, Ta-Wei Liu, Yi-Hung Lin, Po-Cheng Liang, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Wan-Long Chuang, Chia-Yen Dai, Ming-Lung Yu
Summary: This longitudinal follow-up study aimed to assess whether Let-7 family members can predict hepatocellular carcinoma (HCC) risk in patients with chronic hepatitis C (CHC). The results showed that Let-7i can serve as an effective surrogate biomarker for predicting HCC development in patients with CHC. Thus, circulating Let-7i can be used for early surveillance of CHC in patients at risk of HCC after antiviral treatment.
Article
Health Care Sciences & Services
Che-Sheng Pai, Cheng-Yuan Wang, Wei-Wen Hung, Wei-Chun Hung, Hui-Ju Tsai, Chen-Chia Chang, Shang-Jyh Hwang, Chia-Yen Dai, Wen-Yu Ho, Yi-Chun Tsai
Summary: This study revealed that in Asian T2D patients, the decreased abundance of fecal A. muciniphila exacerbated the severity of insulin resistance, especially in those with lean mass. The negative correlation between A. muciniphila and insulin resistance was found in T2D patients with high lean tissue, and this relationship was independent of obesity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Wei-Chung Tsai, Ming-Lung Yu, Chia-Yen Dai
JOURNAL OF HEPATOLOGY
(2022)
Letter
Infectious Diseases
Chia-Yen Dai, Chung-Feng Huang, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu
JOURNAL OF INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Chia-Yen Dai, Tzu-Jung Fang, Wei-Wen Hung, Hui-Ju Tsai, Yi-Chun Tsai
Summary: This study evaluates the determinants of liver fibrosis in T2D patients with NAFLD. The results indicate that aging, obesity, sulfonylurea usage, and high levels of AST increase the risk of liver fibrosis in these patients.
Article
Virology
Po-Yao Hsu, Po-Cheng Liang, Ching- Huang, Meng-Hsuan Hsieh, Yi-Shan Tsai, Tzu-Chun Lin, Ming-Lun Yeh, Chung-Feng Huang, Chih-Wen Wang, Tyng-Yuan Jang, Yi-Hung Lin, Zu-Yau Lin, Wan-Long Chuang, Chia-Yen Dai
Summary: High accessibility to healthcare and increased awareness of HCC surveillance after SVR allow early detection of operable HCC in Taiwan. Achieving SVR improves liver function but does not significantly affect surgical outcomes for HCC patients.
Letter
Public, Environmental & Occupational Health
Chia-Yen Dai, Ming-Lung Yu, Hung-Yi Chuang, Chi-Kung Ho, Chao-Ling Wang
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Immunology
Te-Wei Cheng, Jeng-Fu Yang, Yi-Yu Chen, Kuan-Ta Wu, Meng-Szu Lee, Hsiang-Ju Kuo, Tzu-Chun Lin, Chao-Ling Wang, Meng-Hsuan Hsieh, Chia-Yi Lin, Batbold Batsaikhan, Chi-Kung Ho, Chia-Yen Dai
Summary: The prevalence of hepatitis B virus (HBV) infection among college-aged individuals in Taiwan after mass vaccination remains uncertain. A study was conducted to investigate the prevalence of hepatitis B markers in different birth cohorts. The results showed a decreasing trend in HBsAg and anti-HBs seropositive rates among college students in the Kaohsiung area. The status of HBsAg was found to be a predictive factor of abnormal ALT levels, and a time effect on anti-HBs seropositivity for DNA recombinant vaccine was observed.
Article
Nutrition & Dietetics
Hui-Ju Tsai, Wei-Chun Hung, Wei-Wen Hung, Yen-Jung Lee, Yo-Chia Chen, Chun-Ying Lee, Yi-Chun Tsai, Chia-Yen Dai
Summary: This study aimed to explore the association between short-chain fatty acids (SCFAs) and the severity of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2D) patients. The results showed that the circulating levels of isobutyrate and methylbutyrate were negatively correlated with NAFLD severity. This suggests that SCFAs may be related to the severity of NAFLD in T2D patients.
Article
Oncology
Zu-Yau Lin, Ming-Lun Yeh, Po-Cheng Liang, Po-Yao Hsu, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Ming-Lung Yu, Wan-Long Chuang
Summary: This study aimed to investigate the dose-dependent anti-cancer effect of lenvatinib on hepatocellular carcinoma (HCC) cells and the potential benefit of combined colchicine therapy. The results showed that lenvatinib did not exhibit a dose-dependent anti-cancer effect on HCC, but combined treatment with colchicine and lenvatinib promoted the overall anti-cancer effects on HCC.