Article
Biochemistry & Molecular Biology
Stephanie M. Zimmerman, Robin Fropf, Bridget R. Kulasekara, Maddy Griswold, Oliver Appelbe, Arya Bahrami, Rich Boykin, Derek L. Buhr, Kit Fuhrman, Margaret L. Hoang, Quoc Huynh, Lesley Isgur, Andrew Klock, Alecksandr Kutchma, Alexa E. Lasley, Yan Liang, Jill McKay-Fleisch, Jeffrey S. Nelson, Karen Nguyen, Erin Piazza, Aric Rininger, Daniel R. Zollinger, Michael Rhodes, Joseph M. Beechem
Summary: Emerging spatial profiling technology allows high-plex molecular profiling in biological tissues while preserving the spatial and morphological context of gene expression. By expanding the chemistry for the Digital Spatial Profiling platform, researchers have successfully quantified whole transcriptomes in human and mouse tissues, enabling applications in cancer research, molecular pathology, and developmental biology.
Article
Multidisciplinary Sciences
Balazs Gocz, Eva Rumpler, Miklos Sarvari, Katalin Skrapits, Szabolcs Takacs, Imre Farkas, Veronika Csillag, Sarolta H. Trinh, Zsuzsanna Bardoczi, Yvette Ruska, Norbert Solymosi, Szilard Poliska, Zsuzsanna Szoke, Lucia Bartoloni, Yassine Zouaghi, Andrea Messina, Nelly Pitteloud, Ross C. Anderson, Robert P. Millar, Richard Quinton, Stephen M. Manchishi, William H. Colledge, Erik Hrabovszky
Summary: This study provides a comprehensive characterization of the estrogen-dependent kisspeptin neuron transcriptome and sheds light on the molecular mechanisms of ovary-brain communication, which is important for genetic research on human fertility disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Yi-Rong Jiang, Le Zhu, Lan-Rui Cao, Qiong Wu, Jian-Bo Chen, Yu Wang, Jie Wu, Tian-Yu Zhang, Zhao-Lun Wang, Zhi-Ying Guan, Qin-Qin Xu, Qian-Xi Fan, Shao-Wen Shi, Hui-Feng Wang, Jian-Zhan Pan, Xu-Dong Fu, Yongcheng Wang, Qun Fang
Summary: A new single-cell analysis platform, capable of simultaneously analyzing the transcriptome and proteome, provides an important resource for understanding the relationship between transcription and translation in cells. By applying this platform to mouse oocytes, we investigated the correlation between RNA and protein, as well as the meiosis regulatory network, and identified specific oocyte maturational signatures.
Article
Biotechnology & Applied Microbiology
Juan-Carlos A. Padilla, Seda Barutcu, Ludovic Malet, Gabrielle Deschamps-Francoeur, Virginie Calderon, Eunjeong Kwon, Eric Lecuyer
Summary: This study provides novel insights into the compositional diversity of poly-A transcript isoforms enriched within EVs and highlights the potential usefulness of nanopore sequencing in interrogating secreted RNA transcriptomes.
Article
Immunology
Zhihui Yin, Hongtao Nie, Kunyin Jiang, Xiwu Yan
Summary: The clam Ruditapes philippinarum is an important species in the marine aquaculture industry in China, but its cultivation has been negatively impacted by bacterial pathogens. In this study, transcriptome libraries of R. philippinarum with different resistance levels against Vibrio anguillarum were constructed and analyzed. Several immune factors responding to V. anguillarum infection were identified, providing insights into the immune response of R. philippinarum. The findings contribute to the understanding of resistant genes and key pathways related to Vibrio challenge in this species.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sarah M. Kedziora, Benedikt Obermayer, Meryam Sugulle, Florian Herse, Kristin Kraeker, Nadine Haase, Immaculate M. Langmia, Dominik N. Muller, Anne Cathrine Staff, Dieter Beule, Ralf Dechend
Summary: The placenta is a temporary organ with a unique structure and function to ensure healthy fetal development. Placental dysfunction caused by diabetes affects placental metabolism, inflammation, and weight, but the main driver of gene expression differences in the placenta is fetal sex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Pierre Moffatt, Iris Boraschi-Diaz, Ghalib Bardai, Frank Rauch
Summary: The study revealed that two severe OI mouse models share abnormalities in the expression of genes related to extracellular matrix proteins, lipid and energy metabolism, and structural proteins of type I muscle fibers. These muscle disturbances could be viewed as a mild form of muscle dystrophy caused by collagen type I mutations.
Article
Agriculture, Dairy & Animal Science
Yingjie Wu, Lihua Zhao, Yinghe Qin
Summary: This study aimed to investigate the relationship between the severity of clinical signs and pathological observations in rabbit mastitis and analyze the differentially expressed genes (DEGs). The results showed that rabbits with mild and severe mastitis had higher rectal temperatures compared to the control group. The somatic cell count in milk was significantly higher in severe mastitis, while the number of heterophils in histological sections was significantly higher in mild mastitis. RNA-sequencing identified 1,096 DEGs between the control and mastitis mammary glands, with up-regulated genes enriched in response to stimulus, signal transduction, and cell communication, and downregulated genes mainly enriched in metabolic processes and pathways.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Pierre Moffatt, Iris Boraschi-Diaz, Juliana Marulanda, Ghalib Bardai, Frank Rauch
Summary: Comparing the transcriptome of calvaria bone tissue in different types of OI mouse models revealed shared dysregulated genes that may play an important role in the pathophysiology of the disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Miao Yuqing, Gao Shang, Gao Qing, Wang Jiyang, Li Ruihao, Chen Zuoguan, Diao Yongpeng, Wu Zhiyuan, Li Yongjun
Summary: This study used bulk RNA sequencing to explore the alterations of mRNA in Takayasu arteritis (TA) and found the critical roles of interleukins in its pathogenesis. Smooth muscle cells may also participate in the vessel wall reconstruction at the late stage of TA.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Erteng Jia, Yuqi Sheng, Huajuan Shi, Ying Wang, Ying Zhou, Zhiyu Liu, Ting Qi, Min Pan, Yunfei Bai, Xiangwei Zhao, Qinyu Ge
Summary: This study analyzed the gene expression features of single cells in different spatial locations of the mouse hippocampus and explored the effects of gene expression regulation on learning and memory mechanisms. The expressions of Sv2b, Neurod6, Grp, and Stk32b genes varied significantly in single cells at different locations in the hippocampus, and marker genes for CA1, CA3, and DG subregions were identified. The up-regulated genes were mainly involved in neuron to neuron synapse, vesicle-mediated transport in synapse, calcium signaling pathway, and neurodegenerative disease pathways, affecting learning and memory function. These findings are crucial for understanding the pathogenesis of Parkinson's disease and developing precise treatment plans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chih-Chieh Chen, Yung-Che Chou, Chia-Yi Hsu, Eing-Mei Tsai, Tze-Kiong Er
Summary: In this study, RNA sequencing analysis was used to identify a potential pathogenic gene of endometriosis. The differentially expressed genes were found to be enriched in several signaling pathways, providing new insights into the underlying mechanisms of endometriosis.
Article
Endocrinology & Metabolism
Xiao Wang, Fanyi Qiu, Junjie Yu, Meiyang Zhou, Anjian Zuo, Xiaojiang Xu, Xiao-Yang Sun, Zhengpin Wang
Summary: Using physical microdissection, researchers isolated the initial segment (IS) and proximal caput (P-caput) of the mouse epididymis and identified region-specific genes through RNA sequencing. These genes were found to be associated with sperm transport, maturation, and male fertility, making them potential targets for male contraception and providing insights into the epididymal microenvironment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Plant Sciences
Xiaoying Pan, Junbiao Chen, Aiguo Yang, Qinghua Yuan, Weicai Zhao, Tingyu Xu, Bowen Chen, Min Ren, Ruimei Geng, Zhaohui Zong, Zhuwen Ma, Zhenrui Huang, Zhenchen Zhang
Summary: This study characterized the physiological differences and compared the defense-related transcriptomes of two tobacco varieties under R. solanacearum infection, revealing genotype-specific regulation and expression differences in defense-related genes. The results provide insight into the molecular mechanisms underlying plant-pathogen interaction and resistance to R. solanacearum in tobacco.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Oncology
Wanru Duan, Boyan Zhang, Xinqiang Li, Wei Chen, Shanhang Jia, Zong Xin, Qiang Jian, Fengzeng Jian, Dean Chou, Zan Chen
Summary: This study used single-cell RNA sequencing to explore the transcriptomic landscape of chordomas, revealing the heterogeneity of chordomas and identifying the characteristics of epithelial-like extracellular matrix, stem cells, and immunosuppressive activity. The enhancement of the TGF-beta signaling pathway was found to be the main mechanism for tumor progression, invasion, and immunosuppression in chordomas.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Genetics & Heredity
Yue Xie, Sen Wang, Shuangyang Wu, Shenghan Gao, Qingshu Meng, Chengdong Wang, Jingchao Lan, Li Luo, Xuan Zhou, Jing Xu, Xiaobin Gu, Ran He, Zijiang Yang, Xuerong Peng, Songnian Hu, Guangyou Yang
Summary: This study reveals the host adaptation of Baylisascaris schroederi to the giant panda and provides insights into the evolutionary trajectory of host-shift events in ascaridoid parasite lineages. The specific adaptations of B. schroederi to survive in the gut of giant pandas, such as increasing cuticle thickness and efficient utilization of host nutrients, are characterized. The findings of this study will aid in the development of prevention and treatment measures to protect giant panda populations from roundworm parasitism.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Fisheries
Guo Guangxin, Kexin Li, Qianhui Zhu, Chunyan Zhao, Chao Li, Zilong He, Songnian Hu, Yichao Ren
Summary: Plant extract oregano oil and probiotics can improve growth performance and disease resistance in cultured fish by modulating the gut microbiota and immune-related gene expression. The use of oregano oil or Bacillus coagulans as dietary additives shows potential health benefits for fish, enhancing growth and immunity through microbiota modulation.
Article
Medicine, General & Internal
Yuting Wang, SongNian Hu, XinYu Tan, Qingqing Sang, Peng Shi, Chun Wang, Daoqian Sang
Summary: This study aimed to identify possible pathogenic gene mutations in a family with tuberous sclerosis complexes (TSCs). Through clinical evaluations and genetic sequencing, a splicing site mutation was found in the 9th intron region of TSC1. This suggests that mutations in intron regions may contribute to the development of TSC.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jianing Geng, Sainan Luo, Hui-Ru Shieh, Hsing-Yi Wang, Songnian Hu, Yi-Ywan M. Chen
Summary: This study identified CodY orthologues and corresponding regulons in Gram-negative Synergistetes, and confirmed a novel palindromic sequence with AT-rich arms in the promoters of putative codY-containing operons. The function of this consensus sequence was tested using a recombinant CodY protein in Synergistetes, showing similarities to Firmicutes CodY.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Yongqin Liu, Mukan Ji, Tao Yu, Julian Zaugg, Alexandre M. Anesio, Zhihao Zhang, Songnian Hu, Philip Hugenholtz, Keshao Liu, Pengfei Liu, Yuying Chen, Yingfeng Luo, Tandong Yao
Summary: The study presents a comprehensive glacier microbial genome and gene catalog from Tibetan glaciers, which includes genomes and metagenome-assembled genomes representing 968 candidate species from 30 phyla. The catalog also contains over 25 million non-redundant protein-encoding genes and has demonstrated its utility in exploring secondary metabolite biosynthetic potentials, identifying virulence factors, and comparing global glacier metagenomes.
NATURE BIOTECHNOLOGY
(2022)
Article
Genetics & Heredity
Tao Yang, Rong Liu, Yingfeng Luo, Songnian Hu, Dong Wang, Chenyu Wang, Manish K. Pandey, Song Ge, Quanle Xu, Nana Li, Guan Li, Yuning Huang, Rachit K. Saxena, Yishan Ji, Mengwei Li, Xin Yan, Yuhua He, Yujiao Liu, Xuejun Wang, Chao Xiang, Rajeev K. Varshney, Hanfeng Ding, Shenghan Gao, Xuxiao Zong
Summary: In this study, a de novo assembly and annotation of a pea cultivar ZW6 was reported, which showed significant improvements in contig length and sequence quality compared to existing ones. The genome diversity analysis revealed that Pisum abyssinicum is a distinct species from P. fulvum and P. sativum within Pisum. Quantitative trait locus analyses identified Mendel's genes related to stem length and seed shape, as well as candidate genes for pod form. The construction of a pan-genome of 116 pea accessions revealed distinct functional enrichment in preferred genes of P. abyssinicum and P. fulvum. These findings provide insights into pea genome evolution and domestication, and offer valuable genomic resources for pea improvement.
Article
Immunology
Zhaoqi Zhang, Elhusseny A. Bossila, Ling Li, Songnian Hu, Yong Zhao
Summary: This study used RNA-seq data to analyze transcriptome profiles and cell metabolism during monocyte development, revealing important genes and pathways involved in this process. The findings provide valuable insights into the dynamics of monocyte development in bone marrow.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Na Liu, Danping Liu, Kexin Li, Songnian Hu, Zilong He
Summary: This study utilized Staphylococcus aureus as a model organism to investigate the driving factors influencing bacterial pan-genome composition. The research found that the sequence type plays a significant role in the dynamic distribution of bacterial genes. A new classification method and marker gene combination were proposed, providing insights for the classification of Staphylococcus aureus.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Si Yu, Xiaomeng Ge, Hui Xu, Bei Tan, Bowen Tian, Yujie Shi, Yimin Dai, Yue Li, Songnian Hu, Jiaming Qian
Summary: This study aimed to assess the gut microbiome and mycobiome in IBD patients with CDI. The results showed that IBD patients with CDI had decreased bacterial alpha diversity and significant differences in bacterial and fungal beta diversity compared to healthy individuals and IBD patients without CDI. Specific bacterial and fungal taxa were overrepresented in IBD patients with CDI. These findings provide insights into the pathological process and potential strategies for diagnosis and treatment in this subset of patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Xin Ma, Kexin Li, Fang Li, Jing Su, Weiwei Meng, Yanming Sun, Hui Sun, Jiazheng Sun, Yonghe Yuan, Yujia Lin, Songnian Hu, Xuefang Xu, Zilong He
Summary: Tracing foodborne botulism events quickly and accurately is crucial. This study used whole-genome sequencing and established universal core gene markers to successfully trace the relationship between clinical and food C. botulinum isolates, and identified three outbreaks.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Yahui Guo, Xiaojie Yu, Jixiao Wang, De Hua, Yuanhai You, Qingbo Wu, Qinglong Ji, Jianzhong Zhang, Liefei Li, Yuan Hu, Zhonghui Wu, Xiaoyue Wei, Lianqun Jin, Fanliang Meng, Yuhua Yang, Xiaofeng Hu, Lijin Long, Songnian Hu, Heyuan Qi, Juncai Ma, Wenwen Bei, Xiaomei Yan, Haibin Wang, Zilong He
Summary: ST7 Staphylococcus aureus, which is highly prevalent in humans, pigs, and food in China, has rarely been reported to cause staphylococcal food poisoning (SFP). However, a recent outbreak of SFP caused by ST7 S. aureus strains occurred in two kindergartens in Hainan Province, China. Whole-genome sequencing analysis revealed the genetic characteristics and phylogenetic relationships of these SFP strains and provided insights into the potential risk of this emergent ST7 clone for SFP.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Zhi-Lin Ling, Bin Cao, Song-Nian Hu, Jia-Ning Geng, Fei Liu, Dong-Mei Liu, Rui-Lin Zhao
Summary: Agaricus sinodeliciosus, a rare wild edible mushroom from northwest China, shows unique genome changes and activates specific genes for saline-alkali tolerance. Transcriptomic analyses reveal the importance of carbon and nitrogen utilization, cell stability, and fruit body formation under mildly alkaline conditions. This research enhances our understanding of the genomic evolution and mechanisms of A. sinodeliciosus in tolerance to saline-alkali environments.
MICROBIAL GENOMICS
(2023)
Article
Microbiology
Qianhui Zhu, Shenghan Gao, Binghan Xiao, Zilong He, Songnian Hu
Summary: In this study, a novel plasmid prediction tool called Plasmer was proposed, which combines the advantages of shared k-mers and genomic features. Plasmer can predict plasmids in multiple species and has achieved high accuracy on contigs above 500 bp. It outperforms existing methods in terms of performance and has balanced sensitivity and specificity.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Chang Shu, Qinglan Sun, Guomei Fan, Kesheng Peng, Zhengfei Yu, Yingfeng Luo, Shenghan Gao, Juncai Ma, Tao Deng, Songnian Hu, Linhuan Wu
Summary: The VarEPS-Influ database is a risk assessment system for influenza virus variations that comprehensively evaluates various aspects of mutations, including physical and chemical properties, structural features, receptor affinity, antibody binding capacity, etc., and considers factors such as time and spatial distribution and host species distribution. It accurately evaluates and predicts the risk of influenza virus variations.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
L. Zeng, X. Tan, S. Hu, Y. Luo
Summary: This study investigated the complexity and characteristics of the rice nuclear transcriptome. The expression of transposable element-related genes was found to be higher in the nucleus compared to protoplasts. Additionally, nuclear-enriched long non-protein coding RNAs were found to be co-expressed with nuclear-located RNA binding proteins. These findings provide valuable insights into the functional characterization of nuclear-expressed transposable element-related genes and lncRNAs.
JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
