Review
Pharmacology & Pharmacy
Amir Barzegar Behrooz, Zahra Talaie, Amir Syahir
Summary: Aggressive glioblastoma (GBM) is a primary brain tumor with no known treatment. However, drug delivery based on nanotechnology holds the potential to address the challenges of treating GBM. Combination therapies have shown better efficacy in GBM treatment, and nanotechnology can enhance the effectiveness of combination treatments.
Article
Chemistry, Multidisciplinary
Ceren Kimna, Theresa Monika Lutz, Hongji Yan, Jian Song, Thomas Crouzier, Oliver Lieleg
Summary: A nanoparticle-based drug delivery system has been designed to release therapeutic agents into disease cells based on specific DNA sequences, showing potential for targeted treatments of specific diseases.
Article
Biophysics
Sylwia Michlewska, Zuzana Garaiova, Veronika Subjakova, Marcin Holota, Ma lgorzata Kubczak, Marika Grodzicka, Elzbieta Okla, Nikolaos Naziris, Lucja Balcerzak, Paula Ortega, Francisco Javier de la Mata, Tibor Hianik, Iveta Waczulikova, Maria Bryszewska, Maksim Ionov
Summary: In this study, we combined dendritic and liposomal carriers and analyzed the biochemical and biophysical properties of these formulations. Lipid-coated dendritic carriers showed significantly improved transfection profiles and lower toxicity to erythrocyte membranes compared to noncomplexed components. The nanometric size, low polydispersity index, and reduced positive zeta potential of these complexes make them attractive for future drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Engineering, Biomedical
Wenzhao Liu, Zhanjun Ma, Yonggang Wang, Jingjing Yang
Summary: Low back pain is a common disease that causes a significant burden on individuals and society. Inter-vertebral disc degeneration is considered to be the main cause of low back pain, but current treatments cannot reverse the degeneration. With advancements in nanotechnology and regenerative medicine, nano-drug delivery systems offer promising solutions for the treatment of inter-vertebral disc degeneration.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Mehrab Pourmadadi, Shima Ostovar, Gustavo Ruiz-Pulido, Dilawar Hassan, Maryam Souri, Amanda-Lee Ezra Manicum, Razieh Behzadmehr, Sonia Fathi-karkan, Abbas Rahdar, Dora I. Medina, Sadanand Pandey
Summary: Cancer is a global disease that affects millions of people, and in 2023, there are projected to be 1,958,310 new cancer cases and 609,820 cancer fatalities in the United States. Epirubicin is a potential anticancer chemotherapy agent that has shown efficacy against various malignancies. Nanotechnology has been used to develop novel drug delivery systems to enhance the therapeutic efficacy of EPI and overcome its limitations.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Nanoscience & Nanotechnology
Hazem Choukaife, Salma Seyam, Batoul Alallam, Abd Almonem Doolaanea, Mulham Alfatama
Summary: This article summarizes the pathology and therapy of colorectal cancer (CRC), as well as the challenges faced by oral drug delivery. It emphasizes the role of nanotechnology in oral drug targeted delivery systems and the significance of chitosan and its derivatives.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Marcela Tavares Luiz, Leonardo Delello di Filippo, Jessyca Aparecida Paes Dutra, Juliana Santos Rosa Viegas, Amanda Leticia Polli Silvestre, Caroline Anselmi, Jonatas Lobato Duarte, Giovana Maria Fioramonti Calixto, Marlus Chorilli
Summary: Dental caries is a common oral disease caused by bacteria that produce acid, leading to enamel demineralization and cavity formation. Effective drug delivery systems, including mucoadhesive systems, liquid crystalline systems, nanoparticles, and inorganic nanoparticles, have shown great potential in preventing and treating dental caries. This review focuses on these main drug delivery systems.
Review
Chemistry, Medicinal
He Ma, Zhenxiang Pan, Bingjie Lai, Chunfang Zan, He Liu
Summary: From a clinical perspective, local anesthetics have widespread application in various medical procedures. However, traditional local anesthetic agents have limitations such as neurotoxicity and short duration of action. Nanotechnology-based drug delivery systems have emerged as a promising solution to enhance drug release and prolong the effects of local anesthetics with reduced systemic toxicity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Chemistry, Multidisciplinary
Ujala Gupta, Brojendra Nath Saren, Kedar Khaparkhuntikar, Jitender Madan, Pankaj Kumar Singh
Summary: Breast cancer is the most common malignancy in women worldwide, and current therapies have limited effectiveness for advanced and metastatic breast cancers. Nanotechnology, particularly lipid-based nanoplatforms, has emerged as a promising approach for breast cancer treatment due to their controlled drug release, reduced toxicity, and improved drug encapsulation efficiency. This review summarizes the applications of lipid-engineered nanotechnological tools in breast cancer treatment and discusses the use of various therapeutic agents, including chemotherapeutics, phytomedicine, genes, peptides, photosensitizers, and immunogenic agents. It provides detailed information on the physicochemical properties of lipidic nanocarriers, in vitro and in vivo studies, and clinical trials. Overall, the review highlights the potential of lipidic nanoplatforms as a promising strategy for cancer nanotherapeutics.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Ding Wang, Qi Jiang, Zhefan Dong, Tingting Meng, Fuqiang Hu, Jianwei Wang, Hong Yuan
Summary: Oral administration is the preferred route of drug delivery in clinical practice. Nanotechnology offers a promising approach for overcoming barriers to drug absorption in the gastrointestinal tract and improving the oral bioavailability of drugs through the use of nanocarriers.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Biotechnology & Applied Microbiology
Priya Patel, Rohit Pal, Krishna Butani, Sudarshan Singh, Bhupendra G. Prajapati
Summary: Nanotechnology has significant potential in the field of cosmetics, offering improved efficacy and addressing issues with traditional cosmetics. The use of nanocarriers such as vesicles and solid lipid nanoparticles enhances product effectiveness, particularly in treating common skin diseases.
Review
Nanoscience & Nanotechnology
Wenli Zhang, Enshi Hu, Yajie Wang, Si Miao, Yanyan Liu, Yumin Hu, Ji Liu, Bohui Xu, Daquan Chen, Yan Shen
Summary: Currently, bacteria have developed significant resistance to most antibiotics, highlighting the need to develop targeted antibiotic delivery systems using nanotechnology to increase drug concentration at infection sites and reduce side effects in normal tissues.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Medicinal
Sonia Fathi-karkan, Rabia Arshad, Abbas Rahdar, Aghdas Ramezani, Razieh Behzadmehr, Suresh Ghotekar, Sadanand Pandey
Summary: This article summarizes significant progress in the development of Etoposide (ETO) nanomedicine for the treatment of cancer, focusing on the various organic and inorganic nanostructures used to load or affix ETOs. It evaluates the structural properties and performance of these nanostructures, as well as the importance of co-delivery with other medications or agents to combat drug resistance. The article concludes with a discussion of the challenges and potential avenues for clinical translation of ETO nanomedicine.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Camilla Molteni, Concettina La Motta, Fabio Valoppi
Summary: This review summarizes the progress made in improving the intake efficiency of carotenoids through nanostructured delivery systems, and discusses the formulation and functional efficiency of available nanocarriers.
Review
Pharmacology & Pharmacy
Maria Bernadete Riemma Pierre
Summary: Photodynamic Therapy (PDT) is an effective treatment for skin disorders, utilizing photosensitizers to destroy tumors after activation by light. Nanotechnology-based drug delivery systems show promise in enhancing the efficiency of PDT for cancer treatment.
CURRENT DRUG TARGETS
(2021)
Review
Dermatology
Lidia K. Al-Halaseh, Sujood Al-Adaileh, Alsafa Mbaideen, Maha N. Abu Hajleh, Ali Al-Samydai, Zainab Zaki Zakaraya, Wael Abu Dayyih
Summary: Parabens, including their derivatives, are commonly used in cosmetics and healthcare products for their preservative and antimicrobial properties. They are compatible with different cosmetic formulations and are cost-effective. However, concerns have been raised about their safety after detecting them in biological tissues following long-term use, especially in relation to breast cancer. As a response, regulatory authorities worldwide have established limitations on the concentrations of parabens allowed in cosmetic products.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Critical Care Medicine
Ali Al-Samydai, Maha N. Abu Hajleh, Amal Mayyas, Farah Al-Mamoori, Deniz M. Al-Tawalbe, Moath Alqaraleh, Mohamad Ak Mousa, Hala Aladwan, Badi'ah Alazab, Dana Selwadi, Fatimah Akram Othman, Mohamed Sayed Zaazouee, Khaled Mohamed Ragab, Lidia Al-Halaseh
Summary: Traditional healers in rural areas provide healthcare and home remedies based on cultural beliefs. Patients in the Mediterranean region depend on traditional medicine for treating skin burns. This study surveyed traditional healers' practices for treating skin burns in 18 Arab countries. The survey collected data from 7530 participants in Asian and African countries. The findings revealed the use of various medicinal plants and herbal remedies, such as olive oil and aloe vera, for reducing inflammation and pain in burn treatment.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maha N. Abu Hajleh, Muhamad Al-limoun, Amjad Al-Tarawneh, Tahani J. Hijazin, Moath Alqaraleh, Khaled Khleifat, Osama Y. Al-Madanat, Yaseen Al Qaisi, Ahmad AlSarayreh, Ali Al-Samydai, Haitham Qaralleh, Emad A. S. Al-Dujaili
Summary: The study focuses on the biosynthesis of AgNPs using Emericella dentata and their combination with synthesized biochar. The synergistic effects of AgNPs and biochar were evaluated through various assessments, including pro-inflammatory cytokines, anti-apoptotic gene expression, and antibacterial activity. The results showed that the combined material exhibited enhanced antibacterial efficacy and reduced expression of anti-apoptotic genes and pro-inflammatory cytokines, suggesting its potential use in combating lung cancer epithelial cells and pathogenic bacteria.
Article
Nutrition & Dietetics
Nafe M. Al-Tawarah, Rawand H. Al-dmour, Maha N. Abu Hajleh, Khaled M. Khleifat, Moath Alqaraleh, Yousef M. Al-Saraireh, Ahmad Q. Jaradat, Emad A. S. Al-Dujaili
Summary: This study investigated the nootropic and anti-amnesic effects of peppermint and rosemary oils in a rat model of Alzheimer's disease. Both oils were found to improve working memory, spatial memory, and long-term memory. They also increased BDNF levels in the hippocampus and suppressed neurogenesis, and the combination of the two oils enhanced their anti-amnesic activity. The chemical compounds in the oils showed potential efficacy in memory processes and cognitive defects.
Article
Infectious Diseases
Moath Alqaraleh, Khaled M. Khleifat, Maha N. Abu Hajleh, Husni S. Farah, Khaled Abdul-Aziz Ahmed
Summary: The combination of biochar and AgNPs showed enhanced antibacterial activity and antiproliferative effects against colorectal cancer cells. Furthermore, this combination significantly reduced the expression levels of VEGF and proinflammatory cytokines. These findings suggest that biochar and AgNPs may serve as novel treatments for bacteria and colorectal cancer cells.
Article
Multidisciplinary Sciences
Ali Al-Samydai, Moath Al Qaraleh, Khaldun M. Al Azzam, Amal Mayyas, Hamdi Nsairat, Maha N. Abu Hajleh, Lidia K. Al-Halaseh, Nehaya Al-Karablieh, Amal Akour, Fatima Alshaik, Walhan Alshaer
Summary: Cancer is a leading cause of death worldwide, and natural products such as gallic acid and quercetin have shown potential in cancer treatment due to their antioxidant, antibacterial, and neoplastic properties. This research aims to develop a novel formulation of co-loaded gallic acid and quercetin and study their effectiveness against cancer cells and bacterial strains.
Article
Biochemical Research Methods
Rand Alquraishi, Ali Al-samydai, Khaldun M. Al Azzam, Moath Alqaraleh, Lidia Al-Halaseh, Alaa Sanabrah, Maha N. Abu Hajleh, Arwa Al Khatib, Walhan Alsaher, El-Sayed Negim, Khaled Khleifat
Summary: Chronic wounds, such as diabetic foot ulcers, venous leg ulcers and pressure ulcers, are a major concern in healthcare systems. Oleuropein, extracted from olive leaves, has the potential to improve wound healing due to its antioxidant effect. However, the poor pharmacokinetics of oleuropein limit its clinical use. This study investigates the impact of PEGylated and non-PEGylated nanoliposomes loaded with oleuropein on wound-healing activity. The results suggest that non-PEGylated compositions have higher encapsulation efficiency and PEGylated liposomal compositions exhibit faster wound healing activity.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Tabarek H. Mahmood, Ali Al-Samydai, Mazen Al Sulaibi, Moath Alqaraleh, Anas Ibrahim Abed, Naeem Shalan, Alaa Alsanabrah, Shrouq Taiseer Alsotari, Hamdi Nsairat, Walhan Alshaer
Summary: Olive leaf extract is rich in phenolic compounds, primarily oleuropein and rutin. Loading them into PEGylated Nano-phytosomes enhances their anticancer activity and stability, surpassing that of pure oleuropein and rutin alone. This study presents a promising pathway for the future development of oleuropein and rutin Nano-phytosomes as effective options for passive tumor-targeted therapy.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Pharmacology & Pharmacy
Rana Abu-Huwaij, Adian Alkarawi, Dima Salman, Furqan Alkarawi
Summary: Dermal drug delivery through the use of niosomes, self-assembled vesicular structures, has shown promise in overcoming the barrier of the stratum corneum. This review provides an overview of the current research on niosomes in dermal drug delivery, focusing on their formulation, characterization, and application in delivering various drug classes in cosmetics. The review highlights the advantages of niosomes over traditional drug delivery methods, such as improved drug solubility and stability, controlled release, and enhanced skin permeation. Challenges associated with niosome-based drug delivery, including complex formulation and the need for further safety and toxicity studies, are also discussed.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Review
Dermatology
Rana Abu-Huwaij, Abdullah N. Zidan
Summary: This review provides a comprehensive overview of ethosomes as an effective nanocarrier for delivering active ingredients to the skin. Ethosomes are composed of high concentrations of ethanol and phospholipids, making them an ideal choice for targeted treatment. Despite the challenges associated with their preparation, ethosomes hold great potential in the treatment of hair loss, acne, and skin whitening.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Health Care Sciences & Services
Ra'ed M. Shudifat, Sultan Mosleh, Suhair Almakhzomi, Mohammad Al Shdifat, Malek Alnajar, Ja'far M. Alkhawaldeh, Lidia K. Al-Halaseh
Summary: This study assessed the perception and awareness level of health science students towards using over-the-counter (OTC) medicines and identified potential malpractice. The results showed that most participants rely on OTC medicines for minor conditions and have a positive attitude towards self-treatment. However, there was no significant association between attitude score and participant age, gender, academic level, or college. It is necessary to introduce interprofessional medical education to ensure that medical students have integrated knowledge and skills needed to provide the best health services.
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Rawan Al-Suhaimat, Lidia K. Al-Halaseh, Ali Al-Samydai
Summary: The study shows a moderate correlation between pharmacists' experience, knowledge, continuing learning, attitude, and practice with early diagnosis and patient compliance of celiac disease. Some participants acknowledge their lack of knowledge regarding symptoms, but most are willing to participate in educational programs.
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2023)
