Article
Biochemistry & Molecular Biology
Zhihuang Zheng, Yao Xu, Ute Krugel, Michael Schaefer, Tilman Grune, Bernd Nurnberg, May-Britt Kohler, Maik Gollasch, Dmitry Tsvetkov, Lajos Marko
Summary: The pharmacological inhibition of TRPC6 has shown promising results in ameliorating renal fibrosis and inflammation in a mouse model of metabolic syndrome. The study suggests that targeting TRPC6 could be a potential therapeutic method for treating progressive tubulo-interstitial fibrosis in hypertension and metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yan Mao, Jiali Yu, Jingjing Da, Fuxun Yu, Yan Zha
Summary: This study aimed to investigate the effects of Acteoside on UUO rats and its possible mechanisms. The results showed that Acteoside improved renal function by reducing serum creatinine, blood urea nitrogen and urine protein. It also alleviated renal inflammation and fibrosis, and reduced the expression of inflammation and fibrosis-related proteins. In addition, Acteoside reduced the expression of HMGN1, TLR4, and TREM-1 proteins. These findings suggest that Acteoside ameliorates UUO-induced renal inflammation and fibrosis through the HMGN1/TLR4/TREM-1 pathway.
Article
Nutrition & Dietetics
Jonas Laget, Irene Cortijo, Juliana H. H. Boukhaled, Karen Muyor, Flore Duranton, Bernard Jover, Fabrice Raynaud, Anne-Dominique Lajoix, Angel Argiles, Nathalie Gayrard
Summary: Obesity exacerbates renal inflammation and fibrosis in chronic kidney disease (CKD). Certain substances such as interleukin 11, dipeptidyl peptidase 4, and serpin 1 may directly affect the process of fibrosis.
Article
Biochemistry & Molecular Biology
Sun-Jae Lee, Young-Ah Kim, Kwan-Kyu Park
Summary: This study explored the preventive effects of TFEB suppression on renal fibrosis through injecting synthesized TFEB decoy ODNs into UUO mice. The results showed that TFEB inhibition not only reduced fibrosis and autophagy but also exhibited anti-inflammatory effects. These findings suggest that regulating TFEB activity may be a promising therapeutic strategy against kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Young-Ah Kim, Hyun-Ju Kim, Mi-Gyeong Gwon, Hyemin Gu, Hyun-Jin An, Seongjae Bae, Jaechan Leem, Hyun Jin Jung, Kwan-Kyu Park
Summary: Our study demonstrated that synthesized STAT3 decoy oligonucleotides could reduce the expression of fibrotic factors such as IL-6, IL-1 beta, TNF-alpha, and collagen; immunofluorescent staining showed a decrease in markers of autophagy like LC3 and fibronectin in the ODN injection group; the expressions of LC3, Beclin1, p62, Atg5-12, and HIF-1 alpha were inhibited in the ODN injection group, indicating an inhibitory effect on autophagy.
Article
Cell Biology
Junjun Luan, Jingqi Fu, Congcong Jiao, Xiangnan Hao, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Guangyu Zhou, Hongyu Li, Wei Yang, Peter S. T. Yuen, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Summary: This study investigated the role of interleukin-18 (IL-18) in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The results showed that IL-18 deficiency can attenuate renal tubular damage, necroptosis, cell transdifferentiation, and fibrosis, and this renoprotective effect may be mediated by reducing the switch from M1 to profibrotic M2 macrophages.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yong-Ke You, Wei-Feng Wu, Xiao-Ru Huang, Hai-Di Li, Ye-Ping Ren, Jin-Cheng Zeng, Haiyong Chen, Hui Yao Lan
Summary: Elevated plasma levels of CRP are closely associated with progressive renal injury in CKD patients, and this study found that CRP may promote renal fibrosis and inflammation via a TGF-beta/Smad3-dependent mechanism. Smad3 deficiency protects against CRP-mediated renal inflammation and fibrosis by inactivating CD32-NF-kappa B and TGF-beta/Smad3 signaling in the UUO kidney.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Suyeon Han, Hyunsu Choi, Hyerim Park, Jwa-Jin Kim, Eu-Jin Lee, Young-Rok Ham, Ki-Rayng Na, Kang-Wook Lee, Yoon-Kyung Chang, Dae-Eun Choi
Summary: This study found that omega-3 polyunsaturated fatty acids (PUFAs) can attenuate kidney injury caused by unilateral ureteral obstruction (UUO) and exert their effects by enhancing autophagy.
Article
Immunology
Wu Chen, Sheng Zhao, Ji Xing, Xiangjun Zhou, Siqi Li, Yuqi Xia, Tianbao Song, Wei Li, Fan Zou, Fan Cheng
Summary: This study found that BMAL1 is involved in the regulation of renal fibrosis and renal interstitial inflammation in obstructed kidneys. Downregulation of BMAL1 promoted the production of extracellular matrix proteins and proinflammatory factors, while upregulation inhibited this process. The ERK1/2/ELK-1/Egr-1 axis was identified as an important pathway for BMAL1 to play a regulatory role.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Young-Ah Kim, Hyemin Gu, Mi-Gyeong Gwon, Hyun-Jin An, Seongjae Bae, Jaechan Leem, Hyun Jin Jung, Kwan-Kyu Park, Sun-Jae Lee
Summary: The study found that ring-type ODNs can suppress chronic renal injury by reducing inflammation, fibrosis, and autophagy. This suggests that regulating mTOR signaling could be a therapeutic strategy for treating chronic kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cleo C. L. van Aanhold, Angela Koudijs, Kyra L. Dijkstra, Ron Wolterbeek, Jan A. Bruijn, Cees van Kooten, Hans J. Baelde
Summary: The study found that transfection with sFLT1 did not aggravate renal fibrosis and peritubular capillary loss, but reduced the expression of pro-fibrotic and pro-inflammatory markers. sFLT1 mRNA levels were not correlated with interstitial fibrosis or PTC loss in human samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Reynold I. I. Lopez-Soler, Azadeh Nikouee, Matthew Kim, Saman Khan, Lakshmi Sivaraman, Xiangzhong Ding, Qun Sophia Zang
Summary: This study found that enhancing autophagy can reduce fibrosis caused by renal injury. By observing mice after kidney surgery, it was found that the use of active mutant Beclin-1 can inhibit the fibrosis process, alleviate inflammation and cellular stress response caused by kidney injury. These findings provide new methods for treating fibrosis after kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Bingwen Zhu, Rangyue Han, Yufang Ni, Huaiying Guo, Xiaoheng Liu, Jianchun Li, Li Wang
Summary: Podocarpusflavone (POD) exerts a protective effect on renal fibrosis by mediating the Fyn/Stat3 signaling pathway.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Cell Biology
Yanhong Zhang, Nina Yin, Anbang Sun, Qifang Wu, Wenzhu Hu, Xin Hou, Xixi Zeng, Min Zhu, Yanhong Liao
Summary: Kidney fibrosis plays a significant role in chronic kidney disease, and EMT is an important molecular mechanism contributing to fibrosis. The study suggests that TRPC6 knockout may ameliorate kidney fibrosis by inhibiting EMT and down-regulating the AKT-mTOR and ERK1/2 pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Fengyun Wang, Lixin Zhou, Amity Eliaz, Chang Hu, Xinhua Qiang, Li Ke, Glenn Chertow, Isaac Eliaz, Zhiyong Peng
Summary: Acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with high morbidity and mortality. Galectin-3 (Gal3), a protein with proinflammatory and profibrotic properties, has been implicated in the development and progression of both AKI and CKD. Elevated Gal3 levels in the serum of AKI and CKD patients and its association with CKD progression have been observed. Gal3 is also associated with AKI incidence in critically ill patients, and blocking Gal3 has shown promising results in reducing AKI incidence and mortality in animal models.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell Biology
Jingyu Wang, Yi Liu, Yaqing Wang, Li Sun
Summary: Acute and chronic kidney injuries are caused by structural dysfunction and metabolic disorders of the kidney, significantly impacting human survival and social wealth. Recent studies have discovered nontraditional forms of cell death such as ferroptosis and necroptosis in kidney diseases, reshuffling the role of traditional cell death. Although research on ferroptosis and acute kidney injury (AKI) is ongoing, studies on ferroptosis and chronic kidney disease (CKD) remain limited.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Oncology
Xin Huang, Jingyu Wang, Jibin Guan, Zhong Zheng, JunFeng Hao, Zitong Sheng, Menghua Wang, Tianhua Xu, Guangying Guo, Li Yao
Summary: This study identified the high expression of circRNA SAFB2 in RCC tissues and RCC-derived exosomes. It further demonstrated that exosomal circRNA SAFB2 mediates the polarization of M2 macrophages through the miR-620/JAK1/STAT3 axis, promoting RCC metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Jingyu Wang, Yaqing Wang, Yi Liu, Xintian Cai, Xin Huang, Wenjing Fu, Lei Wang, Lihua Qiu, Junying Li, Li Sun
Summary: This study reveals the involvement of ferroptosis in the progression of chronic kidney disease and suggests it as a potential therapeutic target for chronic kidney injury and renal fibrosis.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Xintian Cai, Junli Hu, Wen Wen, Jingyu Wang, Mengru Wang, Shasha Liu, Qing Zhu, Jing Hong, Yujie Dang, Xiaoguang Yao, Le Sun, Delian Zhang, Qin Luo, Nanfang Li
Summary: This study aimed to investigate the relationship between cardiometabolic index (CMI) and cardiovascular disease (CVD) and its subtypes (coronary artery disease and stroke) in patients with hypertension and obstructive sleep apnea (OSA). The results showed a positive association between CMI levels and the risk of new-onset CVD, suggesting that CMI may help identify individuals at high risk of developing CVD.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Anesthesiology
Yi Liu, Jingyu Wang, Yuan Geng, Yiran Zhang, Hang Su, Yujiao Yang
Summary: This study demonstrated that the combination of recruitment maneuvers and positive end-expiratory pressure can reduce the incidence of atelectasis in patients with healthy lungs within 15 minutes of arrival in the post-anesthesia care unit (PACU) during gynecologic laparoscopic surgery. However, this effect disappeared after 24 hours of surgery.
BMC ANESTHESIOLOGY
(2022)
Review
Cell Biology
Yi Liu, Jingyu Wang
Summary: Ferroptosis is a programmed cell death associated with iron overload, oxidative stress, and imbalance in lipid repair, and it plays a crucial role in the progression of fibrotic diseases. Targeting ferroptosis can effectively alleviate kidney injury and fibrosis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Peripheral Vascular Disease
Dikang Pan, Jiabin Wang, Julong Guo, Zhixiang Su, Jingyu Wang, Jianming Guo, Xiaoming Shi, Yongquan Gu
Summary: The prevalence of peripheral artery disease is increasing and leads to significant amputations and mortality. Frailty is a major risk factor for adverse outcomes in managing this vascular disease. The geriatric nutritional risk index can predict adverse outcomes in lower extremity peripheral artery disease and is a nutrition-based measure for frailty. In this study, malnutrition based on the geriatric nutritional risk index was found to be an independent predictor of major adverse limb events. Future research should focus on identifying and modifying risk factors to improve long-term outcomes in these patients.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Environmental Sciences
Baoluo Ma, Linghui Qin, Zhou Sun, Jingyu Wang, Lisa Jia Tran, Jing Zhang, Fangdie Ye, Yan Liu, Min Chen
Summary: This study identified multiple hypoxia-related tumor microenvironment (TME) cell subclusters in clear cell renal cell carcinoma (ccRCC), which displayed distinct functional features and great potential for predicting the prognosis of ccRCC patients. The role of ANGPTL4 in regulating ccRCC proliferation via the ERK/p38 pathway was also identified.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Dikang Pan, Julong Guo, Zhixiang Su, Jingyu Wang, Sensen Wu, Jianming Guo, Yongquan Gu
Summary: A study analyzed data from 3763 adult patients with type 2 diabetes from 1999 to 2018 and found that the Controlling Nutritional Status (CONUT) score was associated with all-cause mortality and cancer mortality in these patients. During the mean follow-up of 8.17 years, 823 deaths from all causes and 155 deaths from cancer were recorded. Patients with a Mild (CONUT score ≥ 2) had a 39% higher risk of all-cause mortality and a 45% higher risk of cancer mortality compared to patients with a Normal (CONUT score 0-1).
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Yachan Ning, Dikang Pan, Julong Guo, Zhixiang Su, Jingyu Wang, Sensen Wu, Yongquan Gu
Summary: This study found that lower serum PNI levels were significantly associated with higher all-cause and cardiovascular mortality in patients with diabetes. Maintaining an appropriate range of serum PNI status may reduce the risk of death in these patients.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Cell Biology
Xintian Cai, Junli Hu, Mengru Wang, Wen Wen, Jingyu Wang, Wenbo Yang, Yujie Dang, Qin Luo, Jing Hong, Nanfang Li
Summary: This study aimed to determine the relationship between sarcopenia index (SI) and stroke risk in elderly hypertensive patients. The study included 5145 stroke-free elderly hypertensive patients. Results showed that a higher SI was associated with a decreased risk of stroke in elderly patients with hypertension. Further prospective studies are needed to establish the causality behind this relationship.
Article
Urology & Nephrology
Jingyu Wang, Xingzi Liu, Dikang Pan, Xintian Cai, Yuzhou Xue, Jing Huang
Summary: This study uses bibliometric analysis and visualization to summarize the current status and frontiers of research on COVID-19 in relation to chronic kidney disease. The results show a high level of international collaboration, with the USA, China, and the UK being the top publishing countries and Harvard Medical School being the top publishing institution. Thrombosis, telemedicine, depression, and COVID-19 vaccines are identified as current hot topics in the field.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Jingyu Wang, Xin Wang, Xintian Cai, Dikang Pan
Summary: This study aims to investigate the distribution patterns and research frontiers of international literature on IgA nephropathy. The results show that China has the highest number of publications in this field, and Peking University is the institution with the most publications. The current research hotspots and frontiers mainly focus on multicenter studies related to IgA nephropathy and its exploration with gut microbiota.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)