Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development

Swertiamarin, a secoiridoid glycoside modulates nAChR and AChE activity

(2020) Taruna Pandey et al.   EXPERIMENTAL GERONTOLOGY

Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway

(2019) Hui Wang et al.   ACS Chemical Neuroscience

Molecular docking, antiproliferative and anticonvulsant activities of swertiamarin isolated from Enicostemma axillare

(2019) Jaishree Vaijanathappa et al.   BIOORGANIC CHEMISTRY

A natural AKT inhibitor swertiamarin targets AKT‐PH domain, inhibits downstream signaling, and alleviates inflammation

(2019) Man Zhang et al.   FEBS Journal

Pharmacokinetics and metabolic profiles of swertiamarin in rats by liquid chromatography combined with electrospray ionization tandem mass spectrometry

(2019) Mengge Shi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer

(2019) Puvanesswaray Ramakrishnan et al.   Acta Pharmaceutica Sinica B

What has come out from phytomedicines and herbal edibles for the treatment of cancer?

(2018) Srinivasa Reddy Bonam et al.   ChemMedChem

The Molecular Targets of Swertiamarin and its Derivatives Confer Anti- Diabetic and Anti-Hyperlipidemic Effects

(2018) Naisargee Patel et al.   CURRENT DRUG TARGETS

Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice

(2018) Yang Yang et al.   PHYTOMEDICINE

Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling

(2017) M.I. Hairul-Islam et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anticonvulsant Effect of Swertiamarin Against Pilocarpine-Induced Seizures in Adult Male Mice

(2017) Xian-Hua Deng et al.   NEUROCHEMICAL RESEARCH

Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis

(2016) Tushar P. Patel et al.   BIOMEDICINE & PHARMACOTHERAPY

Baccharis(Asteraceae): Chemical Constituents and Biological Activities

(2016) Francinete Ramos Campos et al.   CHEMISTRY & BIODIVERSITY

High-throughput sequencing and de novo transcriptome assembly of Swertia japonica to identify genes involved in the biosynthesis of therapeutic metabolites

(2016) Amit Rai et al.   PLANT CELL REPORTS

Amelioration of oxidative and inflammatory changes by Swertia chirayita leaves in experimental arthritis

(2016) Harsha Lad et al.   INFLAMMOPHARMACOLOGY

New analytical method for the study of metabolism of swertiamarin in rats after oral administration by UPLC-TOF-MS following DNPH derivatization

(2015) Xiuhong Wu et al.   BIOMEDICAL CHROMATOGRAPHY

Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity

(2015) Tuan-Wu Cao et al.   FITOTERAPIA

RP-HPLC analysis of seco-iridoid glycoside swertiamarin from differentSwertiaspecies

(2015) Parthraj R. Kshirsagar et al.   NATURAL PRODUCT RESEARCH

IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy

(2015) Irem Fatma Uludag et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Correlation Between IL-10 and microRNA-187 Expression in Epileptic Rat Hippocampus and Patients with Temporal Lobe Epilepsy

(2015) Walid A. Alsharafi et al.   Frontiers in Cellular Neuroscience

Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced β-cell damage in Wistar rat pancreas

(2015) G. Dhanavathy   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κB and JAK2/STAT3 transcription factors in adjuvant induced arthritis

(2014) S. Saravanan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In Vivo and In Vitro Immunomodulatory Potential of Swertiamarin Isolated from Enicostema axillare (Lam.) A. Raynal That Acts as an Anti-inflammatory Agent

(2014) S. Saravanan et al.   INFLAMMATION

Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1β induced rat fibroblast-like synoviocytes

(2014) S. Saravanan et al.   INFLAMMATION RESEARCH

The hepatoprotective effect and chemical constituents of total iridoids and xanthones extracted from Swertia mussotii Franch

(2014) Chengwang Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

RETRACTED: Anti-diabetic activity of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke aerial parts extract in streptozotocin induced diabetic rats

(2014) G. Mahendran et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats

(2014) Vladimir Mihailović et al.   Food & Function

In silico docking studies for designing potent anti-diabetic derivatives of swertiamarin with enzyme HMG COA reductase

(2014) Jayshil Bhatt et al.   Molecular Cytogenetics

Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

(2014) Xiaoxuan Zhu et al.   Frontiers of Medicine

Rigenolide A, a new secoiridoid glucoside with a cyclobutane skeleton, and three new acylated secoiridoid glucosides from Gentiana rigescens Franch

(2013) Yoshihiro Suyama et al.   FITOTERAPIA

Comparative pharmacokinetics of swertiamarin in rats after oral administration of swertiamarin alone, Qing Ye Dan tablets and co-administration of swertiamarin and oleanolic acid

(2013) Gui-li Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (ΔΨm) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents

(2013) Bilal A. Wani et al.   PHYTOMEDICINE

Inhibition of Vascular Smooth Muscle Cell Proliferation by Gentiana lutea Root Extracts

(2013) Rushendhiran Kesavan et al.   PLoS One

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Anti-diabetic Activity of Swertiamarin is due to an Active Metabolite, Gentianine, that Upregulates PPAR-γ Gene Expression in 3T3-L1 cells

(2012) Hitesh Vaidya et al.   PHYTOTHERAPY RESEARCH

Beneficial Effects of Swertiamarin on Dyslipidaemia in Streptozotocin-induced Type 2 Diabetic Rats

(2012) Hitesh Vaidya et al.   PHYTOTHERAPY RESEARCH

Phenolic-Linked Biochemical Rationale for the Anti-Diabetic Properties ofSwertia chirayita(Roxb. ex Flem.) Karst.

(2012) Susanna Phoboo et al.   PHYTOTHERAPY RESEARCH

Epilepsy and brain inflammation

(2011) Annamaria Vezzani et al.   EXPERIMENTAL NEUROLOGY

Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice

(2011) Yoshiyuki Kimura et al.   FITOTERAPIA

Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against d-galactosamine induced acute liver damage in rats

(2010) V. Jaishree et al.   JOURNAL OF ETHNOPHARMACOLOGY

Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats

(2010) Rakesh D. Sonawane et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Further studies on the chemical constituents of Chinese folk medicineGentiana apiataN.E. Br.

(2009) Le Zhou et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Fagraldehyde, a Secoiridoid Isolated fromFagraeafragrans

(2008) Marie-Caroline Jonville et al.   JOURNAL OF NATURAL PRODUCTS

Antinociceptive activity of swertiamarin isolated from Enicostemma axillare

(2008) V. Jaishree et al.   PHYTOMEDICINE

The Leaf Epidermome of Catharanthus roseus Reveals Its Biochemical Specialization

(2008) J. Murata et al.   PLANT CELL

Antiedematogenic and Free Radical Scavenging Activity of Swertiamarin Isolated fromEnicostemma axillare

(2008) Jaishree Vaijanathappa et al.   PLANTA MEDICA