High-resolution characterization of gene function using single-cell CRISPR tiling screen
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
High-resolution characterization of gene function using single-cell CRISPR tiling screen
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-07-01
DOI
10.1038/s41467-021-24324-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing
- (2020) Joseph M. Replogle et al. NATURE BIOTECHNOLOGY
- A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens
- (2019) Molly Gasperini et al. CELL
- Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L
- (2019) Evan J. Worden et al. CELL
- Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination
- (2019) Marco Igor Valencia-Sánchez et al. MOLECULAR CELL
- Next-generation characterization of the Cancer Cell Line Encyclopedia
- (2019) Mahmoud Ghandi et al. NATURE
- Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions
- (2019) Anthony K. N. Chan et al. Frontiers in Cell and Developmental Biology
- A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition
- (2019) José L. McFaline-Figueroa et al. NATURE GENETICS
- CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons
- (2019) Ruilin Tian et al. NEURON
- Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
- (2019) Thomas M. Norman et al. SCIENCE
- De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens
- (2019) Wei He et al. Nature Communications
- The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia
- (2018) Eytan M. Stein et al. BLOOD
- Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis
- (2018) Heng Zhang et al. GENES & DEVELOPMENT
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis
- (2018) Amir Giladi et al. NATURE CELL BIOLOGY
- RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy
- (2018) Stephen K Burley et al. NUCLEIC ACIDS RESEARCH
- Transcription control by the ENL YEATS domain in acute leukaemia
- (2017) Michael A. Erb et al. NATURE
- Pooled CRISPR screening with single-cell transcriptome readout
- (2017) Paul Datlinger et al. NATURE METHODS
- Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis
- (2017) Jonathan J. Ipsaro et al. PLoS One
- Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq
- (2016) Diego Adhemar Jaitin et al. CELL
- A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
- (2016) Britt Adamson et al. CELL
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions
- (2016) D. M. Munoz et al. Cancer Discovery
- Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond
- (2015) Chun-Wei Chen et al. EXPERIMENTAL HEMATOLOGY
- BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
- (2015) Matthew C. Canver et al. NATURE
- Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
- (2015) Junwei Shi et al. NATURE BIOTECHNOLOGY
- DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
- (2015) Chun-Wei Chen et al. NATURE MEDICINE
- The I-TASSER Suite: protein structure and function prediction
- (2015) Jianyi Yang et al. NATURE METHODS
- High-throughput functional genomics using CRISPR–Cas9
- (2015) Ophir Shalem et al. NATURE REVIEWS GENETICS
- Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential
- (2015) Aravinda Kuntimaddi et al. Cell Reports
- AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes
- (2014) Aniruddha J. Deshpande et al. CANCER CELL
- The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
- (2014) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- Scalable web services for the PSIPRED Protein Analysis Workbench
- (2013) Daniel W. A. Buchan et al. NUCLEIC ACIDS RESEARCH
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
- (2011) Kathrin M. Bernt et al. CANCER CELL
- Accelerating Protein Docking in ZDOCK Using an Advanced 3D Convolution Library
- (2011) Brian G. Pierce et al. PLoS One
- Characterization of the DOT1L Network: Implications of Diverse Roles for DOT1L
- (2010) Geunyeong Park et al. PROTEIN JOURNAL
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
- (2009) Ben Langmead et al. GENOME BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search