Quantitative modelling of amino acid transport and homeostasis in mammalian cells

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

(2021) Margaret E Torrence et al.   eLife

A GC-MS/Single-Cell Method to Evaluate Membrane Transporter Substrate Specificity and Signaling

(2021) Stephen J. Fairweather et al.   Frontiers in Molecular Biosciences

Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis

(2020) Avlant Nilsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How

(2020) Stefan Bröer   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9

(2020) Simon A. Fromm et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells

(2019) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

(2019) Ekaitz Errasti-Murugarren et al.   Nature Communications

Multifaceted regulation of the system A transporter Slc38a2 suggests nanoscale regulation of amino acid metabolism and cellular signaling

(2019) Robin Johansen Menchini et al.   NEUROPHARMACOLOGY

Mice Lacking the Intestinal and Renal Neutral Amino Acid Transporter SLC6A19 Demonstrate the Relationship between Dietary Protein Intake and Amino Acid Malabsorption

(2019) Kiran Javed et al.   Nutrients

DExSI: a new tool for the rapid quantitation of 13C-labelled metabolites detected by GC-MS

(2018) Michael J Dagley et al.   BIOINFORMATICS

PATs and SNATs: Amino Acid Sensors in Disguise

(2018) Shih-Jung Fan et al.   Frontiers in Pharmacology

SNAT3-mediated glutamine transport in perisynaptic astrocytes in situ is regulated by intracellular sodium

(2017) Alison C. Todd et al.   GLIA

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells

(2016) Elina Timosenko et al.   CANCER RESEARCH

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Extraction parameters for metabolomics from cultured cells

(2015) Zheng Ser et al.   ANALYTICAL BIOCHEMISTRY

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

(2015) Jennifer Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Transport mechanism and regulatory properties of the human amino acid transporter ASCT2 (SLC1A5)

(2014) Mariafrancesca Scalise et al.   AMINO ACIDS

Loratadine and Analogues: Discovery and Preliminary Structure–Activity Relationship of Inhibitors of the Amino Acid Transporter B0AT2

(2014) Serena Cuboni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris — functional and kinetic asymmetry revealed in proteoliposomes

(2013) Piero Pingitore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

The SLC38 family of sodium–amino acid co-transporters

(2013) Stefan Bröer   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells

(2012) Michael S. Kilberg et al.   Advances in Nutrition

Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound

(2011) Michael F. Wempe et al.   Drug Metabolism and Pharmacokinetics

Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

(2010) Cédric Chaveroux et al.   BIOCHIMIE

Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)

(2010) Mette N. Erichsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

(2009) Harinder S. Hundal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles

(2009) Bianca Maria Rotoli et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA