KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals

The store-operated Ca2+ entry complex comprises a small cluster of STIM1 associated with one Orai1 channel

(2021) Yihan Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release

(2020) Jeffrey T Lock et al.   eLife

ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein

(2020) Horia Vais et al.   eLife

Spatial-temporal patterning of Ca2+ signals by the subcellular distribution of IP3 and IP3 receptors

(2019) Jeffrey T. Lock et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis

(2019) Fang Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

(2019) Adam Bartok et al.   Nature Communications

Dynamic Ca 2+ imaging with a simplified lattice light-sheet microscope: A sideways view of subcellular Ca 2+ puffs

(2018) Kyle L. Ellefsen et al.   CELL CALCIUM

The actin cortex at a glance

(2018) Priyamvada Chugh et al.   JOURNAL OF CELL SCIENCE

Regulation of actin assembly by PI(4,5)P2 and other inositol phospholipids: An update on possible mechanisms

(2018) Paul A. Janmey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

All three IP3receptor subtypes generate Ca2+puffs, the universal building blocks of IP3-evoked Ca2+signals

(2018) Stefania Mataragka et al.   JOURNAL OF CELL SCIENCE

The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion

(2018) Marco Padilla-Rodriguez et al.   Nature Communications

IP3 receptors – lessons from analyses ex cellula

(2018) Ana M. Rossi et al.   JOURNAL OF CELL SCIENCE

All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics

(2018) Jeffrey T. Lock et al.   Science Signaling

IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes

(2018) Peace Atakpa et al.   Cell Reports

IP3 receptors and store-operated Ca2+ entry: a license to fill

(2018) Colin W Taylor et al.   CURRENT OPINION IN CELL BIOLOGY

DiAna, an ImageJ tool for object-based 3D co-localization and distance analysis

(2017) Jean-François Gilles et al.   METHODS

Cortical actin contributes to spatial organization of ER–PM junctions

(2017) Ting-Sung Hsieh et al.   MOLECULAR BIOLOGY OF THE CELL

Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors

(2017) Jingjing Liang et al.   Nature Communications

Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions

(2017) Nagendra Babu Thillaiappan et al.   Nature Communications

Classification and Segmentation of Nanoparticle Diffusion Trajectories in Cellular Micro Environments

(2017) Thorsten Wagner et al.   PLoS One

Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs

(2016) David L. Prole et al.   JOURNAL OF PHYSIOLOGY-LONDON

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

Global, quantitative and dynamic mapping of protein subcellular localization

(2016) Daniel N Itzhak et al.   eLife

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

The STIM1–ORAI1 microdomain

(2015) Patrick G Hogan   CELL CALCIUM

Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function

(2015) Jason Lowery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Molecule Tracking of Inositol Trisphosphate Receptors Reveals Different Motilities and Distributions

(2014) Ian F. Smith et al.   BIOPHYSICAL JOURNAL

An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging

(2014) Kyle L. Ellefsen et al.   CELL CALCIUM

Reliable Encoding of Stimulus Intensities Within Random Sequences of Intracellular Ca2+ Spikes

(2014) K. Thurley et al.   Science Signaling

Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux

(2013) Hiroshi Matsuzaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Actin Cytoskeleton Rest Stops Regulate Anterograde Traffic of Connexin 43 Vesicles to the Plasma Membrane

(2012) James W. Smyth et al.   CIRCULATION RESEARCH

Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney

(2012) TAKAHIRO FUJIMOTO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cooperative and Stochastic Calcium Releases from Multiple Calcium Puff Sites Generate Calcium Microdomains in Intact HeLa Cells

(2012) Hideki Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

(2012) Di Wang et al.   NATURE IMMUNOLOGY

Resolution doubling in live, multicellular organisms via multifocal structured illumination microscopy

(2012) Andrew G York et al.   NATURE METHODS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release

(2011) Takahiro Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Determination of the critical region of KRAS-induced actin-interacting protein for the interaction with inositol 1,4,5-trisphosphate receptor

(2011) Takahiro Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells

(2011) Takahiro Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential Distribution, Clustering, and Lateral Diffusion of Subtypes of the Inositol 1,4,5-Trisphosphate Receptor

(2011) Evangelia Pantazaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superresolution Localization of Single Functional IP3R Channels Utilizing Ca2+ Flux as a Readout

(2010) Steven M. Wiltgen et al.   BIOPHYSICAL JOURNAL

Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp

(2010) Ian Parker et al.   JOURNAL OF GENERAL PHYSIOLOGY

Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 in Purkinje cells is regulated by calcium and actin filaments

(2010) Kazumi Fukatsu et al.   JOURNAL OF NEUROCHEMISTRY

Inositol 1,4,5-Triphosphate Receptor-binding Protein Released with Inositol 1,4,5-Triphosphate (IRBIT) Associates with Components of the mRNA 3′ Processing Machinery in a Phosphorylation-dependent Manner and Inhibits Polyadenylation

(2009) Hélène Kiefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Energy Homeostasis and Resistance to Diet-Induced Obesity in KRAP-Deficient Mice

(2009) Takahiro Fujimoto et al.   PLoS One

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

(2009) Y.-P. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells

(2009) I. F. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+ Puffs Originate from Preestablished Stable Clusters of Inositol Trisphosphate Receptors

(2009) I. F. Smith et al.   Science Signaling

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS

Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging

(2007) Angelo Demuro et al.   CELL CALCIUM