Article
Multidisciplinary Sciences
Irene Serra, Julio Esparza, Laura Delgado, Cristina Martin-Monteagudo, Margalida Puigros, Petar Podlesniy, Ramon Trullas, Marta Navarrete
Summary: This study demonstrates the importance of astrocytes in brain circuits and reveals the heterogeneity and plasticity of astrocytic networks. Using imaging techniques, the researchers identified specific neuron-astrocyte circuits in the NAc and showed non-linear calcium signaling integration in NAc astrocytes.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Aspen H. Yoo, Anne G. E. Collins
Summary: Reinforcement learning and working memory, though traditionally considered distinct processes in cognition, neuroscience, and algorithms, actually have overlapping brain networks and are not as separate as previously thought. Studies have shown the benefits of considering each process to explain properties of the other, with recent work highlighting their more complex interactions. The review underscores the importance of not neglecting the interplay between different processes when studying human behavior, emphasizing the need to investigate these dynamics for a comprehensive understanding of human cognition.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Aspen H. Yoo, Anne G. E. Collins
Summary: Reinforcement learning and working memory, two core processes of human cognition, are not as distinct as previously assumed, as their brain networks significantly overlap. Considering each process can explain properties of the other, and recent work has investigated their complex interactions.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Kirsten C. S. Adam, Rosanne L. L. Rademaker, John T. T. Serences
Summary: In this perspective, the authors discuss the tendency to use oversimplified and idiosyncratic tasks in the study of working memory. They highlight the importance of distributed, dynamic neural codes and the limitations of simplified tasks in understanding neural computations supporting behavior. The insights from Mark Stokes' work have pushed the field to explore multidimensional dynamics and move beyond static measures of working memory.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Jason Yuen, Abhinav Goyal, Aaron E. Rusheen, Abbas Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. Tye, Osama A. Abulseoud, Tyler S. Oesterle, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Yoonbae Oh, Hojin Shin
Summary: Opioids are the leading cause of overdose death in the United States, with nearly 70,000 deaths in 2020. Deep brain stimulation (DBS) is a promising treatment for substance use disorders. This study investigated the modulation of dopaminergic and respiratory effects of oxycodone by DBS of the ventral segmental area (VTA) in rodents. The results demonstrated that DBS reduced baseline dopamine levels and alleviated the increase in dopamine levels and respiratory depression induced by oxycodone.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Tao Xu, Jiajia Huang, Zian Pei, Jiaqing Chen, Junhua Li, Anastasios Bezerianos, Nitish Thakor, Hongtao Wang
Summary: This study aimed to explore the relationship between aging-related changes in working memory (WM) and brain functional networks. The experiment found that physiological aging affects brain network connectivity and decreases the differentiation of functional brain networks. There is an inverse relationship between alpha activity and WM load in the elderly group, which is absent in the young group. Theta band activity is correlated with behavioral performance in the elderly group with WM training, but not in the young group. Task difficulty and training have different effects on WM for different age groups.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Neurosciences
Gudrian Ricardo Lopes de Almeida, Jozimar Carlos Szczepanik, Ingrid Selhorst, Ariana Ern Schmitz, Barbara dos Santos, Mauricio Pena Cunha, Isabella Aparecida Heinrich, Gabriela Cristina de Paula, Andreza Fabro De Bem, Rodrigo Bainy Leal, Alcir Luiz Dafre
Summary: MGO, an endogenous toxin produced during glycolysis, has been linked to aging, Alzheimer's disease, and inflammation. In vivo administration of MGO affects monoaminergic systems in the cerebral cortex, leading to depression-like behavior and cognitive impairment. Treatment with a dopamine/noradrenaline reuptake inhibitor can reverse these effects.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Anais Llorens, Ludovic Bellier, Alejandro O. Blenkmann, Jugoslav Ivanovic, Pal G. Larsson, Jack J. Lin, Tor Endestad, Anne-Kristin Solbakk, Robert T. Knight
Summary: This study investigates the spatiotemporal dynamics in the insula during a verbal working memory task using intracranial EEG. The results show robust effects for theta, beta, and high frequency activity during probe presentation requiring a decision. The study also reveals differential involvement of different insula subregions in decision-making and response monitoring.
Article
Psychology, Multidisciplinary
Congchong Li, Wenqing Tian, Yang He, Chaoxian Wang, Xianyang Wang, Xiang Xu, Lifeng Bai, Ting Xue, Yang Liao, Tao Xu, Xufeng Liu, Shengjun Wu
Summary: In this study, the change detection paradigm was used to investigate the working memory of patterned movements and its relationship with the visuospatial sketchpad. The experiments revealed that individuals can store 3-4 patterned movements in working memory, but changes in stimulus type and memory load can affect the processing efficiency. The results also showed that working memory and visual working memory are independent when processing patterned movements, but the working memory of patterned movements is influenced by spatial working memory.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Rong Yao, Jiayue Xue, Pengfei Yang, Qianshan Wang, Peng Gao, Xiaofeng Yang, Hongxia Deng, Shuping Tan, Haifang Li
Summary: This research aims to distinguish brain functional networks of schizophrenia patients from healthy participants during working memory tasks using a method involving microstates. Results show decreased neuronal activity in certain brain regions of schizophrenia patients. The use of microstates significantly reduces the time needed to construct brain functional networks.
Article
Multidisciplinary Sciences
Alejandro Luis Callara, Alberto Greco, Enzo Pasquale Scilingo, Luca Bonfiglio
Summary: The blinking rate is influenced by cognitive tasks and occurs at breakpoints of attention during ecological cognitive tasks. The present study aims to investigate the temporal relationship between blink events and cognitive processing, as well as the effect of stimulus relevance on blink timing and EEG responses. Results show that blink occurrence is influenced by stimuli and blinks following relevant stimuli are apparently delayed due to finalizing a behavioral response, with no effect on the intensity of blink-related EEG response. This evidence suggests that blinks occur at the last step of processing and blink-related EEG responses are all-or-nothing phenomena.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Mikyung Kim, Raly James Custodio, Hyun Jun Lee, Leandro Val Sayson, Darlene Mae Ortiz, Bung-Nyun Kim, Hee Jin Kim, Jae Hoon Cheong
Summary: Several individuals worldwide show cognitive impairment due to various reasons. This study aimed to investigate the pathways potentially involved in cognitive impairment using Per2 transgenic animals. The findings suggest that Per2 expression levels might influence spatial working memory performance via DRD1-PKA-CREB-dependent signaling.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang Yang, Sang-Min Lee, Fumiaki Imamura, Krishne Gowda, Shantu Amin, Richard B. Mailman
Summary: This study compared two different D-1 agonists and found that 2-methyldihydrexidine was more effective in enhancing cognition compared to CY208,243, based on its impact on neural activity and cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Engineering, Biomedical
Rong Yao, Jiayue Xue, Haifang Li, Qianshan Wang, Hongxia Deng, Shuping Tan
Summary: This study used pinning control theory to adjust brain regions interaction in first-episode schizophrenia, revealing abnormal right frontal lobe activity and higher brain network synchronization in schizophrenia patients during a short-term memory task. The synchronization was positively correlated with response time and negatively correlated with response accuracy, with differences in active brain regions between schizophrenia patients and healthy participants.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Behavioral Sciences
Stefanie Suttkus, Andy Schumann, Feliberto de la Cruz, Karl-Juergen Baer
Summary: Findings from the study reveal differential dynamics of ECN and DMN BOLD activations with increasing task demands in both patients with schizophrenia and healthy controls. The study also found increased LC BOLD activation in patients compared to controls, which significantly correlated with key hub regions of the ECN and DMN. The LC-NE system appears to be crucial in modulating neuronal network activity during a 3-back working memory task, contributing significantly to cognitive impairments observed in schizophrenia.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Lara M. Wierenga, Gaelle E. Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A. Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Vince D. Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Vincent P. Clark, Patricia J. Conrod, Annette Conzelmann, Fabrice Crivello, Christopher G. Davey, Erin W. Dickie, Stefan Ehrlich, Dennis Van't Ent, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Paola Fuentes-Claramonte, Eco J. C. de Geus, Annabella Di Giorgio, David C. Glahn, Ian H. Gotlib, Hans J. Grabe, Oliver Gruber, Patricia Gruner, Raquel E. Gur, Ruben C. Gur, Tiril P. Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben J. Harrison, Catharina A. Hartman, Sean N. Hatton, Dirk J. Heslenfeld, Odile A. van den Heuvel, Ian B. Hickie, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony C. James, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Andrew J. Kalnin, Marieke Klein, Laura Koenders, Knut K. Kolskar, Bernd Kramer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina S. Lebedeva, Phil H. Lee, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Brenna C. McDonald, Colm McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Dennis van der Meer, Jose M. Menchon, Jilly Naaijen, Lars Nyberg, Jaap Oosterlaan, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Joaquim Radua, Andreas Reif, Genevieve Richard, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Kang Sim, Andrew Simmons, Jordan W. Smoller, Iris E. Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Philip R. Szeszko, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Julian N. Trollor, Anne Uhlmann, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Volzke, Henrik Walter, Lei Wang, Yang Wang, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather C. Whalley, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Margaret J. Wright, Yuliya N. Yoncheva, Marcus Zanetti, Georg C. Ziegler, Greig de Zubicaray, Paul M. Thompson, Eveline A. Crone, Sophia Frangou, Christian K. Tamnes
Summary: Males exhibit greater variability than females in many traits, which may have implications for understanding sex differences in health and disease. A mega-analysis of brain structure variability based on MRI data of 16,683 healthy individuals spanning nine decades of life reveals significant patterns of greater male than female between-subject variance in subcortical volumes, cortical surface area, and cortical thickness. These sex differences are present in childhood and may be influenced by early life genetic or gene-environment interaction mechanisms. The findings underscore the importance of individual differences within each sex, which may contribute to sex-specific vulnerability to disorders.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Cristopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia De la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis Van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Sophia Frangou
Summary: Age has a significant impact on brain volume, with different regions showing varying trajectories. Basal ganglia volume decreases with age, while lateral ventricles continue to enlarge. These findings provide important insights into the functional significance of age-related morphometric patterns in the brain.
HUMAN BRAIN MAPPING
(2022)
Review
Neurosciences
Giulio Pergola, Nora Penzel, Leonardo Sportelli, Alessandro Bertolino
Summary: The clinically heterogeneous presentation of schizophrenia is compounded by the heterogeneity of risk factors and neurobiological correlates. Genome-wide association studies have uncovered a high number of genetic variants, but their impact on biological pathways remains unclear. Different methodological approaches, such as gene ontologies, regulome approaches, and gene coexpression, have shed light on the translation of genetic risk into the neurobiology of schizophrenia.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Kynon J. M. Benjamin, Qiang Chen, Andrew E. Jaffe, Joshua M. Stolz, Leonardo Collado-Torres, Louise A. Huuki-Myers, Emily E. Burke, Ria Arora, Arthur S. Feltrin, Andre Rocha Barbosa, Eugenia Radulescu, Giulio Pergola, Joo Heon Shin, William S. Ulrich, Amy Deep-Soboslay, Ran Tao, Thomas M. Hyde, Joel E. Kleinman, Jennifer A. Erwin, Daniel R. Weinberger, Apua C. M. Paquola
Summary: In this study, the authors conducted a comprehensive analysis of transcription and genetics in 443 caudate nucleus samples, including 154 individuals with schizophrenia. They identified new genes associated with schizophrenia risk, including the presynaptic DRD2 isoform.
NATURE NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Christian Valt, Tiziana Quarto, Angelantonio Tavella, Fabiola Romanelli, Leonardo Fazio, Giorgio Arcara, Mario Altamura, Giuseppe Barrasso, Antonello Bellomo, Giuseppe Blasi, Flora Brudaglio, Angela Carofiglio, Enrico D'Ambrosio, Flavia Antida Padalino, Antonio Rampino, Alessandro Saponaro, Domenico Semisa, Domenico Suma, Giulio Pergola, Alessandro Bertolino
Summary: This study found that abnormal auditory processing, as reflected by mismatch negativity, is present not only in schizophrenia but also in other psychotic disorders. Additionally, reduced theta inter-trial phase coherence may be associated with the risk for psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Linda A. Antonucci, Giulio Pergola, Antonio Rampino, Paola Rocca, Alessandro Rossi, Mario Amore, Eugenio Aguglia, Antonello Bellomo, Valeria Bianchini, Claudio Brasso, Paola Bucci, Bernardo Carpiniello, Liliana Dell'Osso, Fabio di Fabio, Massimo di Giannantonio, Andrea Fagiolini, Giulia Maria Giordano, Matteo Marcatilli, Carlo Marchesi, Paolo Meneguzzo, Palmiero Monteleone, Maurizio Pompili, Rodolfo Rossi, Alberto Siracusano, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Alessandro Bertolino, Mario Maj
Summary: This study used a machine learning algorithm to classify patients with different levels of resilience in schizophrenia based on multiple variables. The results showed that higher self-esteem, larger social network, and use of adaptive coping strategies were the most frequently chosen variables associated with higher resilience levels. There were significant correlations between algorithm decision scores and patients' cognitive and clinical characteristics.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Constantinos Constantinides, Laura K. M. Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M. Diaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T. Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A. Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Victor Ortiz-Garcia de la Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quide, Paul E. Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarro, Ulrich Schall, Andre Schmidt, Rodney J. Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Therese van Amelsvoort, Javier Vazquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S. Weickert, Thomas Weickert, Paul M. Thompson, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, James H. Cole, Danai Dima, Esther Walton
Summary: Schizophrenia patients show evidence of advanced brain ageing, which is not associated with clinical characteristics.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Giulio Pergola, Madhur Parihar, Leonardo Sportelli, Rahul Bharadwaj, Christopher Borcuk, Eugenia Radulescu, Loredana Bellantuono, Giuseppe Blasi, Qiang Chen, Joel E. Kleinman, Yanhong Wang, Srinidhi Rao Sripathy, Brady J. Maher, Alfonso Monaco, Fabiana Rossi, Joo Heon Shin, Thomas M. Hyde, Alessandro Bertolino, Daniel R. Weinberger
Summary: This study investigated the convergence of putative schizophrenia risk genes in brain coexpression networks and found an early prefrontal involvement in the biology underlying schizophrenia, as well as a dynamic interplay of brain regions related to age. By analyzing multiple data sources, the study identified 28 genes that are consistently associated with schizophrenia risk, with 23 of them being previously unidentified associations. These genes also showed the same relationship with schizophrenia risk genes in induced pluripotent stem cell-derived neurons. The findings suggest that the genetic architecture of schizophrenia is shaped by shifting coexpression patterns across brain regions and time, potentially contributing to its varying clinical presentation.
Article
Multidisciplinary Sciences
Roberta Passiatore, Linda A. Antonucci, Thomas P. DeRamus, Leonardo Fazio, Giuseppe Stolfa, Leonardo Sportelli, Gianluca C. Kikidis, Giuseppe Blasi, Qiang Chen, Juergen Dukart, Aaron L. Goldman, Venkata S. Mattay, Teresa Popolizio, Antonio Rampino, Fabio Sambataro, Pierluigi Selvaggi, William Ulrich, Daniel R. Weinberger, Alessandro Bertolino, Vince D. Calhoun, Giulio Pergola
Summary: Alterations in fMRI-based brain functional network connectivity are associated with the genetic risk and subclinical symptoms of schizophrenia, with age-sensitive risk-related patterns emerging during adolescence and early adulthood. These patterns are also found in adult schizophrenia patients and young individuals with subclinical psychotic symptoms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychiatry
Pierluigi Selvaggi, Leonardo Fazio, Veronica Debora Toro, Armida Mucci, Paola Rocca, Giovanni Martinotti, Giammarco Cascino, Alberto Siracusano, Patrizia Zeppegno, Giulio Pergola, Alessandro Bertolino, Giuseppe Blasi
Summary: This study investigated the effect of anticholinergic burden on brain activity, cognition, and real-world functioning in patients with schizophrenia. The results showed that high anticholinergic burden was associated with reduced brain activity, poorer cognitive performance, and lower real-world functioning.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Genetics & Heredity
Eugenia Radulescu, Qiang Chen, Giulio Pergola, Pasquale Di Carlo, Shizhong Han, Joo Heon Shin, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger
Summary: This study investigated the effects of schizophrenia genetic risk on gene expression in the brain using gene co-expression network analysis. The results showed that preserving or removing schizophrenia genetic risk altered the co-expression modules, and the affected modules were enriched in key biological pathways associated with schizophrenia. These findings reveal the underlying mechanisms of how genetic risk for schizophrenia affects gene expression in the brain.
Article
Automation & Control Systems
Michael McCreesh, Tommaso Menara, Jorge Cortes
Summary: This letter explores the emergence of oscillations in two mesoscale brain network models and provides a structural characterization for the existence of stable node sets. It also identifies sufficient conditions for oscillatory behavior in competitive linear-threshold and threshold-linear dynamics. Simulations are used to illustrate the findings.
IEEE CONTROL SYSTEMS LETTERS
(2023)
Article
Psychiatry
Alessandra Raio, Giulio Pergola, Antonio Rampino, Marianna A. Russo, Enrico D'Ambrosio, Pierluigi Selvaggi, Valerie De Chiara, Mario Altamura, Flora Brudaglio, Alessandro Saponaro, Domenico Semisa, Alessandro Bertolino, Linda Antonucci, Giuseppe Blasi
Summary: This study used machine learning to generate two classifiers based on cognitive and socio-cognitive variables to distinguish patients with bipolar disorder and schizophrenia from healthy controls. The multimodal signatures showed good discrimination between patients and controls in both groups. Furthermore, these signatures could also identify individuals at first episode of psychosis, but not those at clinical high risk.
Meeting Abstract
Neurosciences
Eugenia Radulescu, Qiang Chen, Giulio Pergola, Pasquale Di Carlo, Joo Heon Shin, Thomas Hyde, Joel Kleinman, Daniel Weinberger
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Psychiatry
R. Passiatore, L. Antonucci, T. Deramus, L. Fazio, G. Stolfa, I. Andriola, M. Sangiuliano, M. Altamura, A. Saponaro, F. Brudaglio, A. Carofiglio, T. Popolizio, F. Sambataro, G. Blasi, A. Bertolino, V. Calhoun, G. Pergola
EUROPEAN PSYCHIATRY
(2022)
