SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-09-13
DOI
10.1038/s41467-021-25260-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Small-Cell Carcinoma of the Ovary, Hypercalcemic Type–Genetics, New Treatment Targets, and Current Management Guidelines
- (2020) Marc Tischkowitz et al. CLINICAL CANCER RESEARCH
- CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary
- (2019) Yibo Xue et al. Nature Communications
- SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer
- (2019) Yibo Xue et al. Nature Communications
- Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute
- (2019) Binbin Wang et al. Nature Protocols
- The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting
- (2019) Joshua Pan et al. NATURE GENETICS
- Next-generation characterization of the Cancer Cell Line Encyclopedia
- (2019) Mahmoud Ghandi et al. NATURE
- IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
- (2019) Adam Bartok et al. Nature Communications
- Comprehensive Characterization of Cancer Driver Genes and Mutations
- (2018) Matthew H. Bailey et al. CELL
- Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
- (2018) Yonathan Lissanu Deribe et al. NATURE MEDICINE
- Histone deacetylase inhibitors synergizes with catalytic inhibitors of EZH2 to exhibit anti-tumor activity in small cell carcinoma of the ovary, hypercalcemic type
- (2018) Yemin Wang et al. MOLECULAR CANCER THERAPEUTICS
- Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma
- (2017) Clare E. Weeden et al. MOLECULAR CANCER THERAPEUTICS
- BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
- (2017) Angela Bononi et al. NATURE
- PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
- (2017) Shafi Kuchay et al. NATURE
- BRM Promoter Polymorphisms and Survival of Advanced Non–Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial
- (2016) Geoffrey Liu et al. CLINICAL CANCER RESEARCH
- The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type
- (2016) Leora Witkowski et al. GYNECOLOGIC ONCOLOGY
- Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
- (2016) Joshua D Campbell et al. NATURE GENETICS
- Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria
- (2016) César Cárdenas et al. Cell Reports
- The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
- (2016) Courtney Hodges et al. Cold Spring Harbor Perspectives in Medicine
- HDACs and HDAC Inhibitors in Cancer Development and Therapy
- (2016) Yixuan Li et al. Cold Spring Harbor Perspectives in Medicine
- The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
- (2015) Bhavatarini Vangamudi et al. CANCER RESEARCH
- SMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung Cancer
- (2015) E. H. Bell et al. CLINICAL CANCER RESEARCH
- Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type
- (2015) Anthony N Karnezis et al. JOURNAL OF PATHOLOGY
- Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type
- (2015) Petar Jelinic et al. MODERN PATHOLOGY
- SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas
- (2015) Francois Le Loarer et al. NATURE GENETICS
- miR-106b~25 cluster regulates multidrug resistance in an ABC transporter-independent manner via downregulation of EP300
- (2015) YUNHUI HU et al. ONCOLOGY REPORTS
- Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor
- (2015) Somayyeh Fahiminiya et al. Oncotarget
- Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
- (2015) C. Kadoch et al. Science Advances
- MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs
- (2015) L. Wang et al. Science Advances
- SWI/SNF complexes are required for full activation of the DNA-damage response
- (2015) Stephanie L. Smith-Roe et al. Oncotarget
- At the right distance: ER-mitochondria juxtaposition in cell life and death
- (2014) Deborah Naon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Cisplatin in cancer therapy: Molecular mechanisms of action
- (2014) Shaloam Dasari et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation
- (2014) B. G. Wilson et al. MOLECULAR AND CELLULAR BIOLOGY
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
- (2014) Pilar Ramos et al. NATURE GENETICS
- Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type
- (2014) Leora Witkowski et al. NATURE GENETICS
- Recurrent SMARCA4 mutations in small cell carcinoma of the ovary
- (2014) Petar Jelinic et al. NATURE GENETICS
- ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair
- (2014) S-J Kwon et al. ONCOGENE
- In vitro and in vivotherapeutic approach for a small cell carcinoma of the ovary hypercalcaemic type using a SCCOHT-1 cellular model
- (2014) Anna Otte et al. Orphanet Journal of Rare Diseases
- Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
- (2014) G. R. Hoffman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA
- (2014) Junji Suzuki et al. Nature Communications
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1
- (2013) T. Oike et al. CANCER RESEARCH
- A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non-Small Cell Lung Cancer Patients
- (2013) H. Tang et al. CLINICAL CANCER RESEARCH
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics
- (2013) Lisa F Gamwell et al. Orphanet Journal of Rare Diseases
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- (2013) Balázs Győrffy et al. PLoS One
- Ovarian small cell carcinoma of hypercalcemic type – evidence of germline origin and smarca4 gene inactivation. a pilot study
- (2013) Jolanta Kupryjańczyk et al. POLISH JOURNAL OF PATHOLOGY
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features
- (2012) Daisuke Matsubara et al. CANCER SCIENCE
- MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling
- (2012) Sidong Huang et al. CELL
- Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity
- (2012) Anbarasi Kothandapani et al. EXPERIMENTAL CELL RESEARCH
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Mitochondria as sensors and regulators of calcium signalling
- (2012) Rosario Rizzuto et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
- (2012) Wanjuan Yang et al. NUCLEIC ACIDS RESEARCH
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Jetset: selecting the optimal microarray probe set to represent a gene
- (2011) Qiyuan Li et al. BMC BIOINFORMATICS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
- (2011) Diego De Stefani et al. NATURE
- Integrated genomic analyses of ovarian carcinoma
- (2011) D. Bell et al. NATURE
- An Expanded Palette of Genetically Encoded Ca2+ Indicators
- (2011) Y. Zhao et al. SCIENCE
- Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
- (2010) César Cárdenas et al. CELL
- Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors
- (2010) Salvador Rodriguez-Nieto et al. HUMAN MUTATION
- Prognostic and Predictive Gene Signature for Adjuvant Chemotherapy in Resected Non–Small-Cell Lung Cancer
- (2010) Chang-Qi Zhu et al. JOURNAL OF CLINICAL ONCOLOGY
- PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release
- (2010) C. Giorgi et al. SCIENCE
- JNJ-26481585, a Novel "Second-Generation" Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
- (2009) J. Arts et al. CLINICAL CANCER RESEARCH
- The SWI/SNF complex and cancer
- (2009) D Reisman et al. ONCOGENE
- Mammalian SWI/SNF chromatin remodeling complexes are required to prevent apoptosis after DNA damage
- (2008) Ji-Hye Park et al. DNA REPAIR
- Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
- (2008) Kerby Shedden et al. NATURE MEDICINE
- Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
- (2008) P Pinton et al. ONCOGENE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More