Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle

Life-threatening cardiac arrhythmias in congenital central hypoventilation syndrome

(2020) Eric Laifman et al.   EUROPEAN JOURNAL OF PEDIATRICS

TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1

(2020) Jie Su et al.   NATURE

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(2020) Naresh Doni Jayavelu et al.   Nature Communications

Pervasive and CpG-dependent promoter-like characteristics of transcribed enhancers

(2020) Robin Steinhaus et al.   NUCLEIC ACIDS RESEARCH

Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes

(2020) Oliver A. Kent et al.   Nature Communications

Draft Genome of the Common Snapping Turtle, Chelydra serpentina, a Model for Phenotypic Plasticity in Reptiles

(2020) Debojyoti Das et al.   G3-Genes Genomes Genetics

Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension

(2019) Aurélie Hautefort et al.   CIRCULATION

Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury

(2019) Amanda Bundgaard et al.   Scientific Reports

Glucocorticoids and programming of the microenvironment in heart

(2019) Rui Song et al.   JOURNAL OF ENDOCRINOLOGY

Roles and regulation of histone methylation in animal development

(2019) Ashwini Jambhekar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Embryonic developmental oxygen preconditions cardiovascular function response to acute hypoxic exposure and maximal β-adrenergic stimulation of anesthetized juvenile American alligators (Alligator mississippiensis)

(2019) Brandt Smith et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

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(2019) Éléa Héberlé et al.   Essays in Biochemistry

Glucocorticoid Maturation of Fetal Cardiovascular Function

(2019) Juanita K. Jellyman et al.   TRENDS IN MOLECULAR MEDICINE

Prenatal hypoxia-induced epigenomic and transcriptomic reprogramming in rat fetal and adult offspring hearts

(2019) Xin Chen et al.   Scientific Data

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex IS-nitrosation

(2018) Amanda Bundgaard et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

(2018) Dafni Anastasiadi et al.   Epigenetics & Chromatin

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(2018) D. V. Klopfenstein et al.   Scientific Reports

MeDEStrand: an improved method to infer genome-wide absolute methylation levels from DNA enrichment data

(2018) Jingting Xu et al.   BMC BIOINFORMATICS

Foetal hypoxia impacts methylome and transcriptome in developmental programming of heart disease

(2018) Lei Huang et al.   CARDIOVASCULAR RESEARCH

Orphan CpG islands define a novel class of highly active enhancers

(2017) Joshua S. K. Bell et al.   Epigenetics

MeDIP-seq and nCpG analyses illuminate sexually dimorphic methylation of gonadal development genes with high historic methylation in turtle hatchlings with temperature-dependent sex determination

(2017) Srihari Radhakrishnan et al.   Epigenetics & Chromatin

Gain-of-function mutations inSMAD4cause a distinctive repertoire of cardiovascular phenotypes in patients with Myhre syndrome

(2016) Angela E. Lin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Phenotypic plasticity in the common snapping turtle (Chelydra serpentina): long-term physiological effects of chronic hypoxia during embryonic development

(2016) Oliver H. Wearing et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Periods of cardiovascular susceptibility to hypoxia in embryonic american alligators (Alligator mississippiensis)

(2016) Kevin B. Tate et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Transcription factors as readers and effectors of DNA methylation

(2016) Heng Zhu et al.   NATURE REVIEWS GENETICS

Epigenetics in preimplantation mammalian development

(2016) Sebastian Canovas et al.   THERIOGENOLOGY

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

(2015) Borbala Mifsud et al.   NATURE GENETICS

Critical Windows of Cardiovascular Susceptibility to Developmental Hypoxia in Common Snapping Turtle (Chelydra serpentina) Embryos

(2015) Kevin B. Tate et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

On the presence and role of human gene-body DNA methylation

(2015) Daudi Jjingo et al.   Oncotarget

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Programming of the Hypothalamic-Pituitary-Adrenal Axis by Neonatal Intermittent Hypoxia: Effects on Adult Male ACTH and Corticosterone Responses Are Stress Specific

(2014) Kathan Chintamaneni et al.   ENDOCRINOLOGY

Adjustments in cholinergic, adrenergic and purinergic control of cardiovascular function in snapping turtle embryos (Chelydra serpentina) incubated in chronic hypoxia

(2014) John Eme et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

The biology of developmental plasticity and the Predictive Adaptive Response hypothesis

(2014) Patrick Bateson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Early Life Nutrition, Epigenetics and Programming of Later Life Disease

(2014) Mark Vickers   Nutrients

Plasticity of cardiovascular function in snapping turtle embryos (Chelydra serpentina): chronic hypoxia alters autonomic regulation and gene expression

(2013) John Eme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype

(2013) Chris J. Watson et al.   HUMAN MOLECULAR GENETICS

Chromatin modifiers and remodellers: regulators of cellular differentiation

(2013) Taiping Chen et al.   NATURE REVIEWS GENETICS

TGF-β-Dependent Active Demethylation and Expression of the p15ink4b Tumor Suppressor Are Impaired by the ZNF217/CoREST Complex

(2012) Gobi Thillainadesan et al.   MOLECULAR CELL

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

Epigenetics and the environment: emerging patterns and implications

(2012) Robert Feil et al.   NATURE REVIEWS GENETICS

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

(2012) Altuna Akalin et al.   GENOME BIOLOGY

Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E–Deficient Mice

(2011) Kimio Satoh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

Epigenetic Modifications

(2011) Diane E. Handy et al.   CIRCULATION

Hypoxic alligator embryos: Chronic hypoxia, catecholamine levels and autonomic responses of in ovo alligators

(2011) John Eme et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Physiological responses to acute changes in temperature and oxygenation in bird and reptile embryos

(2011) Marina V. Nechaeva   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Physiology of hibernation under the ice by turtles and frogs

(2010) Donald C. Jackson et al.   Journal of Experimental Zoology Part A-Ecological Genetics and Physiology

Conservation and divergence of methylation patterning in plants and animals

(2010) S. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation

(2010) A. Zemach et al.   SCIENCE

Correlation of cardiac performance with cellular energetic components in the oxygen-deprived turtle heart

(2009) Jonathan A. W. Stecyk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

CpG islands - ‘A rough guide’

(2009) Robert S. Illingworth et al.   FEBS LETTERS

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Cardiac survival in anoxia-tolerant vertebrates: An electrophysiological perspective

(2008) Jonathan A.W. Stecyk et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

DNA Methylation and Structural and Functional Bimodality of Vertebrate Promoters

(2008) N. Elango et al.   MOLECULAR BIOLOGY AND EVOLUTION