Article
Pharmacology & Pharmacy
Yan Chen, Baixing Li, Yue Xu, Tangjun Zhou, Changqing Zhao, Jie Zhao
Summary: Inhibition of endoplasmic reticulum stress by Sal003 protects against apoptosis and extracellular matrix degradation, offering a potential treatment for intervertebral disc degeneration.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lei Li, Jiale He, Guangzhi Zhang, Haiwei Chen, Zhangbin Luo, Bo Deng, Yuan Zhou, Xuewen Kang
Summary: Intervertebral disc degeneration is a common musculoskeletal degenerative disease characterized by low back pain. The pathogenesis and pathological process of this disease are still unclear, and current treatments only provide symptom relief. Recent research has shown that caspases play a significant role in intervertebral disc degeneration and may serve as potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Xiuyuan Chen, Yucheng Ji, Fan Feng, Zude Liu, Lie Qian, Hongxing Shen, Lifeng Lao
Summary: The intervertebral disc (IVD) is essential for spinal flexibility. The protein CLEC3A supports the differentiation of chondrocytes and maintenance of NP cells, crucial for disc health. Mechanistic analysis reveals that CLEC3A stimulates the PI3K-AKT pathway to accelerate cell proliferation and NP cell regeneration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Weikang Zhang, Yuhang Gong, Xiaohang Zheng, Jianxin Qiu, Ting Jiang, Lihua Chen, Fangying Lu, Xinhui Wu, Fengmin Cheng, Zhenghua Hong
Summary: PDGF-BB promotes extracellular matrix synthesis of NPCs and inhibits pyroptosis, participating in the inhibition of IDD through regulating the MAPK signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Shengxu Zhu, Junlin Wang, Moran Suo, Huagui Huang, Xin Liu, Jinzuo Wang, Zhonghai Li
Summary: Low back pain caused by intervertebral disc degeneration is a global public health problem that significantly impacts patients' quality of life and imposes a huge economic burden on individuals and society. Current treatments cannot reverse or delay the progression of intervertebral disc degeneration. The emergence of extracellular vesicles (EVs) as a biologic therapy offers new hope for the treatment of intervertebral disc degeneration.
AGEING RESEARCH REVIEWS
(2023)
Article
Oncology
GuangDuo Zhu, XiaoWei Yang, WeiWei Zhou, Xu Lian, YingJie Hao
Summary: Excessive apoptosis of nucleus pulposus (NP) cells is the key factor in intervertebral disc degeneration (IVDD) progression. Pleomorphic adenoma gene like-2 (PLAGL2) has been found to play a crucial role in cell apoptosis. In this study, the researchers established mouse IVDD models and investigated the effect of PLAGL2 on NP cells' viability, apoptosis, and mitochondria function. They found that PLAGL2 was upregulated in IVDD disc tissues and stimulated NP cells. Knockdown of PLAGL2 inhibited apoptosis and mitochondria damage in NP cells. Furthermore, PLAGL2 was found to transcriptionally activate RASSF5, a downstream apoptosis-related factor. Overall, this study suggests that PLAGL2 induces apoptosis in NP cells and exacerbates IVDD progression, providing a potential therapeutic target for IVDD treatment.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Hai-Jun Zhang, Hai-Yang Liao, Deng-Yan Bai, Zhi-Qiang Wang, Xing-Wen Xie
Summary: Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease that is considered the main cause of low back pain. It is mainly caused by aging, trauma, genetic susceptibility, and other factors. Current treatment focuses on alleviating symptoms rather than targeting pathological changes in the intervertebral discs.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Gaofeng Zhang, Yuanmei Liao, Hanshi Yang, Jian Tao, Lin Ma, Xiaohua Zuo
Summary: Irigenin, an isoflavonoid from Belamcanda chinensis, shows potential in reducing intervertebral disc degeneration (IDD) by inhibiting apoptosis and extracellular matrix degradation through decreasing the expression of caspase-3 and MMPs in TNF-alpha-stimulated nucleus pulposus cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Zuo-long Wu, Ya-jun Chen, Guang-zhi Zhang, Qi-qi Xie, Ke-ping Wang, Xin Yang, Tai-Cong Liu, Zhi-qiang Wang, Guang-hai Zhao, Hai-Hong Zhang
Summary: This study found the significance of SKI in intervertebral disc degeneration (IDD) and demonstrated that silencing SKI can reduce NP cell apoptosis and extracellular matrix degradation, thus protecting against IDD. These findings suggest that SKI may be an effective target for IDD treatment.
Article
Biochemistry & Molecular Biology
Daxue Zhu, Zhaoheng Wang, Guangzhi Zhang, Congwen Ma, Xiaoming Qiu, Yidian Wang, Mingqiang Liu, Xudong Guo, Haiwei Chen, Qiang Deng, Xuewen Kang
Summary: This study investigates the role of periostin (POSTN) in intervertebral disc degeneration (IVDD) and its relationship with beta-catenin. The expression of beta-catenin, POSTN, and cleaved-caspase-3 (C-caspase3) was found to be significantly higher in severely degenerated IVDs. Treatment with recombinant periostin (rPOSTN) promoted NPCs apoptosis in a time- and dose-dependent manner through the activation of the Wnt/beta-catenin pathway. Inhibition of POSTN reduced apoptosis, which could be restored by re-addition of rPOSTN. Finally, POSTN inhibition ameliorated puncture-induced IVDD in vivo. Overall, this study demonstrates that POSTN promotes NPCs apoptosis and aggravates degeneration by activating the Wnt/beta-catenin pathway.
Article
Orthopedics
Q. Guo, D. Zhu, Y. Wang, Z. Miao, Z. Chen, Z. Lin, J. Lin, C. Huang, L. Pan, L. Wang, S. Zeng, J. Wang, X. Zheng, Y. Lin, X. Zhang, Y. Wu
Summary: STING upregulation in degenerated NP tissues promotes ECM degradation, apoptosis, and senescence, contributing to IVDD progression. Mechanistically, STING activates IRF3 pathway to exert its effects on IVDD development.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Orthopedics
G. Chao-yang, C. Peng, Z. Hai-hong
Summary: This article summarizes the role of the NLRP3 inflammasome in the pathogenesis of IVDD and its application in treatment.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biotechnology & Applied Microbiology
Andrea Vernengo, Helen Bumann, Nadine Kluser, Astrid Soubrier, Amra Secerovic, Jan Gewiess, Jan Ulrich Jansen, Cornelia Neidlinger-Wilke, Hans-Joachim Wilke, Sibylle Grad
Summary: Chemonucleolysis is an established method for creating organ culture models of intervertebral disc degeneration. The effects of different enzymes used in chemonucleolysis need to be compared to gain a better understanding of how these models mimic human degeneration. The study induced chemonucleolysis in bovine IVDs and evaluated the cellular, biochemical, and histological properties after 7 days.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Medicine, Research & Experimental
Chao-yang Gong, Hai-hong Zhang
Summary: Autophagy plays a dual role in intervertebral disc degeneration, as inducing autophagy can slow down the process while excessive autophagy activation-mediated apoptosis may accelerate degeneration.