Article
Cardiac & Cardiovascular Systems
Nihar Masurkar, Marion Bouvet, Damien Logeart, Charlene Jouve, Fatou Drame, Olivier Claude, Maguelonne Roux, Clement Delacroix, Damien Bergerot, Jean-Jacques Mercadier, Marc Sirol, Barnabas Gellen, Marine Livrozet, Antoine Fayol, Estelle Robidel, David-Alexandre Tregouet, Giovanna Marazzi, David Sassoon, Mariana Valente, Jean-Sebastien Hulot
Summary: After myocardial infarction, the secretion of GDF3 by cardiac stromal cells promotes fibroblast proliferation, leading to adverse fibrotic remodeling.
Review
Hematology
Xiaolei Liu, Kui Cui, Hao Wu, Kathryn S. Li, Qianman Peng, Donghai Wang, Douglas B. Cowan, J. Brandon Dixon, R. Sathish Srinivasan, Diane R. Bielenberg, Kaifu Chen, Da-Zhi Wang, Yabing Chen, Hong Chen
Summary: Lymphatic vessels are important in maintaining tissue fluid homeostasis, immune cell trafficking, and dietary lipid transport. Promoting lymphatic growth and function can reduce inflammation and alleviate metabolic and cardiovascular diseases. Recent studies have shown the potential benefits of lymphangiogenesis in treating these diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Cagla Eren Cimenci, Nick J. R. Blackburn, Veronika Sedlakova, Justina Pupkaite, Marcelo Munoz, Benjamin H. Rotstein, David A. Spiegel, Emilio I. Alarcon, Erik J. Suuronen
Summary: The study demonstrates that fisetin-collagen hydrogel therapy can reduce the negative effects of MG post-MI by increasing glyoxalase-1 levels, decreasing MG-AGE accumulation, and reducing oxidative stress, leading to improved cardiac function. Additionally, the therapy promotes neovascularization, increases pro-healing macrophages, and decreases pro-inflammatory macrophages in the infarct area.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Cell Biology
Qiong Li, Huifang Hou, Meng Li, Xia Yu, Hongbo Zuo, Jianhui Gao, Min Zhang, Zongjin Li, Zhikun Guo
Summary: The research demonstrates the effective role of CD73(+) AD-MSCs in treating myocardial infarction by promoting angiogenesis for accelerating cardiac recovery. This subgroup shows differences in the expression of factors like VEGF compared to other subgroups, suggesting its potential superiority in myocardial repair.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Arwa Kohela, Sebastiaan J. van Kampen, Tara Moens, Martijn Wehrens, Bas Molenaar, Cornelis J. Boogerd, Jantine Monshouwer-Kloots, Ilaria Perini, Marie Jose Goumans, Anke M. Smits, J. Peter van Tintelen, Eva van Rooij
Summary: This study used hiPSC-derived cardiac cultures and explanted human hearts to investigate the role of epicardium in fibro-fatty remodeling in ACM, revealing that TFAP2A-mediated epicardial EMT is a key mechanism underlying this process.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Ferhat Eyyupkoca, Karabekir Ercan, Emrullah Kiziltunc, Ilgin Burcu Ugurlu, Ajar Kocak, Nilnur Eyerci
Summary: Increasing evidence suggests that miRNA plays an important role in myocardial healing and ventricular remodeling after acute myocardial infarction (AMI). A study found that there are 8 miRNAs associated with adverse left ventricular remodeling in ST-elevated MI patients. Among them, 3 miRNAs show significant differences during the follow-up period, while the rest show differences during the acute phase of AMI. Further mechanistic studies are needed to understand the complex remodeling process after AMI.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruifeng Guo, Xiao Wang, Qian Guo, Yan Yan, Wei Gong, Wen Zheng, Guanqi Zhao, Hui Wang, Lei Xu, Shaoping Nie
Summary: This study aimed to evaluate age-related differences in ventricular remodeling after primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI). The results showed that young patients are more likely to have adverse remodeling and less likely to develop reverse remodeling after PPCI compared with old patients, highlighting the importance of paying equal or more attention to young patients with STEMI.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Icia Santos-Zas, Jeremie Lemarie, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bize, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, Jose Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sebastien Silvestre, Hafid Ait-Oufella
Summary: This study reveals the detrimental role of CD8(+) T lymphocytes following acute myocardial infarction, showing that they release Granzyme B in the ischemic heart tissue leading to cardiomyocyte apoptosis, adverse ventricular remodeling, and deterioration of myocardial function. Depletion of CD8(+) T lymphocytes leads to reduced apoptosis, inhibited inflammatory response, limited myocardial injury, and improved heart function. Elevated circulating levels of GRANZYME B in AMI patients may predict increased risk of death at 1-year follow-up. Targeting pathogenic CD8(+) T lymphocytes could be a potential therapeutic strategy in the setting of acute myocardial infarction.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Vicente Bodi, Jose Gavara, Maria P. Lopez-Lereu, Jose V. Monmeneu, Elena de Dios, Nerea Perez-Sole, Clara Bonanad, Victor Marcos-Garces, Joaquim Canoves, Gema Minana, Julio Nunez, David Moratal, Francisco J. Chorro, Jose F. Rodriguez-Palomares, Andrea Freixa, Roger Borras, Jose T. Ortiz-Perez, Cesar Rios-Navarro
Summary: This study used cardiac magnetic resonance (CMR) to investigate the impact of persistent microvascular obstruction (MVO) on adverse left ventricular remodeling (ALVR) after reperfused ST-segment elevation myocardial infarction (STEMI). The results showed that 6% of STEMI patients exhibited persistent MVO, which was associated with detrimental effects on left ventricular remodeling. Further research on microvascular injury repair is needed based on these findings.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ke Shi, Min Ma, Meng-Xi Yang, Chun-Chao Xia, Wan-Lin Peng, Yong He, Zhen-Lin Li, Ying-Kun Guo, Zhi-Gang Yang
Summary: This study found that acute oxygenation signal intensity in reperfused acute ST-segment elevation myocardial infarction (STEMI) patients showed a stepwise rise among different LV segments compared with healthy myocardium. Acute oxygenation signal intensity was associated with early myocardial injury and predicted adverse LV segment remodeling after STEMI.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fabian Islas, Eva Gutierrez, Victoria Cachofeiro, Ernesto Martinez-Martinez, Gema Marin, Carmen Olmos, Irene Carrion, Sandra Gil, Patricia Mahia, Miguel Angel Cobos, Alberto de Agustin, Maria Luaces
Summary: In patients with acute myocardial infarction (AMI), epicardial adipose tissue (EAT) thickness greater than 4mm is associated with morpho-functional changes in the left ventricle, larger infarct size, and chronic inflammatory processes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Kyoko Komai, Nicholas K. Kawasaki, Jason K. Higa, Takashi Matsui
Summary: Ferroptosis is an iron-dependent form of regulated cell death characterized by dysfunction of the GPX4 antioxidant system. Inhibiting ferroptosis restores cardiac function and provides protection against I/R injury.
Article
Pharmacology & Pharmacy
Baoli Zhang, Peng Yu, Enyong Su, Jianguo Jia, Chunyu Zhang, Shiyao Xie, Zhenhui Huang, Ying Dong, Jinguo Ding, Yunzeng Zou, Hong Jiang, Junbo Ge
Summary: Sodium tanshinone IIA sulfonate (STS) can improve pathological cardiac remodeling after myocardial infarction (MI) through reducing myocardial necrosis, modulating inflammation, and increasing angiogenesis.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Cardiac & Cardiovascular Systems
Wanrong Man, Xinglong Song, Zhenyu Xiong, Jing Gu, Jie Lin, Xiaoming Gu, Duan Yu, Congye Li, Mengyuan Jiang, Xuebin Zhang, Zhi Yang, Yang Cao, Yan Zhang, Xiaofei Shu, Dexi Wu, Haichang Wang, Gang Ji, Dongdong Sun
Summary: This study reveals the important role of Adipsin in cardiovascular diseases, demonstrating its ability to protect cardiomyocytes against ferroptosis and maintain iron homeostasis. The efficient delivery of Adipsin to the heart through exosomes suggests a promising therapeutic strategy to prevent adverse cardiac remodeling following ischemic heart injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Ling Yu, Yubin Liang, Minzhou Zhang, Phillip C. Yang, Aleksander Hinek, Shuai Mao
Summary: Emerging studies reveal the important roles of extracellular vesicles (EVs) and their inner circular RNAs (circRNAs) in gene regulation and cardiovascular repair. However, the understanding of EV-derived circRNAs in cardiac remodeling after myocardial infarction (MI) is limited. Here, it is demonstrated that circCEBPZOS is downregulated in serum EVs of patients with adverse cardiac remodeling after MI. In vitro experiments show that circCEBPZOS promotes angiogenesis. In vivo overexpression of circCEBPZOS in mice attenuates MI-induced left ventricular dysfunction and enhances revascularization.
COMMUNICATIONS BIOLOGY
(2023)
Article
Statistics & Probability
Jingfei Zhang, Yi Li
Summary: This article proposes a Gaussian graphical regression model to link graph structures to external covariates. In co-expression QTL studies, the method can determine how genetic variants and clinical conditions modulate network structures, and recover gene networks. The utility and efficacy of the method is demonstrated through simulation studies and an application example.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Food Science & Technology
Jingjing Zhang, Shijin Zhang, Linqing Wang, Wenqiang Tan, Qing Li, Zhanyong Guo
Summary: In this study, four novel derivatives of chitosan oligosaccharide (COS) were synthesized by grafting pyridine-4-aldehyde Schiff bases onto chloracetyl chitosan oligosaccharide (CACS). The structural characterization was conducted using FTIR and NMR. The COS derivatives showed better antioxidant and antibacterial activities compared to COS and CACS, which may be attributed to the positive charge of these derivatives. Among them, derivative BPCACS with the highest degree of substitution exhibited the best bioactivity with high scavenging rate and inhibition diameter.
Article
Chemistry, Physical
Ye Xu, Fang Jin, Guiying Wu, Tao Wang, Jingchao Zhang, Yanjun Chen
Summary: The borosilicate zeolite ERB-1 was modified by loading titanium and changing its polarity to improve its catalytic activity in aqueous solutions. The modified Ti-ERB-1 showed significantly improved catalytic activity in the presence of H2O2 oxidant.
Article
Environmental Sciences
Xuening Lin, Yuhuan Cui, Shuang Hao, Hong Hong, Man Zhang, Jingdong Zhang, Ruonan Li, Mengyu Liu
Summary: Urban expansion has exacerbated the heat-island effect, but urban lakes can significantly alleviate this effect. The temperature of the lake is the main factor influencing the cooling efficiency, while the lake area and the distance to the city center are secondary factors. Lakes around the urban area have limited ability to absorb the high surface temperature caused by the heat-island effect, resulting in lower cooling efficiency compared to lakes in the main urban area.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Meimei Li, Boliao Li, Qi Yang, Yanying Li, Junxiang Wu, Xiangli Xu
Summary: In this study, we identified 50 neuropeptides including neuropeptide Y (NPY) of Mythimna separata using transcriptome sequencing. The spatial and temporal expression profile of NPY indicated its important role in feeding regulation and energy metabolism. Knockdown of NPY significantly inhibited food uptake and body weight, delayed developmental duration, and altered energy storage in M. separata larvae.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Yuzhao Ouyang, Decai Zhu, Chengjun Zhu, Yingbo Zhang, Jiamei Liu, Xin Jia, Jie Yu, Xinfang Li, Min Yang, Xiaowei Gao
Summary: This study reports a new Ruddlesden-Popper (R-P) structure oxide, which is widely used as the electrode material in low temperature solid oxide fuel cells (LT-SOFCs) due to its high catalytic activity and excellent oxygen transport performance. However, there are few reports on its application as the electrolyte material in LT-SOFCs. The researchers prepared a P-N heterostructure by using R-P P-type semiconductor Sm1.2Sr0.8Ni0.6Fe0.4O4+5 (SSNF) oxide material as the electrolyte and N-type semiconductor Sm0.075Nd0.075Ce0.85O2-5 (SNDC) oxide material as the cathode. The 5SSNF-5SNDC composite electrolyte exhibited a high ionic conductivity of 0.201 S.cm-1 and a remarkable fuel cell power density of 1056 mW.cm-2 at 550℃. The results indicate that P-N heterojunctions constructed from oxide materials with highly catalytically active R-P structures exhibit excellent electrolyte performance. This work provides a new perspective for developing advanced electrolytes of LT-SOFCs.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Chemistry, Physical
Jian Zhao, Chao Li, Xiaodong Fan, Hao Liu, Ziqi Liu, Jingchao Zhang, Zhizhong Sun, Wenyi Chu
Summary: A series of Bronsted-Lewis acidic tetraimidazolyl ionic liquids ([TeimILs]) were designed and synthesized, and [Teim-PS] [AlCl4]4 showed good catalytic performance in the conversion of glucose to 5-HMF with a biphasic system. The catalyst could be reused multiple times without significant decrease in yield. The biphasic system facilitated catalyst recycling and separation of 5-HMF. The catalytic system also exhibited applicability to the degradation of other carbohydrate compounds, and had a low activation energy of 49.98 KJ/mol. This work provides a new solution for the efficient and green conversion of glucose to 5-HMF.
APPLIED CATALYSIS A-GENERAL
(2023)
Article
Thermodynamics
Ning Qian, Fan Jiang, Marco Marengo, Jiajia Chen, Yucan Fu, Jingzhou Zhang, Jiuhua Xu
Summary: This study investigates the start-up behavior of oscillating heat pipes (OHP) under axial-rotation and highlights the importance of start-up speed on grinding efficiency and quality. It is found that OHP filled with acetone has the shortest start-up time, and the cold air pressure and centrifugal acceleration significantly affect the start-up time.
APPLIED THERMAL ENGINEERING
(2023)
Article
Computer Science, Hardware & Architecture
Jingjing Zhang, Yongjie Ye, Weigang Wu, Xiapu Luo
Summary: Payment channels are a promising solution to improve scalability in decentralized ledgers by enabling micropayments without involving the blockchain. This paper introduces a novel off-chain system called channel hub, which shortens the routing path for payment networks. Compared to existing payment hubs, channel hub is more efficient and lightweight as it connects already constructed payment channels within the network. The proposed protocol, Boros, ensures secure off-chain cross-channel transfers and is demonstrated with a proof-of-concept prototype.
IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING
(2023)
Review
Materials Science, Multidisciplinary
Jingjing Zhang, Bing Zhang, Xiubo Xie, Cui Ni, Chuanxin Hou, Xueqin Sun, Xiaoyang Yang, Yuping Zhang, Hideo Kimura, Wei Du
Summary: This paper reviews recent advances in the nanoconfinement of Mg-based hydrogen storage materials by loading Mg particles on different supporting materials and discusses the prospects for designing high-performance Mg-based materials using nanoconfinement.
INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS
(2023)
Article
Optics
Yanpeng Cao, Rui Liang, Wenbin Zhu, Bowen Zhao, Haotian Chen, Lingfeng Shen, Jiangxin Yang, Yanlong Cao, Jian Chen, Xin Li
Summary: This paper presents a complete framework for rendering and processing dynamic-excitation-based steady-state NLOS images. A virtual rendering pipeline is constructed to generate large-scale rendered images, and a physical hardware setup is built to acquire real-captured images. An end-to-end multi-branch CNN is proposed to reconstruct specular-reflected images of hidden objects. The effectiveness of the method is validated through qualitative and quantitative experiments.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Zewei He, Du Chen, Yanpeng Cao, Jiangxin Yang, Yanlong Cao, Xin Li, Siliang Tang, Yueting Zhuang, Zhe-ming Lu
Summary: This study proposes an efficient model, SISR-PF-OA, for single image super-resolution, achieving more accurate and faster image restoration by improving feature extraction and fusion techniques. It includes a novel Orientation-Aware feature extraction/selection Module (OAM) and an effective fusion architecture to progressively integrate multi-scale features extracted in different convolutional stages.
PATTERN RECOGNITION
(2023)
Review
Chemistry, Physical
Yingbo Zhang, Junan Pan, Gu Gong, Renxuan Song, Ye Yuan, Mengzhu Li, Weifeng Hu, Pengcheng Fan, Lexing Yuan, Longlu Wang
Summary: This article reviews recent advances in the in situ surface reconstitution of catalysts for hydrogen evolution, focusing on the relationship between active site structure evolution and the self-optimization of HER activity. Various types of reconstruction are discussed, and future perspectives and outlooks are provided.
Article
Chemistry, Multidisciplinary
Yi Ren, Jingjing Zhang, Xinxin Gao, Xin Zheng, Le Peng Zhang, Tie Jun Cui
Summary: In this paper, a general method for impedance matching in the design of miniaturized spoof plasmonic antennas based on SSPPs is proposed. A prototype of a planar spoof plasmonic dipole antenna is simulated, fabricated, and measured to verify the effectiveness of the method. The results show significant improvements compared to traditional dipole antennas.
Article
Computer Science, Hardware & Architecture
Feng Zhu, Jingjing Zhang, Xin Wang
Summary: This paper proposes a novel worker selection strategy called AgeSel, which utilizes the ages of workers to balance their participation frequencies, to improve communication efficiency and speed up the training process.
JOURNAL OF SUPERCOMPUTING
(2023)