Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28

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ARCHES: A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer

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Integrative transcriptome analysis identifies genes and pathways associated with enzalutamide resistance of prostate cancer

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Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

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Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

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Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer

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Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth

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Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment

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Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

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An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)

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Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor-Targeted Therapy

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(2012) Catherine S. Grasso et al.   NATURE

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cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

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The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

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(2010) Dwayne G. Stupack   CANCER LETTERS

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Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

(2009) S. Barbero et al.   CANCER RESEARCH

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

(2009) Yu Chen et al.   LANCET ONCOLOGY

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Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE

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NF-κB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation

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