Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

(2021) Shin-ichiro Hattori et al.   Nature Communications

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

(2021) Sebastian Günther et al.   SCIENCE

Novel Insights Into Immune Systems of Bats

(2020) Arinjay Banerjee et al.   Frontiers in Immunology

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

(2020) Javier A. Jaimes et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection

(2020) Shin-ichiro Hattori et al.   mBio

Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors

(2020) Sk. Abdul Amin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potential SARS-CoV-2 main protease inhibitors

(2020) Riddhidev Banerjee et al.   DRUG DISCOVERY TODAY

Protease inhibitors targeting the main protease and papain-like protease of coronaviruses

(2020) Clemente Capasso et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19

(2020) Wen Cui et al.   Frontiers in Molecular Biosciences

High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress

(2019) Yok Teng Chionh et al.   CELL STRESS & CHAPERONES

Migratory flight imposes oxidative stress in bats

(2018) David Costantini et al.   Current Zoology

Migratory flight imposes oxidative stress in bats

(2018) David Costantini et al.   Current Zoology

Evaluation of Methods for the Calculation of the pKa of Cysteine Residues in Proteins

(2016) Ernest Awoonor-Williams et al.   Journal of Chemical Theory and Computation

Posttranslational Modification of Cysteine in Redox Signaling and Oxidative Stress: Focus on S-Glutathionylation

(2011) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation and maturation of SARS-CoV main protease

(2011) Bin Xia et al.   Protein & Cell

Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage

(2010) Raquel Requejo et al.   FEBS Journal

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Initial Step in Human Immunodeficiency Virus Type 1 GagProPol Processing Can Be Regulated by Reversible Oxidation

(2010) Sarah I. Daniels et al.   PLoS One

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

(2010) Anton Soucy-Faulkner et al.   PLoS Pathogens

Analysis and characterization of dimerization inhibition of a multi-drug-resistant Human Immunodeficiency Virus Type 1 protease using a novel size-exclusion chromatographic approach

(2009) David A. Davis et al.   BIOCHEMICAL JOURNAL

Reactive Oxygen Species-Induced Stimulation of 5'AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection

(2009) R. R. Lamberts et al.   CIRCULATION

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of caspase-3 activity and activation by protein glutathionylation

(2008) Zhishan Huang et al.   BIOCHEMICAL PHARMACOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Methionine in proteins defends against oxidative stress

(2008) Shen Luo et al.   FASEB JOURNAL

Mechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease

(2008) J. Shi et al.   JOURNAL OF VIROLOGY