Article
Urology & Nephrology
Freek P. W. de Rooij, Femke R. M. Peters, Brechje L. Ronkes, Wouter B. van Der Sluis, Muhammed Al-Tamimi, R. Jeroen A. van Moorselaar, Mark-Bram Bouman, Garry L. S. Pigot
Summary: A retrospective cohort study was conducted on 72 transgender men who underwent surgical correction of urethral strictures between January 2013 and March 2020. Most patients were able to void while standing at the last follow-up, with improving success rates over time.
Article
Medicine, General & Internal
Christina A. Muzny, Olivia T. Van Gerwen, Julia A. Schroeder, Emma Sophia Kay-Duncan, Krishmita Siwakoti, Kristal J. Aaron, Isaac C. Eastlund, Keonte J. Graves, Jacob H. Elnaggar, Ashutosh Tamhane, Dustin Long, Nicholas Van Wagoner, Evelyn Toh, Christopher M. Taylor
Summary: This prospective study aims to investigate changes in the vaginal microbiota over time in transgender men who initiate testosterone therapy. The study will also identify factors associated with bacterial vaginosis and will be disseminated through conferences and journals as well as shared with gender health clinics and community organizations.
Article
Urology & Nephrology
Augustus Parker, Hilliard Brydges, Gaines Blasdel, Rachel Bluebond-Langner, Lee C. Zhao
Summary: This study investigated the use of AlloDerm in canal deepening surgeries. The results showed that AlloDerm is a safe and effective option for revision surgeries and does not require a secondary donor site.
Article
Urology & Nephrology
Freek P. W. de Rooij, Marco Falcone, Mieke Waterschoot, Giuseppe Pizzuto, Mark-Bram Bouman, Paolo Gontero, Nicolaas Lumen, Garry L. S. Pigot
Summary: This study analyzed the surgical outcomes after treatment of urethral strictures and urethral fistulas following metoidioplasty in transmen. Open surgical techniques showed better long-term outcomes in managing urethral strictures, while a colpectomy was found to be beneficial in repairing urethral fistulas at the proximal urethral anastomosis.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Gokay Ozceltik, Ismet Hortu, Ismail Mete Itil, Ahmet Ozgur Yeniel
Summary: This study described a vaginal approach combining vaginal hysterectomy with transvaginal natural orifice transluminal endoscopic surgery for hysterectomy in transgender men and compared it with laparoscopy. The results showed that the vaginal approach had shorter operative times, less postoperative pain, and shorter hospital stays compared to laparoscopy.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2022)
Article
Surgery
Christopher J. Salgado, Kerstin Yu, Maria J. Lalama
Summary: Gender affirmation surgeries are performed to reduce patient's dysphoria and improve quality of life, with preservation of the vaginal canal and reproductive organs becoming increasingly discussed in trans men. This study examined surgical complexities of vaginal and reproductive organ preservation in patients undergoing phalloplasty, with postoperative results showing successful outcomes in terms of sensory perception and reduction in gender incongruence.
JOURNAL OF SURGICAL CASE REPORTS
(2021)
Article
Urology & Nephrology
Yasar Caliskan, Tiffany Caza, Amy Mosman, Usama Elawa, Marie Philipneri, Kevin Martin, Bahar Bastani
Summary: This case presents a rare form of kidney disease known as Anti-LDL Receptor-Related Protein 2 (Anti-LRP2) nephropathy, characterized by acute kidney injury and immune complex deposits in the proximal tubules. The patient exhibited features of acute kidney injury and nephrotic syndrome, with significant overlap in morphology with minimal change disease and anti-LRP2 nephropathy, highlighting the complexity of diagnosing and treating such conditions.
JOURNAL OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Tiffany N. Caza, Samar I. Hassen, Zeljko Dvanajscak, Michael Kuperman, Rick Edmondson, Christian Herzog, Aaron Storey, John Arthur, L. Nicholas Cossey, Shree G. Sharma, Daniel J. Kenan, Christopher P. Larsen
Summary: Patients with membranous nephropathy associated with malignancy were found to have unique NELL1 immune complexes in kidney biopsy tissue, with characteristic histopathology of incomplete capillary loop staining and IgG1 predominance. These NELL1-positive cases also showed a higher association with concurrent malignancy compared to other known types of membranous nephropathy.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Tiffany N. Caza, Samar I. Hassen, Michael Kuperman, Shree G. Sharma, Zeljko Dvanajscak, John Arthur, Rick Edmondson, Aaron Storey, Christian Herzog, Daniel J. Kenan, Christopher P. Larsen
Summary: Research has identified neural cell adhesion molecule 1 (NCAM1) as a target antigen in some cases of membranous lupus nephritis and rare cases of primary membranous nephropathy, colocalizing with IgG in glomerular immune deposits. Circulating antibodies to NCAM1 have been detected in serum of patients with NCAM1-associated membranous nephropathy, suggesting diagnostic significance. Future studies are needed to determine whether anti-NCAM1 antibody levels correlate with disease activity or response to therapy.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Laith Farah Al-Rabadi, Tiffany Caza, Claire Trivin-Avillach, Aylin R. Rodan, Nicole Andeen, Norifumi Hayashi, Brandi Williams, Monica P. Revelo, Fred Clayton, Jo Abraham, Edwin Lin, Willisa Liou, Chang-Jiang Zou, Nirupama Ramkumar, Tim Cummins, Daniel W. Wilkey, Issa Kawalit, Christian Herzog, Aaron Storey, Rick Edmondson, Ronald Sjoberg, Tianxin Yang, Jeremy Chien, Michael Merchant, John Arthur, Jon Klein, Chris Larsen, Laurence H. Beck
Summary: The study identified serine protease HTRA1 as a novel podocyte antigen in primary membranous nephropathy (MN) patients. Anti-HTRA1 antibodies in patients with HTRA1-associated MN were predominantly IgG4 and seemed to correlate with clinical disease activity. Screening of 118 quadruple-negative patients revealed a 4.2% prevalence of HTRA1-associated MN.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Letter
Pathology
Sanjay A. Pai, Bidisha Bhaduri, Supraja Chandrasekar, Phalguni Anand Alladi, Tiffany Caza, Anita Mahadevan, T. R. Saiprasad, Patrick Walker
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Letter
Urology & Nephrology
Tiffany N. Caza, Christopher P. Larsen
KIDNEY INTERNATIONAL
(2022)
Article
Oncology
Angelina Regua, Csaba Papp, Andre Grageda, Baylee A. Porter, Tiffany Caza, Isabelle Bichindaritz, Mira Krendel, Abirami Sivapiragasam, Gennady Bratslavsky, Vladimir A. Kuznetsov, Leszek Kotula
Summary: Breast cancer remains one of the leading causes of mortality in women worldwide, and there is a need for better predictive and therapeutic targets. This study identifies ABI1 as a prognostic biomarker for breast cancer metastasis and demonstrates that genetic disruption of the ABI1 gene reduces lung metastases in mice. The study also shows that aberrations in ABI1 gene expression are associated with lung metastasis in primary breast cancer tumors. Targeting ABI1 may provide a therapeutic advantage for breast cancer patients.
MOLECULAR ONCOLOGY
(2022)
Letter
Urology & Nephrology
Shruti Gupta, Tiffany Caza, Sandra M. Herrmann, Vipulbhai C. Sakhiya, Kenar D. Jhaveri
KIDNEY INTERNATIONAL REPORTS
(2022)
Letter
Urology & Nephrology
Johann Morelle, Tiffany Caza, Hanna Debiec, Selda Aydin, Aaron Storey, Pierre Ronco, Christopher Larsen
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Tiffany N. Caza, Laith F. Al-Rabadi
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Medical Laboratory Technology
T. I. F. F. A. N. Y. CAZA, C. H. A. T. H. U. R. A. WIJEWARDENA, L. A. I. T. H. AL-RABADI, A. N. D. R. A. S. PERL
Summary: Pro-inflammatory immune system development, metabolomic defects, and deregulation of autophagy are interconnected in driving the pathogenesis of systemic lupus erythematosus (SLE), specifically lupus nephritis (LN). Defects in autophagy and mitophagy lead to the accumulation of oxidative stress-generating mitochondria and necrotic cell death. The activation of mTOR and aberrant autophagy promote the expansion of pro-inflammatory cells and compromise end-organ resistance in LN. mTOR activation has been identified as a biomarker for disease activation and prognosis in SLE patients.
TRANSLATIONAL RESEARCH
(2022)
Article
Immunology
Pallavi Manral, Tiffany N. Caza, Aaron J. Storey, Laurence H. Beck, Dorin-Bogdan Borza
Summary: This study analyzed the serum of patients with THSD7A-associated membranous nephropathy and found that predominantly IgG4 anti-THSD7A antibodies can activate the complement system, but at high IgG4 density and through the alternative pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Michael Kuperman, Shree Sharma, Alejandro Best, Manisha Singh, Tiffany Caza
Summary: Kidney pathology education is crucial for nephrology fellows and practicing nephrologists. The use of digital learning, especially during the pandemic, has made nephrology a leader in online medical education. Resources such as medical blogs, journal clubs, interactive quizzes and games, online conferences, podcasts, and mentorship opportunities can supplement nephropathology training.
ADVANCES IN CHRONIC KIDNEY DISEASE
(2022)
Article
Urology & Nephrology
Tiffany N. Caza, Clarissa A. Cassol, Nidia Messias, Andrew Hannoudi, Randy S. Haun, Patrick D. Walker, Rebecca M. May, Regan M. Seipp, Elizabeth J. Betchick, Hassan Amin, Mandolin S. Ziadie, Michael Haderlie, Joy Eduwu-Okwuwa, Irina Vancea, Melvin Seek, Essam B. Elashi, Ganesh Shenoy, Sayeed Khalillullah, Jesse A. Flaxenburg, John Brandt, Matthew J. Diamond, Adam Frome, Eugene H. Kim, Gregory Schlessinger, Erlandas Ulozas, Janice L. Weatherspoon, Ethan Thomas Hoerschgen, Steven L. Fabian, Sung Yong Bae, Bilal Iqbal, Kanwalijit K. Chouhan, Zeina Karam, James T. Henry, Christopher P. Larsen
Summary: Vaccination against SARS-CoV-2 may trigger kidney diseases in susceptible individuals, but the overall incidence is low and should be closely monitored for as a potential adverse event.
Article
Urology & Nephrology
Tiffany N. Caza, Samar Hassen, Daniel J. Kenan, Aaron Storey, John M. Arthur, Christian Herzog, Rick D. Edmondson, T. David Bourne, Laurence H. Beck, Christopher P. Larsen
Summary: A novel biomarker, TGFBR3, expressed in a subset of patients with MLN, was found to be a distinct form of MN significantly enriched in MLN. Diagnosis of TGFBR3-associated MN can alert clinicians to search for underlying autoimmune diseases and guide treatment decisions to improve patient prognosis.