Nutritional strategies for mucosal health: the interplay between microbes and mucin glycans

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

(2020) Lucy I. Crouch et al.   Nature Communications

Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations

(2020) K. M. Pruss et al.   ISME Journal

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

(2020) Kirk Bergstrom et al.   SCIENCE

Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila

(2020) Beatriz Trastoy et al.   Nature Communications

Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization

(2020) Fátima C. Pereira et al.   Nature Communications

Akkermansia muciniphila uses human milk oligosaccharides to thrive in the early life conditions in vitro

(2020) Ioannis Kostopoulos et al.   Scientific Reports

Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals

(2020) Stefania Vaga et al.   Scientific Reports

Bacteroides thetaiotaomicron Fosters the Growth of Butyrate-Producing Anaerostipes caccae in the Presence of Lactose and Total Human Milk Carbohydrates

(2020) Loo Wee Chia et al.   Microorganisms

Engineering mucus to study and influence the microbiome

(2019) Caroline Werlang et al.   Nature Reviews Materials

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice

(2019) Benthe van der Lugt et al.   Immunity & Ageing

Shaping the Infant Microbiome With Non-digestible Carbohydrates

(2019) Stella Verkhnyatskaya et al.   Frontiers in Microbiology

The effect of 2′-fucosyllactose on simulated infant gut microbiome and metabolites; a pilot study in comparison to GOS and lactose

(2019) Krista Salli et al.   Scientific Reports

Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

(2019) Andrew Bell et al.   Nature Microbiology

The biology of mucus: Composition, synthesis and organization

(2018) Rama Bansil et al.   ADVANCED DRUG DELIVERY REVIEWS

Two extracellular sialidases from Bifidobacterium bifidum promote the degradation of sialyl-oligosaccharides and support the growth of Bifidobacterium breve

(2018) Keita Nishiyama et al.   ANAEROBE

Ecology and evolution of metabolic cross-feeding interactions in bacteria

(2018) Glen D'Souza et al.   NATURAL PRODUCT REPORTS

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

(2018) Eric C. Martens et al.   NATURE REVIEWS MICROBIOLOGY

Glycan Utilization and Cross-Feeding Activities by Bifidobacteria

(2018) Francesca Turroni et al.   TRENDS IN MICROBIOLOGY

Fight them or feed them: how the intestinal mucus layer manages the gut microbiota

(2018) Bjoern O Schroeder   Gastroenterology Report

Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants

(2017) Chloe A Autran et al.   GUT

Longitudinal change of selected human milk oligosaccharides and association to infants’ growth, an observatory, single center, longitudinal cohort study

(2017) Norbert Sprenger et al.   PLoS One

Bifidobacterium bifidum Extracellular Sialidase Enhances Adhesion to the Mucosal Surface and Supports Carbohydrate Assimilation

(2017) Keita Nishiyama et al.   mBio

Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts

(2017) Clara Belzer et al.   mBio

Interactions of Intestinal Bacteria with Components of the Intestinal Mucus

(2017) Jean-Félix Sicard et al.   Frontiers in Cellular and Infection Microbiology

A Metagenomics Investigation of Carbohydrate-Active Enzymes along the Gastrointestinal Tract of Saudi Sheep

(2017) Saad Al-Masaudi et al.   Frontiers in Microbiology

Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

(2017) Noora Ottman et al.   PLoS One

A cross-sectional comparative study of gut bacterial community of Indian and Finnish children

(2017) Shreyas V. Kumbhare et al.   Scientific Reports

Sialidases from gut bacteria: a mini-review

(2016) N. Juge et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

FUT2-dependent breast milk oligosaccharides and allergy at 2 and 5 years of age in infants with high hereditary allergy risk

(2016) Norbert Sprenger et al.   EUROPEAN JOURNAL OF NUTRITION

An introduction to the sugar code

(2016) Hans-Joachim Gabius et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Potential Benefits of Dietary Fibre Intervention in Inflammatory Bowel Disease

(2016) Celestine Wong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Characterization of Outer Membrane Proteome of Akkermansia muciniphila Reveals Sets of Novel Proteins Exposed to the Human Intestine

(2016) Noora Ottman et al.   Frontiers in Microbiology

Human Clostridium difficile infection: altered mucus production and composition

(2015) Melinda A. Engevik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mucin glycan foraging in the human gut microbiome

(2015) Louise E. Tailford et al.   Frontiers in Genetics

Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates

(2014) Erica D. Sonnenburg et al.   Cell Metabolism

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation

(2014) YingYing He et al.   GUT

The first thousand days - intestinal microbiology of early life: establishing a symbiosis

(2014) Harm Wopereis et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

(2013) Abdessamad El Kaoutari et al.   NATURE REVIEWS MICROBIOLOGY

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human milk oligosaccharide consumption by intestinal microbiota

(2012) A. Marcobal et al.   CLINICAL MICROBIOLOGY AND INFECTION

Human milk oligosaccharides: Every baby needs a sugar mama

(2012) L. Bode   GLYCOBIOLOGY

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

How glycan metabolism shapes the human gut microbiota

(2012) Nicole M. Koropatkin et al.   NATURE REVIEWS MICROBIOLOGY

Association study ofFUT2(rs601338) with celiac disease and inflammatory bowel disease in the Finnish population

(2012) A. S. Parmar et al.   TISSUE ANTIGENS

Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways

(2011) Angela Marcobal et al.   Cell Host & Microbe

The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats

(2011) Evelyn Jantscher-Krenn et al.   GUT

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype

(2011) P. Rausch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of Polysaccharide Use in Intestinal Bacteroides Species Determines Diet-Induced Microbiota Alterations

(2010) Erica D. Sonnenburg et al.   CELL

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

(2010) Dermot P.B. McGovern et al.   HUMAN MOLECULAR GENETICS

Insights into the evolution of sialic acid catabolism among bacteria

(2009) Salvador Almagro-Moreno et al.   BMC EVOLUTIONARY BIOLOGY

Mucin Degradation by Bifidobacterium Strains Isolated from the Human Intestinal Microbiota

(2008) P. Ruas-Madiedo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY