Primary ciliary signaling: links with the cell cycle

CEP55 promotes cilia disassembly through stabilizing Aurora A kinase

(2021) Yu-Cheng Zhang et al.   JOURNAL OF CELL BIOLOGY

LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis

(2021) Huai-Bin Hu et al.   Nature Communications

Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

(2021) Daishi Yamakawa et al.   Cell Reports

PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress

(2020) Asma Boukhalfa et al.   Nature Communications

Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis

(2020) Linda Viol et al.   JOURNAL OF CELL BIOLOGY

KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling

(2020) Petra Pejskova et al.   JOURNAL OF CELL BIOLOGY

Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the IFT machinery is required for intraciliary retrograde protein trafficking

(2020) Kentaro Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway

(2020) Sarah Findakly et al.   JOURNAL OF CELL BIOLOGY

RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis

(2020) Muhammad Farooq et al.   Nature Communications

High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy

(2019) Mathew Bowler et al.   Nature Communications

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

(2019) Michaela Kunova Bosakova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs

(2019) Anna A Kiseleva et al.   CLINICAL CANCER RESEARCH

The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases

(2019) Francesca Finetti et al.   CELL DEATH AND DIFFERENTIATION

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

(2019) Vijay Walia et al.   DEVELOPMENTAL CELL

Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding

(2019) Mary Mirvis et al.   PLOS BIOLOGY

Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism

(2018) Ae Lee Jeong et al.   EMBO REPORTS

Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies

(2018) Michaela Kunova Bosakova et al.   HUMAN MOLECULAR GENETICS

EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

(2018) Kousuke Kasahara et al.   Nature Communications

Cilium structure, assembly, and disassembly regulated by the cytoskeleton

(2018) Mary Mirvis et al.   BIOCHEMICAL JOURNAL

Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine

(2018) Min Jung Kong et al.   Redox Biology

A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice

(2018) Matthew J. Ford et al.   DEVELOPMENTAL CELL

Cilia-Associated Oxysterols Activate Smoothened

(2018) David R. Raleigh et al.   MOLECULAR CELL

Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia

(2017) Ludovic Martin et al.   HUMAN MOLECULAR GENETICS

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma

(2017) S E Conduit et al.   ONCOGENE

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

CPAP promotes timely cilium disassembly to maintain neural progenitor pool

(2016) Elke Gabriel et al.   EMBO JOURNAL

HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma

(2016) Tetsuo Kobayashi et al.   EMBO REPORTS

Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway

(2016) Hironori Inaba et al.   JOURNAL OF CELL BIOLOGY

Ciliopathies: Does HDAC6 Represent a New Therapeutic Target?

(2016) Fan Yu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Posttranslational Modifications of Tubulin and Cilia

(2016) Dorota Wloga et al.   Cold Spring Harbor Perspectives in Biology

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

The Intraflagellar Transport Machinery

(2016) Michael Taschner et al.   Cold Spring Harbor Perspectives in Biology

Tubulin acetylation: responsible enzymes, biological functions and human diseases

(2015) Lin Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IFT–Cargo Interactions and Protein Transport in Cilia

(2015) Karl F. Lechtreck   TRENDS IN BIOCHEMICAL SCIENCES

Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle

(2015) Sehyun Kim et al.   Nature Communications

Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

(2015) Jongshin Kim et al.   Nature Communications

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

(2014) Irene Franco et al.   DEVELOPMENTAL CELL

Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension

(2014) Kousuke Kasahara et al.   Nature Communications

Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division

(2013) Judith T.M.L. Paridaen et al.   CELL

The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies

(2012) Junmin Pan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells

(2012) Akihito Inoko et al.   JOURNAL OF CELL BIOLOGY

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis

(2012) Olga V. Plotnikova et al.   MOLECULAR BIOLOGY OF THE CELL

Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

(2011) Søren T Christensen et al.   JOURNAL OF PATHOLOGY

Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors

(2011) Aiqun Li et al.   NATURE CELL BIOLOGY

Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry

(2011) Sehyun Kim et al.   NATURE CELL BIOLOGY

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry

(2010) Doris Kinzel et al.   DEVELOPMENTAL CELL

A mutation in the 3′-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia

(2010) Delphine Simon et al.   HUMAN MOLECULAR GENETICS

Acetylation of Microtubules Influences Their Sensitivity to Severing by Katanin in Neurons and Fibroblasts

(2010) H. Sudo et al.   JOURNAL OF NEUROSCIENCE

Functional genomic screen for modulators of ciliogenesis and cilium length

(2010) Joon Kim et al.   NATURE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

(2009) Shuying Liu et al.   CANCER CELL

Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia

(2009) E. S. Seeley et al.   CANCER RESEARCH

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

The ubiquitin conjugation system is involved in the disassembly of cilia and flagella

(2009) Kaiyao Huang et al.   JOURNAL OF CELL BIOLOGY

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

(2009) Stephanie L Bielas et al.   NATURE GENETICS