Journal
SMALL
Volume 17, Issue 29, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202100789
Keywords
core-satellite nanosystems; light-triggered nanostructure disassembly; metal phenolic networks; size-switchable nanosystems; tumor penetration
Categories
Funding
- National Natural Science Foundation of China [81 572 998, 81 773 274, 82 073 379]
- Shanghai Municipal Science and Technology Commission [16 520 710 700]
- Shu Guang Program of Shanghai Education Development Foundation
- Shanghai Municipal Education Commission [16SG13]
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Metal-phenolic networks have been utilized to develop a unique core-satellite nanosystem for enhanced solid tumor treatment, with the disassembly triggered by light leading to improved outcomes in tumor-bearing mice.
Metal-phenolic networks (MPNs) are an emerging class of supramolecular surface modifiers with potential use in various fields including drug delivery. Here, the development of a unique MPN-integrated core-satellite nanosystem (CS-NS) is reported. The core component of CS-NS comprises a liposome loaded with EDTA (a metal ion chelator) in the aqueous core and DiR (a near-infrared photothermal transducer) in the bilayer. The satellite component comprises mesoporous silica nanoparticles (MSNs) encapsulating doxorubicin and is coated with a Cu2+-tannic acid MPN. Liposomes and MSNs self-assemble into the CS-NS through adhesion mediated by the MPN. When irradiated with an 808 nm laser, CS-NS liberated the entrapped EDTA, leading to Cu2+ chelation and subsequent disassembly of the core-satellite nanostructure. Photo-conversion from the large assembly to the small constituent particles proceeded within 5 min. Light-triggered CS-NS disassembly enhanced the carrier and cargo penetration and accumulation in tumor spheroids in vitro and in orthotopic murine mammary tumors in vivo. CS-NS is long circulating in the blood and conferred improved survival outcomes to tumor-bearing mice treated with light, compared to controls. These results demonstrate an MPN-integrated multistage nanosystem for improved solid tumor treatment.
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