Pathophysiology of Bronchiectasis

Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma

(2021) Bruno Sposato et al.   Clinical Respiratory Journal

Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program

(2021) Annette T Hastie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Predictive value of blood eosinophil count in COPD

(2021) Shiping Zhu et al.   RESPIROLOGY

The Relationship Between Symptoms, Exacerbations and Treatment Response in Bronchiectasis

(2020) Yong-hua Gao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis

(2020) Tuang Yeow Poh et al.   CHEST

The airway microbiome in COPD, bronchiectasis and bronchiectasis‐COPD overlap

(2020) Pei Yee Tiew et al.   Clinical Respiratory Journal

Pseudomonas aeruginosa isolates from cystic fibrosis patients induce neutrophil extracellular traps with different morphologies that could correlate with their disease severity

(2020) S. Martínez-Alemán et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

(2020) James D. Chalmers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of inhaled corticosteroids in reducing exacerbations in bronchiectasis patients with blood eosinophilia pooled post-hoc analysis of 2 randomized clinical trials

(2020) Miguel Angel Martinez-Garcia et al.   RESPIRATORY MEDICINE

Outcomes of protracted bacterial bronchitis in children: A 5‐year prospective cohort study

(2020) Tom J.C. Ruffles et al.   RESPIROLOGY

Impact of asthma on bronchiectasis severity and risk of exacerbations

(2020) Sebastian Ferri et al.   JOURNAL OF ASTHMA

Pseudomonas aeruginosa associated with severity of non-cystic fibrosis bronchiectasis measured by the modified bronchiectasis severity score (BSI) and the FACED: The US bronchiectasis and NTM Research Registry (BRR) study

(2020) Radmila Choate et al.   RESPIRATORY MEDICINE

Pathophysiology, causes and genetics of paediatric and adult bronchiectasis

(2019) Andrew Bush et al.   RESPIROLOGY

Safety and efficacy of the human neutrophil elastase inhibitor BAY 85-8501 for the treatment of non-cystic fibrosis bronchiectasis: a randomized controlled trial

(2019) Henrik Watz et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Comparative risks of chronic inhaled corticosteroids and macrolides for bronchiectasis

(2019) Emily Henkle et al.   EUROPEAN RESPIRATORY JOURNAL

A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

(2019) Amelia Shoemark et al.   EUROPEAN RESPIRATORY JOURNAL

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis

(2019) Oriol Sibila et al.   THORAX

A longitudinal characterization of the Non-Cystic Fibrosis Bronchiectasis airway microbiome

(2019) T. E. Woo et al.   Scientific Reports

Blood eosinophil count as a predictor of hospital length of stay in COPD exacerbations

(2019) Fanny W.S. Ko et al.   RESPIROLOGY

The microbiome in bronchiectasis

(2019) Hollian Richardson et al.   European Respiratory Review

Allergic bronchopulmonary aspergillosis

(2019) Gayatri Patel et al.   ALLERGY AND ASTHMA PROCEEDINGS

Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis

(2019) Kathryn A Ramsey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis

(2019) James D Chalmers et al.   Lancet Respiratory Medicine

Primary ciliary dyskinesia in the genomics age

(2019) Jane S Lucas et al.   Lancet Respiratory Medicine

The clinical characteristics and prognosis of ABPA are closely related to the mucus plugs in central bronchiectasis

(2019) Hai‐Wen Lu et al.   Clinical Respiratory Journal

Characterization of the “Frequent Exacerbator Phenotype” in Bronchiectasis

(2018) James D. Chalmers et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Blood Neutrophils are Reprogrammed in Bronchiectasis.

(2018) Pallavi Bedi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bronchiectasis in severe asthma

(2018) Isabel Coman et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

IMMUNOLOGICAL COROLLARY OF THE PULMONARY MYCOBIOME IN BRONCHIECTASIS: THE CAMEB STUDY

(2018) Micheál Mac Aogáin et al.   EUROPEAN RESPIRATORY JOURNAL

Secreted phosphatase and deoxyribonuclease are required by Pseudomonas aeruginosa to defend against neutrophil extracellular traps.

(2018) Mike Wilton et al.   INFECTION AND IMMUNITY

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

(2018) Alison J. Dicker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Viruses in bronchiectasis: a pilot study to explore the presence of community acquired respiratory viruses in stable patients and during acute exacerbations

(2018) Alicia B. Mitchell et al.   BMC Pulmonary Medicine

Bronchiectasis: new therapies and new perspectives

(2018) James D Chalmers et al.   Lancet Respiratory Medicine

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity

(2018) Patrick A Flume et al.   LANCET

Emerging therapies in adult and paediatric bronchiectasis

(2018) Kate H. Regan et al.   RESPIROLOGY

The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis

(2018) Ren-Jay Shei et al.   CURRENT OPINION IN PHARMACOLOGY

Blood eosinophil count and exacerbation risk in patients with COPD

(2017) Marjan Kerkhof et al.   EUROPEAN RESPIRATORY JOURNAL

Standardised classification of the aetiology of bronchiectasis using an objective algorithm

(2017) David Araújo et al.   EUROPEAN RESPIRATORY JOURNAL

Pseudomonas aeruginosaadaptation and diversification in the non-cystic fibrosis bronchiectasis lung

(2017) Yasmin Hilliam et al.   EUROPEAN RESPIRATORY JOURNAL

European Respiratory Society guidelines for the management of adult bronchiectasis

(2017) Eva Polverino et al.   EUROPEAN RESPIRATORY JOURNAL

Profile of the ProAxsis active neutrophil elastase immunoassay for precision medicine in chronic respiratory disease

(2017) Holly R Keir et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

(2017) Robert D Gray et al.   THORAX

Primary Ciliary Dyskinesia: An Update on Clinical Aspects, Genetics, Diagnosis, and Future Treatment Strategies

(2017) Virginia Mirra et al.   Frontiers in Pediatrics

Longitudinal assessment of sputum microbiome by sequencing of the 16S rRNA gene in non-cystic fibrosis bronchiectasis patients

(2017) Michael J. Cox et al.   PLoS One

Is Alveolar Macrophage Phagocytic Dysfunction in Children With Protracted Bacterial Bronchitis a Forerunner to Bronchiectasis?

(2016) Sandra Hodge et al.   CHEST

A longitudinal study characterising a large adult primary ciliary dyskinesia population

(2016) Anand Shah et al.   EUROPEAN RESPIRATORY JOURNAL

Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases

(2016) Israel Hanukoglu et al.   GENE

Virulence adaptations of Pseudomonas aeruginosa isolated from patients with non-cystic fibrosis bronchiectasis

(2016) Taylor E. Woo et al.   MICROBIOLOGY-SGM

Diagnostic challenges of bronchiectasis

(2016) Guillermo Suarez-Cuartin et al.   RESPIRATORY MEDICINE

Aetiology of bronchiectasis in adults: A systematic literature review

(2016) Yong-hua Gao et al.   RESPIROLOGY

Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa

(2016) Madison Floyd et al.   PLoS Pathogens

Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps

(2016) Elmar Pieterse et al.   Frontiers in Immunology

Persistent Sputum Cellularity and Neutrophils May Predict Bronchiectasis

(2016) Nicole Drost et al.   Canadian Respiratory Journal

Chronic Infection by MucoidPseudomonas aeruginosaAssociated with Dysregulation in T-Cell Immunity to Outer Membrane Porin F

(2015) Kathryn J. Quigley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease

(2015) Eva P. Szymanski et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Role of Viral Infection in Pulmonary Exacerbations of Bronchiectasis in Adults

(2015) Yong-hua Gao et al.   CHEST

A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis

(2015) Anthony De Soyza et al.   EUROPEAN RESPIRATORY JOURNAL

Nasal potential difference of carriers of the W493R ENaC variant with non-cystic fibrosis bronchiectasis: TABLE 1

(2015) Jessica Rademacher et al.   EUROPEAN RESPIRATORY JOURNAL

Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study

(2015) Jennifer K. Quint et al.   EUROPEAN RESPIRATORY JOURNAL

Changes in airway inflammation during pulmonary exacerbations in patients with cystic fibrosis and primary ciliary dyskinesia

(2015) Felix Ratjen et al.   EUROPEAN RESPIRATORY JOURNAL

Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

(2015) Luke W. Garratt et al.   EUROPEAN RESPIRATORY JOURNAL

Should diffuse bronchiectasis still be considered a CFTR-related disorder?

(2015) Anne Bergougnoux et al.   Journal of Cystic Fibrosis

Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis

(2015) Federico L. Dente et al.   MEDIATORS OF INFLAMMATION

Secreted mucins and airway bacterial colonization in non-CF bronchiectasis

(2015) Oriol Sibila et al.   RESPIROLOGY

Efficiency and safety of surgical intervention to patients with Non-Cystic Fibrosis bronchiectasis: a meta-analysis

(2015) Li-Chao Fan et al.   Scientific Reports

Lung disease in primary antibody deficiency

(2015) Nisha Verma et al.   Lancet Respiratory Medicine

Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis–like Lung Disease

(2014) Stefanie Gehrig et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Bronchiectasis Severity Index. An International Derivation and Validation Study

(2014) James D. Chalmers et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Systematic review/Meta-analysis Prevalence of nontuberculous mycobacteria in patients with bronchiectasis: a meta-analysis

(2014) Haiqing Chu et al.   Archives of Medical Science

Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function

(2014) C. Nair et al.   EUROPEAN RESPIRATORY JOURNAL

A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis

(2014) M.W. Konstan et al.   Journal of Cystic Fibrosis

The effect of long-term macrolide treatment on respiratory microbiota composition in non-cystic fibrosis bronchiectasis: an analysis from the randomised, double-blind, placebo-controlled BLESS trial

(2014) Geraint B Rogers et al.   Lancet Respiratory Medicine

Defining severity in non-cystic fibrosis bronchiectasis

(2014) Lucy Poppelwell et al.   Expert Review of Respiratory Medicine

Genetic Testing in the Diagnosis of Primary Ciliary Dyskinesia: State-of-the-Art and Future Perspectives

(2014) Samuel Collins et al.   Journal of Clinical Medicine

Airway Clearance in Bronchiectasis: Breaking the Infection–Inflammation Cycle

(2013) Rob G. Stirling et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung Microbiota and Bacterial Abundance in Patients with Bronchiectasis when Clinically Stable and during Exacerbation

(2013) Michael M. Tunney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease

(2013) Michael R. Knowles et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs

(2013) Gerd Döring et al.   Journal of Cystic Fibrosis

Modulation of gene expression by Pseudomonas aeruginosa during chronic infection in the adult cystic fibrosis lung

(2013) C. Harmer et al.   MICROBIOLOGY-SGM

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyocyanin-Enhanced Neutrophil Extracellular Trap Formation Requires the NADPH Oxidase

(2013) Balázs Rada et al.   PLoS One

Phenotyping adults with non-cystic fibrosis bronchiectasis: A prospective observational cohort study

(2013) G.A. Anwar et al.   RESPIRATORY MEDICINE

Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis

(2013) Robert Stockley et al.   RESPIRATORY MEDICINE

Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

(2013) Hikari Koga et al.   RESPIRATORY RESEARCH

Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis

(2013) Marie-Hélène Ruchaud-Sparagano et al.   RESPIROLOGY

Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition

(2013) Geraint B Rogers et al.   THORAX

Short- and Long-Term Antibiotic Treatment Reduces Airway and Systemic Inflammation in Non–Cystic Fibrosis Bronchiectasis

(2012) James D. Chalmers et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Patients with Nontuberculous Mycobacterial Lung Disease Exhibit Unique Body and Immune Phenotypes

(2012) Marinka Kartalija et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Influence of DNA on the Activities and Inhibition of Neutrophil Serine Proteases in Cystic Fibrosis Sputum

(2012) Alice V. Dubois et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Granulomatosis-associated common variable immunodeficiency disorder: a case-control study versus sarcoidosis

(2012) D. Bouvry et al.   EUROPEAN RESPIRATORY JOURNAL

Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis

(2012) James D. Chalmers et al.   MOLECULAR IMMUNOLOGY

Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis

(2012) James D Chalmers et al.   THORAX

The Th17 Pathway in Cystic Fibrosis Lung Disease

(2011) Hui-Leng Tan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The airway microbiome in cystic fibrosis and implications for treatment

(2011) Edith T Zemanick et al.   CURRENT OPINION IN PEDIATRICS

Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR

(2011) Robert L. Young et al.   PLoS One

Cystic Fibrosis Transmembrane Conductance Regulator Channel Dysfunction in Non–Cystic Fibrosis Bronchiectasis

(2010) Thierry Bienvenu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Slender, Older Women Appear to Be More Susceptible to Nontuberculous Mycobacterial Lung Disease

(2010) Edward D. Chan et al.   Gender Medicine

NontypeableHaemophilus influenzaeInitiates Formation of Neutrophil Extracellular Traps

(2010) Richard A. Juneau et al.   INFECTION AND IMMUNITY

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Human Neutrophil Peptides and Phagocytic Deficiency in Bronchiectatic Lungs

(2009) Stefanos Voglis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Combination of ENaC and CFTR mutations may predispose to cystic fibrosis-like disease

(2009) I. Fajac et al.   EUROPEAN RESPIRATORY JOURNAL

Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease

(2009) Abul Kalam Azad et al.   HUMAN MUTATION

Sputum Proteomics in Inflammatory and Suppurative Respiratory Diseases

(2008) Robert D. Gray et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms

(2008) S. Fuschillo et al.   EUROPEAN RESPIRATORY JOURNAL

Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

(2008) Heidi Mulcahy et al.   PLoS Pathogens

Animal models of human pneumonia

(2007) Joseph P. Mizgerd et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY