The TLR7 agonist vesatolimod induced a modest delay in viral rebound in HIV controllers after cessation of antiretroviral therapy

Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption

(2020) Julie L. Mitchell et al.   JOURNAL OF CLINICAL INVESTIGATION

Virologic and immunologic features of SIV control post ART interruption in rhesus macaques

(2020) Zachary Strongin et al.   JOURNAL OF VIROLOGY

Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers Despite Waning T-Cell Responses During Antiretroviral Therapy

(2020) Nikolaus Jilg et al.   JOURNAL OF INFECTIOUS DISEASES

Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA

(2020) Francesco R. Simonetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vesatolimod, a toll-like receptor 7 agonist, induces immune activation in virally suppressed adults with HIV-1

(2020) Sharon A Riddler et al.   CLINICAL INFECTIOUS DISEASES

Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy

(2020) Rajesh T Gandhi et al.   JOURNAL OF INFECTIOUS DISEASES

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

(2020) Chenyang Jiang et al.   NATURE

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

(2019) Marilia Rita Pinzone et al.   Nature Communications

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

PD-1 blockade and TLR7 activation lack therapeutic benefit in chronic SIV-infected macaques on antiretroviral therapy

(2019) Elena Bekerman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Why and where an HIV cure is needed and how it might be achieved

(2019) Thumbi Ndung’u et al.   NATURE

Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells

(2019) Son Nguyen et al.   Science Translational Medicine

Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV

(2018) Youry Kim et al.   Cell Host & Microbe

Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells

(2018) Katja Srpan et al.   JOURNAL OF CELL BIOLOGY

Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B

(2018) Harry L.A. Janssen et al.   JOURNAL OF HEPATOLOGY

Safety and Efficacy of Vesatolimod (GS-9620) in Patients with Chronic Hepatitis B Who Are Not Currently on Antiviral Treatment

(2018) Kosh Agarwal et al.   JOURNAL OF VIRAL HEPATITIS

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

(2018) So-Yon Lim et al.   Science Translational Medicine

The Control of HIV after Antiretroviral Medication Pause (CHAMP) study: post-treatment controllers identified from 14 clinical studies

(2018) Golnaz Namazi et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

(2018) Erica N. Borducchi et al.   NATURE

HIV control: Is getting there the same as staying there?

(2018) Philip Goulder et al.   PLoS Pathogens

Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

(2017) Angela Tsai et al.   JOURNAL OF VIROLOGY

Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys

(2017) Nicolas Huot et al.   NATURE MEDICINE

Advancements in Developing Strategies for Sterilizing and Functional HIV Cures

(2017) Wei Xu et al.   Biomed Research International

Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

(2016) Erica N. Borducchi et al.   NATURE

The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruption

(2015) Jonathan Z. Li et al.   AIDS

The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection

(2015) Edward J. Gane et al.   JOURNAL OF HEPATOLOGY

Post-treatment control of HIV infection

(2015) Jessica M. Conway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist

(2013) Uri Lopatin et al.   ANTIVIRAL THERAPY

GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

(2013) Robert E. Lanford et al.   GASTROENTEROLOGY

Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers

(2013) Tae-Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

(2013) Asier Sáez-Cirión et al.   PLoS Pathogens

Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers

(2010) A. L. Ferre et al.   JOURNAL OF VIROLOGY

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

(2010)   SCIENCE

Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

(2008) Stephen A. Migueles et al.   IMMUNITY

Magnitude and Complexity of Rectal Mucosa HIV-1-Specific CD8+ T-Cell Responses during Chronic Infection Reflect Clinical Status

(2008) J. William Critchfield et al.   PLoS One