Disruption of circadian rhythm and risk of autism spectrum disorder: role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways

Altered circadian rhythms in a mouse model of neurodevelopmental disorders based on prenatal maternal immune activation

(2021) Tara C. Delorme et al.   BRAIN BEHAVIOR AND IMMUNITY

Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder

(2021) Sébastien Lalanne et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications

(2020) George Anderson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular Interactions Between Components of the Circadian Clock and the Immune System

(2020) Sophia Hergenhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Sleep, Growth, and Puberty After Two Years of Prolonged-Release Melatonin in Children With Autism Spectrum Disorder

(2020) Beth A. Malow et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Oxidative Stress in Autism Spectrum Disorder

(2020) Geir Bjørklund et al.   MOLECULAR NEUROBIOLOGY

Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice

(2020) Hitoshi Inokawa et al.   Scientific Reports

Circadian rhythm disruption and mental health

(2020) William H. Walker et al.   Translational Psychiatry

Sleep Onset Problems and Subcortical Development in Infants Later Diagnosed With Autism Spectrum Disorder

(2020) Katherine E. MacDuffie et al.   AMERICAN JOURNAL OF PSYCHIATRY

Diurnal Patterns of Gene Expression in the Dorsal Vagal Complex and the Central Nucleus of the Amygdala – Non-rhythm-generating Brain Regions

(2020) Mary M. Staehle et al.   Frontiers in Neuroscience

Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder

(2020) Zhou Dan et al.   Gut Microbes

Inflammation and Mitochondrial Dysfunction in Autism Spectrum Disorder

(2020) Maria Gevezova et al.   CNS & Neurological Disorders-Drug Targets

The role of glutathione redox imbalance in autism spectrum disorder: A review

(2020) Geir Bjørklund et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disturbances of Continuous Sleep and Circadian Rhythms Account for Behavioral Difficulties in Children with Autism Spectrum Disorder

(2020) Enise Yavuz-Kodat et al.   Journal of Clinical Medicine

Autism spectrum disorder (ASD): Disturbance of the melatonin system and its implications

(2020) Zhou-yue Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut microbiota changes in patients with autism spectrum disorders

(2020) Xue Ding et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The Association between Autistic Traits and Sleep Habits/Problems in Toddlers

(2020) Fumie Horiuchi et al.   DEVELOPMENTAL NEUROPSYCHOLOGY

Cell-autonomous clock of astrocytes drives circadian behavior in mammals

(2019) Marco Brancaccio et al.   SCIENCE

Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder

(2019) Simeng Liu et al.   Scientific Reports

Saliva microRNA Differentiates Children With Autism From Peers With Typical and Atypical Development

(2019) Steven D. Hicks et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Microbiome diurnal rhythmicity and its impact on host physiology and disease risk

(2019) Samuel Philip Nobs et al.   EMBO REPORTS

DNA Methylation and Susceptibility to Autism Spectrum Disorder

(2019) Martine W. Tremblay et al.   Annual Review of Medicine

Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD)

(2019) Galen Missig et al.   NEUROPSYCHOPHARMACOLOGY

Shank3 modulates sleep and expression of circadian transcription factors

(2019) Ashley M Ingiosi et al.   eLife

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

(2019) Gabriella E. DiCarlo et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Per3, a circadian clock gene, in embryonic development of mouse cerebral cortex

(2019) Mariko Noda et al.   Scientific Reports

Circadian Rhythms and Measures of CNS/Autonomic Interaction

(2019) Francesco Riganello et al.   International Journal of Environmental Research and Public Health

Systematic Review of Sleep Disturbances and Circadian Sleep Desynchronization in Autism Spectrum Disorder: Toward an Integrative Model of a Self-Reinforcing Loop

(2019) Claudia Carmassi et al.   Frontiers in Psychiatry

Differences in Diurnal Variation of Immune Responses in Microglia and Macrophages: Review and Perspectives

(2019) Ricardo J. Martínez-Tapia et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Integrating Autism Spectrum Disorder Pathophysiology: Mitochondria, Vitamin A, CD38, Oxytocin, Serotonin and Melatonergic Alterations in the Placenta and Gut

(2019) Michael Maes et al.   CURRENT PHARMACEUTICAL DESIGN

Autism Spectrum Disorders: Role of Pre- and Post-natal GammaDelta (γδ) T Cells and Immune Regulation

(2019) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

Gut-Amygdala Interactions in Autism Spectrum Disorders: Developmental Roles via regulating Mitochondria, Exosomes, Immunity and microRNAs

(2019) Moonsang Seo et al.   CURRENT PHARMACEUTICAL DESIGN

Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells

(2019) George Anderson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-β) in children with autism spectrum disorder

(2019) Mai Moaaz et al.   JOURNAL OF NEUROIMMUNOLOGY

Differential regulation of Nrf2 is linked to elevated inflammation and nitrative stress in monocytes of children with autism

(2019) Ahmed Nadeem et al.   PSYCHONEUROENDOCRINOLOGY

Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2

(2018) Mikyung Kim et al.   Biomolecules & Therapeutics

The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development

(2018) Yunho Jin et al.   MOLECULES

Immune aberrations in children with Autism Spectrum Disorder: a case-control study from a tertiary care neuropsychiatric hospital in India

(2018) Salah Basheer et al.   PSYCHONEUROENDOCRINOLOGY

Proliferation and apoptosis of T lymphocytes in patients with bipolar disorder

(2018) Krzysztof Pietruczuk et al.   Scientific Reports

Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders

(2018) Lam Son Nguyen et al.   Molecular Autism

Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models

(2018) Jamie Horder et al.   Translational Psychiatry

Post hoc analysis of plasma amino acid profiles: towards a specific pattern in autism spectrum disorder and intellectual disability

(2018) Jean-Baptiste Delaye et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Transcriptional control of synaptic components by the clock machinery

(2018) Lydia Hannou et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rhythms of life: circadian disruption and brain disorders across the lifespan

(2018) Ryan W. Logan et al.   NATURE REVIEWS NEUROSCIENCE

Synaptopathology Involved in Autism Spectrum Disorder

(2018) Shiqi Guang et al.   Frontiers in Cellular Neuroscience

The genetics of circadian rhythms, sleep and health

(2017) Aarti Jagannath et al.   HUMAN MOLECULAR GENETICS

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

(2017) David Druzd et al.   IMMUNITY

Tryptophan status in autism spectrum disorder and the influence of supplementation on its level

(2017) Joanna Kałużna-Czaplińska et al.   METABOLIC BRAIN DISEASE

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

(2017) M V Lombardo et al.   MOLECULAR PSYCHIATRY

Conceptualising compensation in neurodevelopmental disorders: Reflections from autism spectrum disorder

(2017) Lucy Anne Livingston et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and Non-Energy-Related Mechanisms

(2017) Keren K. Griffiths et al.   Oxidative Medicine and Cellular Longevity

Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System

(2017) Kirill S. Korshunov et al.   Frontiers in Cellular Neuroscience

Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders

(2017) Cécile Pagan et al.   Scientific Reports

Role of a circadian-relevant gene NR1D1 in brain development: possible involvement in the pathophysiology of autism spectrum disorders

(2017) Masahide Goto et al.   Scientific Reports

Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches

(2017) Ning Cheng et al.   Frontiers in Molecular Neuroscience

Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice

(2017) Benjamin L. Smarr et al.   Scientific Reports

Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients

(2016) Zhiliang Yang et al.   BRAIN & DEVELOPMENT

Sodium butyrate protects mice from the development of the early signs of non-alcoholic fatty liver disease: role of melatonin and lipid peroxidation

(2016) Cheng Jun Jin et al.   BRITISH JOURNAL OF NUTRITION

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

(2016) Christoph A. Thaiss et al.   CELL

Potential serum biomarkers from a metabolomics study of autism

(2016) Han Wang et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model

(2016) Neta Kratsman et al.   NEUROPHARMACOLOGY

The Role of the Immune System in Autism Spectrum Disorder

(2016) Amory Meltzer et al.   NEUROPSYCHOPHARMACOLOGY

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci

(2016) Samuel E. Jones et al.   PLoS Genetics

Circadian clock proteins control adaptation to novel environment and memory formation

(2016) Anna A.Kondratova et al.   Aging-US

Circadian clock genes: Effects on dopamine, reward and addiction

(2015) Puja K. Parekh et al.   ALCOHOL

Microglia inflammatory responses are controlled by an intrinsic circadian clock

(2015) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

Influence of circadian disruption on neurotransmitter levels, physiological indexes, and behaviour in rats

(2015) Takeru Matsumura et al.   CHRONOBIOLOGY INTERNATIONAL

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

(2015) Anastasia I. Petra et al.   CLINICAL THERAPEUTICS

Circadian Clocks in the Immune System

(2015) Nathalie Labrecque et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men

(2015) Jonathan Cedernaes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clock Genes Control Cortical Critical Period Timing

(2015) Yohei Kobayashi et al.   NEURON

Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China

(2015) Fengzhen Huang et al.   PLoS One

Circadian rhythm of homocysteine is hCLOCK genotype dependent

(2014) Basil Paul et al.   MOLECULAR BIOLOGY REPORTS

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

(2014) A Masi et al.   MOLECULAR PSYCHIATRY

The developmental disruptions of serotonin signaling may involved in autism during early brain development

(2014) C.-J. Yang et al.   NEUROSCIENCE

Circadian Disorganization Alters Intestinal Microbiota

(2014) Robin M. Voigt et al.   PLoS One

Altered circadian patterns of salivary cortisol in low-functioning children and adolescents with autism

(2014) Sylvie Tordjman et al.   PSYCHONEUROENDOCRINOLOGY

Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

(2014) Daniel A. Rossignol et al.   Frontiers in Physiology

Temporal Regulation of Cytokines by the Circadian Clock

(2014) Atsuhito Nakao   Journal of Immunology Research

Crosstalk between the circadian clock circuitry and the immune system

(2013) Nicolas Cermakian et al.   CHRONOBIOLOGY INTERNATIONAL

Abnormal circadian rhythm and cortisol excretion in autistic children: a clinical study

(2013) Malarveni Damodaran Lakshmi Priya et al.   CROATIAN MEDICAL JOURNAL

Regulation of Circadian Clocks by Redox Homeostasis

(2013) Alessandra Stangherlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

(2013) P J Hamilton et al.   MOLECULAR PSYCHIATRY

Decreased tryptophan metabolism in patients with autism spectrum disorders

(2013) Luigi Boccuto et al.   Molecular Autism

Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism

(2013) Eleonora Napoli et al.   Molecular Autism

Redox metabolism abnormalities in autistic children associated with mitochondrial disease

(2013) R E Frye et al.   Translational Psychiatry

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

(2012) Melissa Wilking et al.   ANTIOXIDANTS & REDOX SIGNALING

The circadian clock geneBMAL1is a novel therapeutic target for malignant pleural mesothelioma

(2012) Momen Elshazley et al.   INTERNATIONAL JOURNAL OF CANCER

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

(2012) Yukimasa Takeda et al.   NUCLEIC ACIDS RESEARCH

Neuroimaging and Neurochemistry of Autism

(2012) Diane C. Chugani   PEDIATRIC CLINICS OF NORTH AMERICA

Diurnal Variation of Hepatic Antioxidant Gene Expression in Mice

(2012) Yi-Qiao Xu et al.   PLoS One

CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses

(2012) A. G. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

(2012) S Rose et al.   Translational Psychiatry

Circadian rhythms and memory formation: regulation by chromatin remodeling

(2012) Saurabh Sahar et al.   Frontiers in Molecular Neuroscience

Cu/Zn superoxide dismutase is differentially regulated in period gene-mutant mice

(2011) Yeong-Su Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells

(2011) Adam C. Silver et al.   BRAIN BEHAVIOR AND IMMUNITY

MicroRNA networks direct neuronal development and plasticity

(2011) N. F. M. Olde Loohuis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism

(2011) Abha Chauhan et al.   JOURNAL OF NEUROCHEMISTRY

Circadian Regulation of ATP Release in Astrocytes

(2011) L. Marpegan et al.   JOURNAL OF NEUROSCIENCE

Developmental disruption of the serotonin system alters circadian rhythms

(2011) Erin V. Paulus et al.   PHYSIOLOGY & BEHAVIOR

Circadian Clocks in Mouse and Human CD4+ T Cells

(2011) Thomas Bollinger et al.   PLoS One

Disruption of circadian clocks has ramifications for metabolism, brain, and behavior

(2011) I. N. Karatsoreos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of metabolism: the circadian clock dictates the time

(2011) Saurabh Sahar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gut Microbiota and Inflammation

(2011) Asa Hakansson et al.   Nutrients

Rapid Eye Movement Sleep Percentage in Children With Autism Compared With Children With Developmental Delay and Typical Development

(2010) Ashura Williams Buckley et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Knockdown of Clock in the Ventral Tegmental Area Through RNA Interference Results in a Mixed State of Mania and Depression-Like Behavior

(2010) Shibani Mukherjee et al.   BIOLOGICAL PSYCHIATRY

Evaluation of Oxidative Stress in Autism: Defective Antioxidant Enzymes and Increased Lipid Peroxidation

(2010) Nagwa A. Meguid et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Mutation screening of melatonin-related genes in patients with autism spectrum disorders

(2010) Lina Jonsson et al.   BMC Medical Genomics

Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome

(2010) Paul Ashwood et al.   BRAIN BEHAVIOR AND IMMUNITY

Long-term sleep disturbances in children: A cause of neuronal loss

(2010) James E. Jan et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain

(2010) AnhThu Nguyen et al.   FASEB JOURNAL

Dysregulation of Inflammatory Responses by Chronic Circadian Disruption

(2010) O. Castanon-Cervantes et al.   JOURNAL OF IMMUNOLOGY

Identification of Pathway-Biased and Deleterious Melatonin Receptor Mutants in Autism Spectrum Disorders and in the General Population

(2010) Pauline Chaste et al.   PLoS One

Interactions of the circadian CLOCK system and the HPA axis

(2010) Nancy Nader et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines

(2010) Tewarit Sarachana et al.   Genome Medicine

Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism

(2009) Valerie W. Hu et al.   Autism Research

Temporal dynamics of mouse hippocampal clock gene expression support memory processing

(2009) Antje Jilg et al.   HIPPOCAMPUS

Circadian rhythms and sleep in children with autism

(2009) Gena Glickman   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Relationship between whole blood serotonin and repetitive behaviors in autism

(2009) Alexander Kolevzon et al.   PSYCHIATRY RESEARCH

Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood

(2008) Gabriele Hampp et al.   CURRENT BIOLOGY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Genetic Differences in Human Circadian Clock Genes among Worldwide Populations

(2008) Christopher M. Ciarleglio et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Examining cortisol rhythmicity and responsivity to stress in children with Tourette syndrome

(2008) B.A. Corbett et al.   PSYCHONEUROENDOCRINOLOGY