APPsα rescues impaired Ca2+ homeostasis in APP- and APLP2-deficient hippocampal neurons
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
APPsα rescues impaired Ca2+ homeostasis in APP- and APLP2-deficient hippocampal neurons
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 26, Pages e2011506118
Publisher
Proceedings of the National Academy of Sciences
Online
2021-06-26
DOI
10.1073/pnas.2011506118
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling
- (2019) Maria Calvo-Rodriguez et al. Frontiers in Cellular Neuroscience
- Glutamate receptor trafficking and protein synthesis mediate the facilitation of ltp by secreted amyloid precursor protein-alpha
- (2019) Bruce G. Mockett et al. JOURNAL OF NEUROSCIENCE
- In vivo Ca 2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria
- (2019) Elena Montagna et al. GLIA
- Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition
- (2018) Max C Richter et al. EMBO JOURNAL
- Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease
- (2018) Valerie T. Y. Tan et al. Molecular Brain
- Downregulation of AβPP Enhances Both Calcium Content of Endoplasmic Reticulum and Acidic Stores and the Dynamics of Store Operated Calcium Channel Activity
- (2018) Maria Chatzistavraki et al. JOURNAL OF ALZHEIMERS DISEASE
- Not just amyloid: physiological functions of the amyloid precursor protein family
- (2017) Ulrike C. Müller et al. NATURE REVIEWS NEUROSCIENCE
- Axonal Endoplasmic Reticulum Ca 2+ Content Controls Release Probability in CNS Nerve Terminals
- (2017) Jaime de Juan-Sanz et al. NEURON
- Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity
- (2017) Susann Ludewig et al. Frontiers in Molecular Neuroscience
- Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα
- (2017) Bruce G. Mockett et al. Frontiers in Molecular Neuroscience
- γ-Secretase Catalyzes Sequential Cleavages of the AβPP Transmembrane Domain
- (2017) Xuemin Xu JOURNAL OF ALZHEIMERS DISEASE
- Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum
- (2017) Kinga Gazda et al. Scientific Reports
- When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer’s Disease
- (2016) Mario Agostini et al. CELL CALCIUM
- Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis
- (2016) Chengyu Zou et al. EMBO JOURNAL
- Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels
- (2016) D. Hefter et al. JOURNAL OF NEUROSCIENCE
- Neuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome
- (2016) Kristin Michaelsen-Preusse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry
- (2016) Benjamin Chun-Kit Tong et al. Science Signaling
- Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry
- (2016) Benjamin Chun-Kit Tong et al. Science Signaling
- Calcium Imaging of AM Dyes Following Prolonged Incubation in Acute Neuronal Tissue
- (2016) Morven Cameron et al. PLoS One
- Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model
- (2015) Romain Fol et al. ACTA NEUROPATHOLOGICA
- Store-operated calcium entry compensates fast ER calcium loss in resting hippocampal neurons
- (2015) Samira Samtleben et al. CELL CALCIUM
- APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression
- (2015) Sarah L. Cousins et al. JOURNAL OF NEUROCHEMISTRY
- Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease
- (2015) H. Zhang et al. JOURNAL OF NEUROSCIENCE
- Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production
- (2015) Mark A. Lovell et al. Oxidative Medicine and Cellular Longevity
- Store-Operated Calcium Channels
- (2015) Murali Prakriya et al. PHYSIOLOGICAL REVIEWS
- Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity
- (2014) Meike Hick et al. ACTA NEUROPATHOLOGICA
- Molecular mechanism of intramembrane proteolysis by γ-secretase
- (2014) Taisuke Tomita JOURNAL OF BIOCHEMISTRY
- The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons
- (2014) B. Wang et al. JOURNAL OF NEUROSCIENCE
- Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice
- (2014) Suya Sun et al. NEURON
- SynPAnal: Software for Rapid Quantification of the Density and Intensity of Protein Puncta from Fluorescence Microscopy Images of Neurons
- (2014) Eric Danielson et al. PLoS One
- Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function
- (2012) Brea Midthune et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Critical role of soluble amyloid- for early hippocampal hyperactivity in a mouse model of Alzheimer's disease
- (2012) M. A. Busche et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein
- (2011) Cristina I. Linde et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: The case for isradipine
- (2011) Thimmappa S. Anekonda et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
- (2011) Sascha W Weyer et al. EMBO JOURNAL
- Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging
- (2011) Donat Kögel et al. EXPERIMENTAL BRAIN RESEARCH
- Calcium Signaling and Amyloid Toxicity in Alzheimer Disease
- (2010) Angelo Demuro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines
- (2010) K.J. Lee et al. NEUROSCIENCE
- The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity
- (2009) Hyang-Sook Hoe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery
- (2009) Sarah L. Cousins et al. JOURNAL OF NEUROCHEMISTRY
- Expression of Human Amyloid Precursor Protein in Rat Cortical Neurons Inhibits Calcium Oscillations
- (2009) S. F. Santos et al. JOURNAL OF NEUROSCIENCE
- Amyloid Precursor Protein Regulates Cav1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity
- (2009) L. Yang et al. JOURNAL OF NEUROSCIENCE
- Calcium hypothesis of Alzheimer’s disease
- (2009) Michael J. Berridge PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death
- (2009) A. Berna-Erro et al. Science Signaling
- Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease
- (2008) Lukasz Bojarski et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
- (2008) Chanel J. Taylor et al. NEUROBIOLOGY OF DISEASE
- Linking Calcium to Aβ and Alzheimer's Disease
- (2008) Kim N. Green et al. NEURON
- Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks
- (2008) Kishore V. Kuchibhotla et al. NEURON
- Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
- (2008) Ilya Bezprozvanny et al. TRENDS IN NEUROSCIENCES
- Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse
- (2007) Guillermo Rojas et al. EXPERIMENTAL NEUROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now