Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling

The guidance receptor plexin D1 is a mechanosensor in endothelial cells

(2020) Vedanta Mehta et al.   NATURE

Smooth Muscle Cell Reprogramming in Aortic Aneurysms

(2020) Pei-Yu Chen et al.   Cell Stem Cell

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

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Shear Stress Attenuates Inward Remodeling in Cultured Mouse Thoracodorsal Arteries in an eNOS-Dependent, but Not Hemodynamic Manner, and Increases Cx37 Expression

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HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer

(2018) Fei Huang et al.   CANCER RESEARCH

Key transcriptional regulators of the vasoprotective effects of shear stress

(2018) R. A. Boon et al.   Hamostaseologie

Identification of bone morphogenetic protein 9 (BMP9) as a novel profibrotic factor in vitro

(2016) José M. Muñoz-Félix et al.   CELLULAR SIGNALLING

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

(2016) Nicolas Baeyens et al.   JOURNAL OF CELL BIOLOGY

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

(2016) Roxana Ola et al.   Nature Communications

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical activity of alvocidib (flavopiridol) in acute myeloid leukemia

(2015) Joshua F. Zeidner et al.   LEUKEMIA RESEARCH

Targeting BMP signalling in cardiovascular disease and anaemia

(2015) Nicholas W. Morrell et al.   Nature Reviews Cardiology

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

(2015) Nicolas Baeyens et al.   eLife

The role of ERK5 in endothelial cell function

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Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling

(2014) Nicolas Baeyens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit

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Transforming growth factor-β signalling: Role and consequences of Smad linker region phosphorylation

(2013) Danielle Kamato et al.   CELLULAR SIGNALLING

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

(2012) Pei-Yu Chen et al.   Cell Reports

The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation

(2011) Xing Chang et al.   IMMUNITY

Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis

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PECAM-1 Is Necessary for Flow-Induced Vascular Remodeling

(2009) Zhongming Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

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Identification ofN-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design†

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