Elementary mechanisms of calmodulin regulation of NaV1.5 producing divergent arrhythmogenic phenotypes

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

SCN 2A channelopathies: Mechanisms and models

(2020) Ulrike B. S. Hedrich et al.   EPILEPSIA

EF hand‐like motif mutations of Nav1.4 C‐terminus cause myotonic syndrome by impairing fast inactivation

(2020) Riho Horie et al.   MUSCLE & NERVE

E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms

(2020) Colin H. Peters et al.   JOURNAL OF GENERAL PHYSIOLOGY

Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding–deficient channels

(2020) Jeffrey Abrams et al.   JCI Insight

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening

(2020) Po Wei Kang et al.   Science Advances

Structural basis of α-scorpion toxin action on Nav channels

(2019) Thomas Clairfeuille et al.   SCIENCE

Crystal structures of Ca2+–calmodulin bound to NaV C-terminal regions suggest role for EF-hand domain in binding and inactivation

(2019) Bernd R. Gardill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif

(2019) Jesse B. Yoder et al.   Nature Communications

Modulation of cardiac ryanodine receptor 2 by calmodulin

(2019) Deshun Gong et al.   NATURE

Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels

(2019) William A. Catterall et al.   Annual Review of Pharmacology and Toxicology

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF

(2019) Aravind R. Gade et al.   JOURNAL OF GENERAL PHYSIOLOGY

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

(2019) Jakub Tomek et al.   eLife

Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels

(2018) Rahul Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel

(2018) Christopher N. Johnson et al.   STRUCTURE

Progress in Understanding and Treating SCN2A -Mediated Disorders

(2018) Stephan J. Sanders et al.   TRENDS IN NEUROSCIENCES

The voltage-gated sodium channel EF-hands form an interaction with the III-IV linker that is disturbed by disease-causing mutations

(2018) Bernd R. Gardill et al.   Scientific Reports

Calmodulin limits pathogenic Na+channel persistent current

(2017) Haidun Yan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants

(2017) Mena Abdelsayed et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

SCN8Aencephalopathy: Research progress and prospects

(2016) Miriam H. Meisler et al.   EPILEPSIA

Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins

(2016) Geoffrey S. Pitt et al.   PROTEIN SCIENCE

Uncovering Aberrant Mutant PKA Function with Flow Cytometric FRET

(2016) Shin-Rong Lee et al.   Cell Reports

Calmodulin and Ca2+control of voltage gated Na+channels

(2015) Sandra B Gabelli et al.   Channels

Ion Channel Macromolecular Complexes in Cardiomyocytes: Roles in Sudden Cardiac Death

(2015) H. Abriel et al.   CIRCULATION RESEARCH

Intracellular Calcium Attenuates Late Current Conducted by Mutant Human Cardiac Sodium Channels

(2015) Franck Potet et al.   Circulation-Arrhythmia and Electrophysiology

Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice

(2015) Elaine Wan et al.   JOURNAL OF CLINICAL INVESTIGATION

Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels

(2015) Manu Ben-Johny et al.   Current Molecular Pharmacology

Conservation of Ca2+/Calmodulin Regulation across Na and Ca2+ Channels

(2014) Manu Ben-Johny et al.   CELL

Regulation of the NaV1.5 cytoplasmic domain by calmodulin

(2014) Sandra B. Gabelli et al.   Nature Communications

Structural analyses of Ca2+/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation

(2014) Chaojian Wang et al.   Nature Communications

FGF12 is a candidate Brugada syndrome locus

(2013) Jessica A. Hennessey et al.   HEART RHYTHM

Cardiac sodium channelopathy associated withSCN5Amutations: electrophysiological, molecular and genetic aspects

(2013) Carol Ann Remme   JOURNAL OF PHYSIOLOGY-LONDON

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

(2013) Manu Ben Johny et al.   Nature Communications

Seeing the Forest through the Trees: towards a Unified View on Physiological Calcium Regulation of Voltage-Gated Sodium Channels

(2012) Filip Van Petegem et al.   BIOPHYSICAL JOURNAL

Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel NaV1.5 Gating by Multiple Phosphorylation Sites

(2012) Nicole M. Ashpole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystallographic basis for calcium regulation of sodium channels

(2012) M. F. Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin

(2012) Chaojian Wang et al.   STRUCTURE

Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation

(2012) Ian W. Glaaser et al.   Nature Communications

Structural and Energetic Determinants of Apo Calmodulin Binding to the IQ Motif of the NaV1.2 Voltage-Dependent Sodium Channel

(2011) Michael D. Feldkamp et al.   STRUCTURE

Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation

(2010) Felix Findeisen et al.   Channels

Solution NMR Structure of Apo-Calmodulin in Complex with the IQ Motif of Human Cardiac Sodium Channel NaV1.5

(2010) Benjamin Chagot et al.   JOURNAL OF MOLECULAR BIOLOGY

Calcium-Mediated Dual-Mode Regulation of Cardiac Sodium Channel Gating

(2009) Subrata Biswas et al.   CIRCULATION RESEARCH

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

(2009) Jamie D. Kapplinger et al.   HEART RHYTHM

Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin

(2009) Franck Potet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution NMR Structure of the C-terminal EF-hand Domain of Human Cardiac Sodium Channel NaV1.5

(2008) Benjamin Chagot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCN5A channelopathies – An update on mutations and mechanisms

(2008) Thomas Zimmer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY