Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation
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Title
Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 34, Pages e2025813118
Publisher
Proceedings of the National Academy of Sciences
Online
2021-08-21
DOI
10.1073/pnas.2025813118
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Note: Only part of the references are listed.- Developmental trajectory of oligodendrocyte progenitor cells in the human brain revealed by single cell RNA sequencing
- (2020) Kelly Perlman et al. GLIA
- Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain
- (2020) Jeroen F.J. Bogie et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis
- (2019) Tessa Dhaeze et al. Cellular & Molecular Immunology
- Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
- (2019) Hong-Gyun Lee et al. Nature Communications
- Altered human oligodendrocyte heterogeneity in multiple sclerosis
- (2019) Sarah Jäkel et al. NATURE
- Distinct Function-Related Molecular Profile of Adult Human A2B5-Positive Pre-Oligodendrocytes Versus Mature Oligodendrocytes
- (2019) Caroline Esmonde-White et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis
- (2019) Rhonda R. Voskuhl et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis
- (2019) Jaime Gonzalez Cardona et al. PLoS One
- β1-Integrin– and KV1.3 channel–dependent signaling stimulates glutamate release from Th17 cells
- (2019) Katharina Birkner et al. JOURNAL OF CLINICAL INVESTIGATION
- T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention
- (2018) Jamie van Langelaar et al. BRAIN
- Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation
- (2018) Christina F. Vogelaar et al. Science Translational Medicine
- Laminins and their receptors in the CNS
- (2018) Abhijit Nirwane et al. BIOLOGICAL REVIEWS
- Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury
- (2018) Edwin Vázquez-Rosa et al. ACS Chemical Neuroscience
- Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis
- (2018) Ana Mendanha Falcão et al. NATURE MEDICINE
- An updated histological classification system for multiple sclerosis lesions
- (2016) Tanja Kuhlmann et al. ACTA NEUROPATHOLOGICA
- Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells
- (2016) Darius Ebrahimi-Fakhari et al. HUMAN MOLECULAR GENETICS
- Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study
- (2016) Eva Havrdová et al. JOURNAL OF NEUROLOGY
- Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
- (2016) Christian Schläger et al. NATURE
- Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?
- (2016) Catherine Larochelle et al. TRENDS IN NEUROSCIENCES
- Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation
- (2015) Catherine Larochelle et al. ANNALS OF NEUROLOGY
- MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
- (2015) James T. Walsh et al. JOURNAL OF CLINICAL INVESTIGATION
- Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells
- (2015) Jasmin Herz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Transfer of Myelin-Reactive Th17 Cells Impairs Endogenous Remyelination in the Central Nervous System of Cuprizone-Fed Mice
- (2015) E. G. Baxi et al. JOURNAL OF NEUROSCIENCE
- Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression
- (2015) H. Rolyan et al. JOURNAL OF NEUROSCIENCE
- FRET based ratiometric Ca2+ imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis
- (2015) Volker Siffrin et al. JOURNAL OF NEUROSCIENCE METHODS
- Pathological mechanisms in progressive multiple sclerosis
- (2015) Don H Mahad et al. LANCET NEUROLOGY
- Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic
- (2015) Sharon W. Way et al. Nature Communications
- IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments
- (2014) Dirk W. Luchtman et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Direct and Indirect Effects of Immune and Central Nervous System–Resident Cells on Human Oligodendrocyte Progenitor Cell Differentiation
- (2014) Craig S. Moore et al. JOURNAL OF IMMUNOLOGY
- Mutation of 3-Hydroxy-3-Methylglutaryl CoA Synthase I Reveals Requirements for Isoprenoid and Cholesterol Synthesis in Oligodendrocyte Migration Arrest, Axon Wrapping, and Myelin Gene Expression
- (2014) E. S. Mathews et al. JOURNAL OF NEUROSCIENCE
- Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis
- (2014) Manuel A. Friese et al. Nature Reviews Neurology
- 2-photon imaging of phagocyte-mediated T cell activation in the CNS
- (2013) Marija Pesic et al. JOURNAL OF CLINICAL INVESTIGATION
- Cytotoxic NKG2C+ CD4 T Cells Target Oligodendrocytes in Multiple Sclerosis
- (2013) F. Zaguia et al. JOURNAL OF IMMUNOLOGY
- The human oligodendrocyte proteome
- (2013) Keiko Iwata et al. PROTEOMICS
- Oligodendrocytes and the early multiple sclerosis lesion
- (2012) John W. Prineas et al. ANNALS OF NEUROLOGY
- Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation
- (2012) Peter J. Darlington et al. ANNALS OF NEUROLOGY
- Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system
- (2012) Catherine Larochelle et al. BRAIN
- Neuroprotection and repair in multiple sclerosis
- (2012) Robin J. M. Franklin et al. Nature Reviews Neurology
- How do immune cells overcome the blood-brain barrier in multiple sclerosis?
- (2011) Catherine Larochelle et al. FEBS LETTERS
- RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
- (2011) Laura Codarri et al. NATURE IMMUNOLOGY
- Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing
- (2010) Chad M. Paton et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Expanding Two-Photon Intravital Microscopy to the Infrared by Means of Optical Parametric Oscillator
- (2010) Josephine Herz et al. BIOPHYSICAL JOURNAL
- Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing
- (2010) R. T. Boscacci et al. BLOOD
- In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis
- (2010) Volker Siffrin et al. IMMUNITY
- Myelination and the trophic support of long axons
- (2010) Klaus-Armin Nave NATURE REVIEWS NEUROSCIENCE
- Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis
- (2010) Ranjan Dutta et al. PROGRESS IN NEUROBIOLOGY
- Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis
- (2009) Hania Kebir et al. ANNALS OF NEUROLOGY
- Idiotope-specific CD4+ T cells induce apoptosis of human oligodendrocytes
- (2009) Anne Lise Karlsgot Hestvik et al. JOURNAL OF AUTOIMMUNITY
- Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes
- (2009) A. Jager et al. JOURNAL OF IMMUNOLOGY
- β1integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
- (2009) Martina Bauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biochemical and physiological function of stearoyl-CoA desaturase
- (2008) Chad M. Paton et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
- (2008) Bruce D. Trapp et al. Annual Review of Neuroscience
- Imaging of plasmacytoid dendritic cell interactions with T cells
- (2008) M. Mittelbrunn et al. BLOOD
- IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
- (2008) Stefan Haak et al. JOURNAL OF CLINICAL INVESTIGATION
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