ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 24, Pages e2025053118
Publisher
Proceedings of the National Academy of Sciences
Online
2021-06-08
DOI
10.1073/pnas.2025053118
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
- (2020) Chantell S Evans et al. eLife
- The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
- (2020) Valeria Gerbino et al. NEURON
- ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer
- (2020) Xiaoshan Shi et al. JOURNAL OF CELL BIOLOGY
- Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice
- (2019) David Brenner et al. JOURNAL OF EXPERIMENTAL MEDICINE
- LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
- (2019) Benjamin Scott Padman et al. Nature Communications
- Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
- (2019) Evandro F. Fang et al. NATURE NEUROSCIENCE
- Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
- (2019) Jose Norberto S. Vargas et al. MOLECULAR CELL
- ATG2 transports lipids to promote autophagosome biogenesis
- (2019) Diana P. Valverde et al. JOURNAL OF CELL BIOLOGY
- Recruitment and Activation of the ULK1/Atg1 Kinase Complex in Selective Autophagy
- (2019) Eleonora Turco et al. JOURNAL OF MOLECULAR BIOLOGY
- ilastik: interactive machine learning for (bio)image analysis
- (2019) Stuart Berg et al. NATURE METHODS
- TBK1‐mediated phosphorylation of LC3C and GABARAP‐L2 controls autophagosome shedding by ATG4 protease
- (2019) Lina Herhaus et al. EMBO REPORTS
- Effects of ALS-associated TANK binding kinase 1 mutations on protein–protein interactions and kinase activity
- (2019) Junqiang Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
- (2019) Shireen A. Sarraf et al. Cell Reports
- Hot-spot KIF5A mutations cause familial ALS
- (2018) David Brenner et al. BRAIN
- Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
- (2018) Sarah Pickles et al. CURRENT BIOLOGY
- Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics
- (2018) Alban Ordureau et al. MOLECULAR CELL
- ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function
- (2018) Martina de Majo et al. NEUROBIOLOGY OF AGING
- CellProfiler 3.0: Next-generation image processing for biology
- (2018) Claire McQuin et al. PLOS BIOLOGY
- Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology
- (2018) Mukesh Gautam et al. ACTA NEUROPATHOLOGICA
- Role of Mechanotransduction and Tension in T Cell Function
- (2018) Jérémie Rossy et al. Frontiers in Immunology
- RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
- (2018) J.-M. Heo et al. Science Advances
- Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy
- (2017) Rebecca J. Wilson et al. MITOCHONDRION
- Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?
- (2017) Jack van Horssen et al. NEUROSCIENCE LETTERS
- The TBK1-OPTN Axis Mediates Crosstalk Between Mitophagy and the Innate Immune Response: A Potential Therapeutic Target for Neurodegenerative Diseases
- (2017) Lu He et al. Neuroscience Bulletin
- Association of Mutations in TBK1 With Sporadic and Familial Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
- (2017) Axel Freischmidt et al. JAMA Neurology
- Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
- (2016) Wouter van Rheenen et al. NATURE GENETICS
- Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
- (2016) Benjamin Richter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy
- (2016) Andrew S. Moore et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
- (2016) Faxiang Li et al. Nature Communications
- Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
- (2016) Marco Onorati et al. Cell Reports
- Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes
- (2016) Christopher M. Rose et al. Cell Systems
- The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
- (2015) Jin-Mi Heo et al. MOLECULAR CELL
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
- (2015) Axel Freischmidt et al. NATURE NEUROSCIENCE
- TBK1 mutation frequencies in French frontotemporal dementia and amyotrophic lateral sclerosis cohorts
- (2015) Isabelle Le Ber et al. NEUROBIOLOGY OF AGING
- Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
- (2015) E. T. Cirulli et al. SCIENCE
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
- (2014) Lesley A. Kane et al. JOURNAL OF CELL BIOLOGY
- Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
- (2014) Alban Ordureau et al. MOLECULAR CELL
- Ubiquitin is phosphorylated by PINK1 to activate parkin
- (2014) Fumika Koyano et al. NATURE
- Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
- (2014) Yvette C. Wong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
- (2013) Shireen A. Sarraf et al. NATURE
- Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1
- (2013) Daqi Tu et al. Cell Reports
- Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1
- (2013) Amede Larabi et al. Cell Reports
- Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
- (2012) Takafumi Oka et al. NATURE
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation
- (2012) X. Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional Dissection of the TBK1 Molecular Network
- (2011) Adriana Goncalves et al. PLoS One
- Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
- (2011) P. Wild et al. SCIENCE
- Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
- (2010) Atsushi Tanaka et al. JOURNAL OF CELL BIOLOGY
- Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
- (2010) Seok Min Jin et al. JOURNAL OF CELL BIOLOGY
- Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
- (2008) Simon Morton et al. FEBS LETTERS
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started