Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates

Cellular and Subcellular Contact Guidance on Microfabricated Substrates

(2020) Claire Leclech et al.   Frontiers in Bioengineering and Biotechnology

Durotaxis by Human Cancer Cells

(2019) Brian J. DuChez et al.   BIOPHYSICAL JOURNAL

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

(2019) Neel I. Nissen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The extracellular matrix in tumor progression and metastasis

(2019) Johannes A. Eble et al.   CLINICAL & EXPERIMENTAL METASTASIS

Migration dynamics of ovarian epithelial cells on micro-fabricated image-based models of normal and malignant stroma

(2019) Samuel Alkmin et al.   Acta Biomaterialia

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

Bimodal sensing of guidance cues in mechanically distinct microenvironments

(2018) Erdem D. Tabdanov et al.   Nature Communications

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography

(2017) Elena I. Liang et al.   Integrative Biology

Force-dependent breaching of the basement membrane

(2017) Tammy T. Chang et al.   MATRIX BIOLOGY

Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions

(2017) Vinay Swaminathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments

(2017) Katrin Talkenberger et al.   Scientific Reports

Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments

(2017) Felix Spira et al.   eLife

Cell stiffness determined by atomic force microscopy and its correlation with cell motility

(2016) Qing Luo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

RHO binding to FAM65A regulates Golgi reorientation during cell migration

(2016) Faraz K. Mardakheh et al.   JOURNAL OF CELL SCIENCE

Tumor macrophages are pivotal constructors of tumor collagenous matrix

(2016) Ran Afik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly

(2016) Guilherme P. F. Nader et al.   NATURE CELL BIOLOGY

Dissection of molecular assembly dynamics by tracking orientation and position of single molecules in live cells

(2016) Shalin B. Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration

(2016) Emilie Pallesi-Pocachard et al.   Scientific Reports

3D texture analysis for classification of second harmonic generation images of human ovarian cancer

(2016) Bruce Wen et al.   Scientific Reports

Multiprotein Printing by Light-Induced Molecular Adsorption

(2015) Pierre-Olivier Strale et al.   ADVANCED MATERIALS

Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis

(2015) Amine Sadok et al.   CANCER RESEARCH

Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility

(2015) Verena Ruprecht et al.   CELL

Rac1-Dependent Phosphorylation and Focal Adhesion Recruitment of Myosin IIA Regulates Migration and Mechanosensing

(2015) Ana M. Pasapera et al.   CURRENT BIOLOGY

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Asymmetric nanotopography biases cytoskeletal dynamics and promotes unidirectional cell guidance

(2015) Xiaoyu Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

(2015) Bo Ri Seo et al.   Science Translational Medicine

Signaling Networks that Regulate Cell Migration

(2015) Peter Devreotes et al.   Cold Spring Harbor Perspectives in Biology

Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration

(2015) Jeremy S Logue et al.   eLife

Deactivation of a Negative Regulator: A Distinct Signal Transduction Mechanism, Pronounced in Akt Signaling

(2014) Anisur Rahman et al.   BIOPHYSICAL JOURNAL

Nonmuscle Myosin II Isoforms Coassemble in Living Cells

(2014) Jordan R. Beach et al.   CURRENT BIOLOGY

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLCγ/PKCα Pathway

(2014) Sreeja B. Asokan et al.   DEVELOPMENTAL CELL

The role of Rho GTPase in cell stiffness and cisplatin resistance in ovarian cancer cells

(2014) Shivani Sharma et al.   Integrative Biology

A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells

(2014) Dylan T. Burnette et al.   JOURNAL OF CELL BIOLOGY

FibrilTool, an ImageJ plug-in to quantify fibrillar structures in raw microscopy images

(2014) Arezki Boudaoud et al.   Nature Protocols

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

(2013) R A Patel et al.   ONCOGENE

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42

(2012) Jennifer Block et al.   CURRENT BIOLOGY

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Rapid and Quantitative Imaging of Excitation Polarized Fluorescence Reveals Ordered Septin Dynamics in Live Yeast

(2011) Bradley S. DeMay et al.   BIOPHYSICAL JOURNAL

Mechanical Stiffness Grades Metastatic Potential in Patient Tumor Cells and in Cancer Cell Lines

(2011) V. Swaminathan et al.   CANCER RESEARCH

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

A role for actin arcs in the leading-edge advance of migrating cells

(2011) Dylan T. Burnette et al.   NATURE CELL BIOLOGY

Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration

(2010) Sarah J. Heasman et al.   JOURNAL OF CELL BIOLOGY

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

(2009) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Asymmetric focal adhesion disassembly in motile cells

(2008) Joshua A Broussard et al.   CURRENT OPINION IN CELL BIOLOGY

Imaging amoeboid cancer cell motilityin vivo

(2008) S. PINNER et al.   JOURNAL OF MICROSCOPY

Mechanisms of actin stress fibre assembly

(2008) P. NAUMANEN et al.   JOURNAL OF MICROSCOPY

AFM-based analysis of human metastatic cancer cells

(2008) Sarah E Cross et al.   NANOTECHNOLOGY