Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers

Angiotensin II receptor agonist antibodies are associated with microvascular damage in lupus nephritis

(2020) J M Mejia-Vilet et al.   LUPUS

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

(2020) Laura M. Wingler et al.   SCIENCE

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

(2020) Ina Nemet et al.   CELL

Impact and production of Non‐HLA‐specific antibodies in solid organ transplantation

(2020) Xiaohai Zhang et al.   International Journal of Immunogenetics

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

(2019) Laura M. Wingler et al.   CELL

Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of AT1R Initiated by van der Waals Attraction

(2019) Khuraijam Dhanachandra Singh et al.   Journal of Chemical Information and Modeling

Biased Signaling and Allosteric Modulation at the FSHR

(2019) Flavie Landomiel et al.   Frontiers in Endocrinology

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes

(2019) Shoji Maeda et al.   SCIENCE

Diverse Responses of Autoantibodies to the Angiotensin II Type 1 Receptor in Primary Aldosteronism

(2019) Tracy Ann Williams et al.   HYPERTENSION

Antibodies Against GPCR

(2018) Harald Heidecke   Frontiers in Bioscience-Landmark

AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic RatsNovelty and Significance

(2018) Mark W. Cunningham et al.   HYPERTENSION

CASTp 3.0: computed atlas of surface topography of proteins

(2018) Wei Tian et al.   NUCLEIC ACIDS RESEARCH

PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?

(2018) Terry Kenakin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle

(2018) Lauren J. Albee et al.   Open Biology

Evaluation of angiotensin II type-1 receptor antibodies in primary aldosteronism and further considerations about their possible pathogenetic role

(2018) Chiara Sabbadin et al.   Journal of Clinical Hypertension

Divergent Spatiotemporal Interaction of Angiotensin Receptor Blocking Drugs with Angiotensin Type 1 Receptor

(2017) Khuraijam Dhanachandra Singh et al.   Journal of Chemical Information and Modeling

Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists

(2017) Jonathan M. Eby et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Angiotensin II for the Treatment of Vasodilatory Shock

(2017) Ashish Khanna et al.   NEW ENGLAND JOURNAL OF MEDICINE

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

(2016) Craig W. Lindsley et al.   CHEMICAL REVIEWS

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

(2015) Haitao Zhang et al.   CELL

Novel Retro-Inverso Peptide Inhibitor Reverses Angiotensin Receptor Autoantibody-Induced Hypertension in the Rabbit

(2015) H. Li et al.   HYPERTENSION

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor

(2015) Haitao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Revealing the favorable dissociation pathway of type II kinase inhibitors via enhanced sampling simulations and two-end-state calculations

(2015) Huiyong Sun et al.   Scientific Reports

Computational and statistical study on the molecular interaction between antigen and antibody

(2014) Tomonori Osajima et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Molecular modeling, quantum polarized ligand docking and structure-based 3D-QSAR analysis of the imidazole series as dual AT1 and ETA receptor antagonists

(2013) Khuraijam Dhanachandra Singh et al.   ACTA PHARMACOLOGICA SINICA

Angiotensin Receptor Agonistic Autoantibodies and Hypertension

(2013) Yang Xia et al.   CIRCULATION RESEARCH

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Long Range Effect of Mutations on Specific Conformational Changes in the Extracellular Loop 2 of Angiotensin II Type 1 Receptor

(2012) Hamiyet Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin type 1 receptor autoantibody from preeclamptic patients induces human fetoplacental vasoconstriction

(2012) Suli Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Monte Carlo Simulation Study of Methane Clathrate Hydrates Confined in Slit-Shaped Pores

(2012) Somendra Nath Chakraborty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Angiotensin II Type 1 Receptor Antibodies and Increased Angiotensin II Sensitivity in Pregnant Rats

(2011) Katrin Wenzel et al.   HYPERTENSION

Sex Chromosome Effects Unmasked in Angiotensin II–Induced Hypertension

(2010) Hong Ji et al.   HYPERTENSION

Ligand-specific Conformation of Extracellular Loop-2 in the Angiotensin II Type 1 Receptor

(2010) Hamiyet Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice

(2008) Cissy C Zhou et al.   NATURE MEDICINE