Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity

(2021) Vincent Legros et al.   Cellular & Molecular Immunology

Interactions between ibuprofen, ACE2, renin‐angiotensin system, and spike protein in the lung. Implications for COVID‐19

(2021) Rita Valenzuela et al.   Clinical and Translational Medicine

COVID-19: the gendered impacts of the outbreak

(2020) Clare Wenham et al.   LANCET

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

(2020) Liang Chen et al.   CARDIOVASCULAR RESEARCH

The Variety of Cardiovascular Presentations of COVID-19

(2020) Justin A. Fried et al.   CIRCULATION

The Spectrum of Cardiac Manifestations in Coronavirus Disease 2019 (COVID-19) - a Systematic Echocardiographic Study.

(2020) Yishay Szekely et al.   CIRCULATION

Air pollution, racial disparities, and COVID-19 mortality

(2020) Eric B. Brandt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The many faces of the anti-COVID immune response

(2020) Santosha A. Vardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy

(2020) Leo Nicolai et al.   CIRCULATION

Unexpected Features of Cardiac Pathology in COVID-19 Infection

(2020) Sharon E. Fox et al.   CIRCULATION

What about COVID-19 and arachidonic acid pathway?

(2020) Malvina Hoxha   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease

(2020) Christoph Schultheiß et al.   IMMUNITY

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Age-dependent effects in the transmission and control of COVID-19 epidemics

(2020) Nicholas G. Davies et al.   NATURE MEDICINE

Severe COVID-19 virus reactivation following treatment for B cell acute lymphoblastic leukemia

(2020) Guido Lancman et al.   Journal of Hematology & Oncology

Characterizing superspreading events and age-specific infectiousness of SARS-CoV-2 transmission in Georgia, USA

(2020) Max S. Y. Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: a dichotomy of expectation and reality

(2020) Lucinda Smart et al.   INFLAMMOPHARMACOLOGY

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

COX2 inhibition in the treatment of COVID-19: Review of literature to propose repositioning of celecoxib for randomized controlled studies

(2020) Semih Baghaki et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction

(2019) Lisa Schmidleithner et al.   IMMUNITY

Prostaglandin E2–Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti–PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection

(2019) Yamato Sajiki et al.   JOURNAL OF IMMUNOLOGY

Immune evasion before tumour invasion in early lung squamous carcinogenesis

(2019) Céline Mascaux et al.   NATURE

PGE2 ameliorated viral myocarditis development and promoted IL-10-producing regulatory B cell expansion via MAPKs/AKT-AP1 axis or AhR signaling

(2019) Rong Chen et al.   CELLULAR IMMUNOLOGY

T cell–intrinsic prostaglandin E 2 -EP2/EP4 signaling is critical in pathogenic T H 17 cell–driven inflammation

(2018) Jinju Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2/prostaglandin E2 content

(2018) Yuanyuan Wang et al.   METABOLIC BRAIN DISEASE

Prostaglandin E2 As a Modulator of Viral Infections

(2017) Willem J. Sander et al.   Frontiers in Physiology

Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin

(2017) Tina Tang et al.   Scientific Reports

Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins

(2014) Sheng-Fan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prostaglandin E2: the Villain in the Host Response to Influenza Virus

(2014) Florian Full et al.   IMMUNITY

Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages

(2014) François Coulombe et al.   IMMUNITY

PGE2 suppression of innate immunity during mucosal bacterial infection

(2013) Mallory Agard et al.   Frontiers in Cellular and Infection Microbiology

Influenza A Virus Induces Interleukin-27 through Cyclooxygenase-2 and Protein Kinase A Signaling

(2012) Li Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostaglandin E2 induces growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6)

(2012) Shahrzad Soleymani Fard et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Erythropoietin Preserves the Endothelial Differentiation Capacity of Cardiac Progenitor Cells and Reduces Heart Failure during Anticancer Therapies

(2011) Melanie Hoch et al.   Cell Stem Cell

Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

(2011) Stephen L Nutt et al.   NATURE IMMUNOLOGY

Effects of Flavonoids on Prostaglandin E2Production and on COX-2 and mPGES-1 Expressions in Activated Macrophages

(2011) Mari Hämäläinen et al.   PLANTA MEDICA

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE