A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: a dichotomy of expectation and reality

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Preventing a covid-19 pandemic

(2020) John Watkins   BMJ-British Medical Journal

Letter to the Editor: Angiotensin-converting enzyme 2: an ally or a Trojan horse? Implications to SARS-CoV-2-related cardiovascular complications

(2020) Zaid Abassi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry

(2020) Milena Gianfrancesco et al.   ANNALS OF THE RHEUMATIC DISEASES

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

The Science Underlying COVID-19: Implications for the Cardiovascular System

(2020) Peter P. Liu et al.   CIRCULATION

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

(2020) Xiaohua Chen et al.   CLINICAL INFECTIOUS DISEASES

Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

(2020) Daniel Batlle et al.   CLINICAL SCIENCE

Immune responses and pathogenesis of SARS‐CoV ‐2 during an outbreak in Iran: Comparison with SARS and MERS

(2020) Mohsen Rokni et al.   REVIEWS IN MEDICAL VIROLOGY

Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists

(2020) Michael Day   BMJ-British Medical Journal

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Antihypertensive drugs and risk of COVID-19? – Authors' reply

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women and Children

(2020) Elena Ciaglia et al.   Frontiers in Pediatrics

Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: A closer look at angiotensin-converting enzyme 2 (ACE2)

(2020) Annalise E Zemlin et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Gender Differences in Patients With COVID-19: Focus on Severity and Mortality

(2020) Jian-Min Jin et al.   Frontiers in Public Health

Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

(2020) Jiawei Chen et al.   AGING CELL

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

(2020) Rosanna Asselta et al.   Aging-US

Ibuprofen use and clinical outcomes in COVID-19 patients

(2020) E. Rinott et al.   CLINICAL MICROBIOLOGY AND INFECTION

Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID‐19 patients in Michigan, United States

(2020) Z. Imam et al.   JOURNAL OF INTERNAL MEDICINE

COVID-19: Melatonin as a potential adjuvant treatment

(2020) Rui Zhang et al.   LIFE SCIENCES

COVID-19 and risks to the supply and quality of tests, drugs, and vaccines

(2020) Paul N Newton et al.   Lancet Global Health

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

(2018) David Møbjerg Kristensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entropy drives the insertion of ibuprofen into model membranes

(2018) Natalia Rojas-Valencia et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

miRNA-200c-3p is crucial in acute respiratory distress syndrome

(2017) Qiang Liu et al.   Cell Discovery

Ibuprofen Attenuates Cardiac Fibrosis in Streptozotocin-Induced Diabetic Rats

(2015) Weili Qiao et al.   CARDIOLOGY

Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats

(2015) Hao Luo et al.   Cardiovascular Diabetology

NSAIDs: Learning new tricks from old drugs

(2015) Federico Díaz-González et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis

(2015) James F. Chmiel et al.   Journal of Cystic Fibrosis

Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs

(2015) Irene Ramos et al.   Frontiers in Immunology

Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases

(2014) Nirmal Parajuli et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis

(2013) AC Simões e Silva et al.   BRITISH JOURNAL OF PHARMACOLOGY

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial

(2013) L. Gallelli et al.   OSTEOARTHRITIS AND CARTILAGE

Enhanced Angiotensin II-Induced Cardiac and Aortic Remodeling in ACE2 Knockout Mice

(2012) Mahmoud S. Alghamri et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Sex-Specific Influence of Angiotensin Type 2 Receptor Stimulation on Renal Function

(2011) Lucinda M. Hilliard et al.   HYPERTENSION

Angiotensin-Converting Enzyme 2: The First Decade

(2011) Nicola E. Clarke et al.   International Journal of Hypertension

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation

(2009) Taina Sten et al.   STEROIDS

Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor

(2008) Rebecca A. Lew et al.   EXPERIMENTAL PHYSIOLOGY

Detection of Soluble Angiotensin-Converting Enzyme 2 in Heart Failure

(2008) Slava Epelman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY