Bergapten: A review of its pharmacology, pharmacokinetics, and toxicity

Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology of Cnidium monnieri (L.) Cusson

(2020) Yue Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii

(2020) Frederico Severino Martins et al.   PLANTA MEDICA

Furanocoumarins in anticancer therapy – For and against

(2020) Joanna Sumorek-Wiadro et al.   FITOTERAPIA

Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms

(2020) Joanna Kowalczyk et al.   Frontiers in Neuroscience

In Silico Studies and In Vivo MAOA Inhibitory Activity of Coumarins Isolated from Angelica archangelica Extract: An Approach toward Antidepressant Activity

(2020) Anudeep Kaur et al.   ACS Omega

Valuable products from the flowers of lemon (Citrus limon (L.) Osbeck) and grapefruit (Citrus paradisi Macfad.) Italian trees

(2020) V. Pellizzeri et al.   FOOD AND BIOPRODUCTS PROCESSING

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

Edge activated ultradeformable cationic liposomes of psoralen and its derivatives: Development and comparative evaluation for vitiligo therapy

(2019) Shaheen Mahira et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Methoxsalen and Bergapten Prevent Diabetes-Induced Osteoporosis by the Suppression of Osteoclastogenic Gene Expression in Mice

(2019) Ju Ham et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum , and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes

(2019) Gulmira Ozek et al.   CHEMISTRY & BIODIVERSITY

Bergapten Ameliorates Vincristine-Induced Peripheral Neuropathy by Inhibition of Inflammatory Cytokines and NFκB Signaling

(2019) Gurjit Singh et al.   ACS Chemical Neuroscience

Bergapten alleviates osteoarthritis by regulating the ANP 32A/ ATM signaling pathway

(2019) Yi He et al.   FEBS Open Bio

Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines

(2019) Gurjit Singh et al.   INFLAMMOPHARMACOLOGY

Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

(2019) Md. Farhad Hossain et al.   MOLECULAR NEUROBIOLOGY

Microemulsions incorporating Brosimum gaudichaudii extracts as a topical treatment for vitiligo: In vitro stimulation of melanocyte migration and pigmentation

(2019) Wanessa de Souza Cardoso Quintão et al.   JOURNAL OF MOLECULAR LIQUIDS

Identification of non-alkaloid natural compounds of Angelica purpurascens (Avé-Lall.) Gilli. (Apiaceae) with cholinesterase and carbonic anhydrase inhibition potential

(2019) Songul Karakaya et al.   SAUDI PHARMACEUTICAL JOURNAL

Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment

(2019) Yucheng Zhao et al.   Journal of Advanced Research

Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model

(2018) Yi Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Estrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer

(2018) B. Madhu Krishna et al.   BMC CANCER

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

(2018) Nava Zisapel   BRITISH JOURNAL OF PHARMACOLOGY

Cytochrome P450 Structure, Function and Clinical Significance: A Review

(2018) Palrasu Manikandan et al.   CURRENT DRUG TARGETS

Simultaneous Determination of Six Coumarins in Rat Plasma and Metabolites Identification of Bergapten in Vitro and in Vivo

(2018) Man Liao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative pharmacokinetics of six coumarins in normal and breast cancer bone-metastatic mice after oral administration of Wenshen Zhuanggu Formula

(2018) Weiling Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Distribution Assessments of Coumarins from Angelicae Pubescentis Radix in Rat Cerebrospinal Fluid and Brain by Liquid Chromatography Tandem Mass Spectrometry Analysis

(2018) et al.   MOLECULES

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

(2018) Filippo Caraci et al.   PHARMACOLOGICAL RESEARCH

Treating p53 Mutant Aggregation-Associated Cancer

(2018) Mathumai Kanapathipillai   Cancers

Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways

(2018) Shakti Prasad Pattanayak et al.   BIOMEDICINE & PHARMACOTHERAPY

Immuno Modulatory Effects of Bergapten Attenuates D-galactose-induced Aging Model in Balb/C Mice

(2018) Zhanxiong Xie et al.   International Journal of Pharmacology

Drug and chemical induced photosensitivity from a clinical perspective

(2018) Sally H Ibbotson   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells

(2018) Yu Zhang et al.   OncoTargets and Therapy

Bergapten induces G1 arrest and pro-apoptotic cascade in colorectal cancer cells associating with p53/p21/PTEN axis

(2018) Ching-Pin Lin et al.   ENVIRONMENTAL TOXICOLOGY

Dietary furocoumarins and skin cancer: A review of current biological evidence

(2018) Melissa M. Melough et al.   FOOD AND CHEMICAL TOXICOLOGY

Defined Small Molecules Produced by Himalayan Medicinal Plants Display Immunomodulatory Properties

(2018) Phurpa Wangchuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adaptive homeostasis of the vitamin D–vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity

(2018) Guolin Zhao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bergapten suppresses RANKL-induced osteoclastogenesis and ovariectomy-induced osteoporosis via suppression of NF-κB and JNK signaling pathways

(2018) Guiping Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Psoralen loaded liposomal nanocarriers for improved skin penetration and efficacy of topical PUVA in psoriasis

(2017) Sindhu Doppalapudi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Bergapten prevents lipopolysaccharide-induced inflammation in RAW264.7 cells through suppressing JAK/STAT activation and ROS production and increases the survival rate of mice after LPS challenge

(2017) Yi Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Osteoblast role in osteoarthritis pathogenesis

(2017) Nicola Maruotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Simultaneous assessment of absorption characteristics of coumarins from Angelicae Pubescentis Radix: In vitro transport across Caco-2 cell and in vivo pharmacokinetics in rats after oral administration

(2017) Yan-Fang Yang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis

(2017) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo

(2017) Sindhu Doppalapudi et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

α-Glucosidase inhibitory and antioxidant activity of furanocoumarins from Heracleum persicum

(2017) Hossein Dehghan et al.   MEDICINAL CHEMISTRY RESEARCH

Spectrum Effect Relationship and Component Knock-Out in Angelica Dahurica Radix by High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer

(2017) Jinmei Wang et al.   MOLECULES

Screening of fruits of seven plants indicated for medicinal use in Iraq

(2017) Omar Aldulaimi   Pharmacognosy Magazine

8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity

(2017) Guolin Zhao et al.   TOXICOLOGY

ABC-transporter blockage mediated by xanthotoxin and bergapten is the major pathway for chemosensitization of multidrug-resistant cancer cells

(2017) Seyed Abbas Mirzaei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

(2017) Dong Li et al.   Experimental and Therapeutic Medicine

The impact of type 2 diabetes on bone metabolism

(2017) Claudia Pinheiro Sanches et al.   Diabetology & Metabolic Syndrome

Rare Coumarins Induce Apoptosis, G1 Cell Block and Reduce RNA Content in HL60 Cells

(2017) Jarosław Widelski et al.   Open Chemistry

British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen-ultraviolet A therapy 2015

(2016) T.C. Ling et al.   BRITISH JOURNAL OF DERMATOLOGY

Inhibition of melatonin metabolism in humans induced by chemical components from herbs and effective prediction of this risk using a computational model

(2016) Chao Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection

(2016) Xie-an Yu et al.   Chemistry Central Journal

Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-α/PI3K/Akt-Signaling Pathways in HepG2 Cells

(2016) Ke Fang et al.   Evidence-based Complementary and Alternative Medicine

Ultraviolet irradiation promotesFOXP3transcription via p53 in psoriasis

(2016) Dongmei Zhang et al.   EXPERIMENTAL DERMATOLOGY

Development of a comprehensive analytical method for furanocoumarins in grapefruit and their metabolites in plasma and urine using UPLC-MS/MS: a preliminary study

(2016) Sang Gil Lee et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice

(2016) Xue-Ju Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cholinesterase, tyrosinase inhibitory and antioxidant potential of randomly selected Umbelliferous plant species and chromatographic profile of Heracleum platytaenium Boiss. and Angelica sylvestris L. var. sylvestris

(2016) Ilkay Orhan et al.   JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

In vitro antimicrobial and acetylcholinesterase inhibitory activities of coumarins from Ferulago carduchorum

(2016) Fereshteh Golfakhrabadi et al.   MEDICINAL CHEMISTRY RESEARCH

Implication of coumarins towards central nervous system disorders

(2016) Krystyna Skalicka-Woźniak et al.   PHARMACOLOGICAL RESEARCH

In vivo modulation of the behavioral effects of nicotine by the coumarins xanthotoxin, bergapten, and umbelliferone

(2016) Barbara Budzynska et al.   PSYCHOPHARMACOLOGY

Celery extract inhibits mouse CYP2A5 and human CYP2A6 activities via different mechanisms

(2016) Xiao Deng et al.   Oncology Letters

Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract

(2016) John Teye Azietaku et al.   International Journal of Analytical Chemistry

Psoralen and Bergapten: In Silico Metabolism and Toxicophoric Analysis of Drugs Used to Treat Vitiligo

(2016) Vinicius Barreto Da Silva et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Global Cancer Incidence and Mortality Rates and Trends--An Update

(2015) L. A. Torre et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Anti-inflammatory and antioxidant effects of coumarins isolated fromFoeniculum vulgarein lipopolysaccharide-stimulated macrophages and 12-O-tetradecanoylphorbol-13-acetate-stimulated mice

(2015) In Jun Yang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Bergapten promotes bone marrow stromal cell differentiation into osteoblasts in vitro and in vivo

(2015) Ji-jie Xiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells

(2015) Francesca De Amicis et al.   Molecular Cancer

Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer—An in Vitro Model for Blood-Brain Barrier Permeability

(2015) Yan-Fang Yang et al.   MOLECULES

Two nematicidal furocoumarins fromFicus caricaL. leaves and their physiological effects on pine wood nematode (Bursaphelenchus xylophilus)

(2015) Qunqun Guo et al.   NATURAL PRODUCT RESEARCH

Bergapten induces metabolic reprogramming in breast cancer cells

(2015) MARTA SANTORO et al.   ONCOLOGY REPORTS

Reduction in tissue plasmin: a new mechanism of action of narrowband ultraviolet B in psoriasis

(2014) D. Metwally et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development

(2014) Young Choi et al.   CURRENT PHARMACEUTICAL DESIGN

Application of Ionic Liquid-Based Ultrasound-Assisted Extraction of Five Phenolic Compounds from Fig (Ficus carica L.) for HPLC-UV

(2014) Hongying Qin et al.   Food Analytical Methods

Photochemotherapy (PUVA) in psoriasis and vitiligo

(2014) Smitha Prabhu et al.   Indian Journal of Dermatology Venereology & Leprology

Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography–tandem mass spectrometry

(2014) Jing Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Anticonvulsant effects of four linear furanocoumarins, bergapten, imperatorin, oxypeucedanin, and xanthotoxin, in the mouse maximal electroshock-induced seizure model: a comparative study

(2014) Jarogniew J. Łuszczki et al.   Pharmacological Reports

PreliminaryIn VitroandIn VivoEvaluation of Antidiabetic Activity ofDucrosia anethifoliaBoiss. and Its Linear Furanocoumarins

(2014) Nagwa M. M. Shalaby et al.   Biomed Research International

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Simultaneous and sensitive determination of eight coumarins in rat bile and urine after oral administration ofRadix Angelicae Dahuricaeextract by liquid chromatography-electrospray ionization-mass spectrometry

(2013) H. L. Huo et al.   ACTA CHROMATOGRAPHICA

Systematic Review of UV-Based Therapy for Psoriasis

(2013) Fahad Almutawa et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Bergapten prevents lipopolysaccharide mediated osteoclast formation, bone resorption and osteoclast survival

(2013) Mingxia Zheng et al.   INTERNATIONAL ORTHOPAEDICS

The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins

(2013) Taryn O׳Neill et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation

(2013) Maho Sumiyoshi et al.   Journal of Natural Medicines

Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, imperatorin, osthole and isoimperatorin in rat plasma by LC–MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract

(2013) Yan-xu Chang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Postmenopausal osteoporosis

(2013) Dima L. Diab et al.   Current Opinion in Endocrinology Diabetes and Obesity

Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination

(2012) M. L. Panno et al.   BREAST CANCER RESEARCH AND TREATMENT

Efficacy of psoralen plus ultraviolet A therapy vs. biologics in moderate to severe chronic plaque psoriasis: retrospective data analysis of a patient registry

(2011) M. Inzinger et al.   BRITISH JOURNAL OF DERMATOLOGY

Immunotoxicity activity of natural furocoumarins from milky sap ofFicus caricaL. againstAedes aegyptiL.

(2011) III-Min Chung et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

Effect of PUVA therapy on melanocytes and keratinocytes in non-segmental vitiligo: histopathological, immuno-histochemical and ultrastructural study

(2011) Tag S. Anbar et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

An in vitro and in silico approach to cholinesterase inhibitory and antioxidant effects of the methanol extract, furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits

(2011) Fatma Sezer Senol et al.   Phytochemistry Letters

Quantitative analysis of nine coumarins in rat urine and bile after oral administration of Radix Glehniae extract by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry

(2010) Man Liu et al.   BIOMEDICAL CHROMATOGRAPHY

Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation

(2010) Maria Luisa Panno et al.   FEBS LETTERS

Simultaneous and sensitive determination of xanthotoxin, psoralen, isoimpinellin and bergapten in rat plasma by liquid chromatography–electrospray ionization mass spectrometry

(2010) Wei Yang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells

(2010) Eunjin Shin et al.   Journal of Natural Medicines

In vitrophoto-induced cytotoxic activity ofCitrus bergamiaandC. medicaL. cv. Diamante peel essential oils and identified active coumarins

(2010) Federica Menichini et al.   PHARMACEUTICAL BIOLOGY

Caffeine as a photoprotective agent for diminishing phototoxicity

(2010) Yim Tong Szeto et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms

(2009) Joi A. Nichols et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Evidence that Bergapten, Independently of its Photoactivation, Enhances p53 Gene Expression and Induces Apoptosis in Human Breast Cancer Cells

(2009) M. Panno et al.   CURRENT CANCER DRUG TARGETS

Effect of bergapten fromHeracleum nepalenseroot on production of proinflammatory cytokines

(2009) Sekhar K. Bose et al.   NATURAL PRODUCT RESEARCH

Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium

(2007) F TOSUN et al.   FOOD CHEMISTRY