Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis

Paediatric drug development: The impact of evolving regulations

(2014) M.A. Turner et al.   ADVANCED DRUG DELIVERY REVIEWS

Automated Combustion Accelerator Mass Spectrometry for the Analysis of Biomedical Samples in the Low Attomole Range

(2014) Esther van Duijn et al.   ANALYTICAL CHEMISTRY

Population Pharmacokinetics of Ciprofloxacin in Neonates and Young Infants Less than Three Months of Age

(2014) Wei Zhao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept

(2014) Miriam G. Mooij et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetic analysis of14C-ursodiol in newborn infants using accelerator mass spectrometry

(2014) Toufigh Gordi et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Microdosing and drug development: past, present and future

(2013) Graham Lappin et al.   Expert Opinion on Drug Metabolism & Toxicology

Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults

(2013) Chenguang Wang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

(2012) R Leong et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Antibiotic dosing in children in Europe

(2012) Charlotte I.S. Barker et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Microdosing: A Critical Assessment of Human Data

(2012) Malcolm Rowland   JOURNAL OF PHARMACEUTICAL SCIENCES

European Bioanalysis Forum recommendation: scientific validation of quantification by accelerator mass spectrometry

(2012) David Higton et al.   Bioanalysis

A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry

(2011) R. A. Graham et al.   DRUG METABOLISM AND DISPOSITION

Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

(2011) Graham Lappin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Facilitating pharmacokinetic studies in children: a new use of dried blood spots

(2010) P. Patel et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Pharmacokinetics of fexofenadine: Evaluation of a microdose and assessment of absolute oral bioavailability

(2010) Graham Lappin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Development and validation of a dried blood spot—LC–APCI–MS assay for estimation of canrenone in paediatric samples

(2010) Maysa Faisal Suyagh et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Understanding the Relative Roles of Pharmacogenetics and Ontogeny in Pediatric Drug Development and Regulatory Science

(2010) J. Steven Leeder et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A generic biokinetic model for Carbon-14

(2010) R. P. Manger   RADIATION PROTECTION DOSIMETRY

Practical experience of using human microdosing with AMS analysis to obtain early human drug metabolism and PK data

(2010) R Colin Garner   Bioanalysis

A pharmacokinetic evaluation of five H1antagonists after an oral and intravenous microdose to human subjects

(2009) Ajay Madan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Improving Pediatric Dosing Through Pediatric Initiatives: What We Have Learned

(2008) W. Rodriguez et al.   PEDIATRICS

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS

The problems in scaling adult drug doses to children

(2007) T N Johnson   ARCHIVES OF DISEASE IN CHILDHOOD