Journal
BRITISH JOURNAL OF ANAESTHESIA
Volume 127, Issue 4, Pages 547-555Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bja.2021.06.046
Keywords
bleeding; cardiac surgery; ischaemia-reperfusion injury; nitric oxide; nitrate; nitrite; perioperative
Categories
Funding
- Swedish Research Council
- Swedish Heart and Lung Foundation
- Stockholm City Council (ALF)
- Karolinska Institutet, Stockholm, Sweden
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The preoperative administration of inorganic nitrate did not have an impact on the release of troponin T or other plasma biomarkers of organ injury in cardiac surgery, as seen in this study.
Background: Nitric oxide (NO) is an important signalling molecule in the cardiovascular system with protective properties in ischaemia-reperfusion injury. Inorganic nitrate, an oxidation product of endogenous NO production and a constituent in our diet, can be recycled back to bioactive NO. We investigated if preoperative administration of inorganic nitrate could reduce troponin T release and other plasma markers of injury to the heart, liver, kidney, and brain in patients undergoing cardiac surgery. Methods: This single-centre, randomised, double-blind, placebo-controlled trial included 82 patients undergoing coronary artery bypass surgery with cardiopulmonary bypass. Oral sodium nitrate (700 mgx2) or placebo (NaCl) were administered before surgery. Biomarkers of ischaemia-reperfusion injury and plasma nitrate and nitrite were collected before and up to 72 h after surgery. Troponin T release was our predefined primary endpoint and biomarkers of renal, liver, and brain injury were secondary endpoints. Results: Plasma concentrations of nitrate and nitrite were elevated in nitrate-treated patients compared with placebo. The 72-h release of troponin T did not differ between groups. Other plasma biomarkers of organ injury were also similar between groups. Blood loss was not a predefined outcome parameter, but perioperative bleeding was 18% less in nitrate treated patients compared with controls. Conclusion: Preoperative administration of inorganic nitrate did not influence troponin T release or other plasma biomarkers of organ injury in cardiac surgery.
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