Review
Clinical Neurology
Xiao Xu, Zoya Iqbal, Limei Xu, Caining Wen, Li Duan, Jiang Xia, Ningning Yang, Yuanmin Zhang, Yujie Liang
Summary: Extracellular vesicles (EVs) have the potential to serve as biomarkers for the diagnosis of brain diseases. However, the lack of sensitive methods for isolating and detecting these EVs has been a challenge. This review highlights recent findings on exosomal biomarkers and discusses highly sensitive sensors and state-of-the-art methods for EV detection. The development of advanced EV analysis approaches for non-invasive diagnosis of brain diseases is also discussed.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Neurosciences
Yadaly Gassama, Alexandre Favereaux
Summary: Extracellular vesicles play a crucial role in intercellular communication, especially in the central nervous system, and may serve as important biomarkers and therapeutic agents in clinical research in the future.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Jared Mattingly, Yuchen Li, Ji C. Bihl, Jinju Wang
Summary: Exosomes, secreted by various types of cells, play a crucial role in cell-to-cell communication by delivering proteins and nucleic acids. They are increasingly recognized for their involvement in the pathogenesis of central nervous system diseases and as a promising therapeutic strategy. Research has shown that exosome infusion has beneficial effects on CNS injury animal models, highlighting their potential in neurological medicine.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Zhimin Yang, Yanyu Li, Zihua Wang
Summary: Exosomes are important communication carriers between cells and can be used for disease diagnosis and treatment. MSCs-Exo, as a natural drug delivery carrier, has therapeutic effects and is increasingly used in the treatment of cardiovascular diseases and neurodegenerative diseases.
Review
Cell Biology
Zhiyuan Ning, Ying Liu, Daji Guo, Wei-Jye Lin, Yamei Tang
Summary: This article reviews the basic knowledge of NK cell biology and recent advances in their roles in the healthy CNS and pathological conditions. The authors highlight the interactions between NK cells and diverse cell types in the CNS, as well as the potential value of NK cells as novel therapeutic targets for CNS diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Cell Biology
Margarida Beatriz, Rita Vilaca, Carla Lopes
Summary: Extracellular vesicles (EVs) are nano-sized particles released by cells that facilitate intercellular communication by transferring biological material. Recent studies suggest that exosomes, a type of EV, play a crucial role in the spread of neurodegenerative diseases by carrying genetic material and proteins. This review focuses on the role of exosomes in central nervous system homeostasis, their potential contribution to neurodegenerative diseases, the use of exosome cargo as disease biomarkers, and the benefits of circulating CNS-derived exosomes in plasma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Caterina Allegretta, Emanuele D'Amico, Virginia Manuti, Carlo Avolio, Massimo Conese
Summary: Autoimmune demyelinating diseases are a heterogeneous group of diseases characterized by neuroinflammation and loss of myelin. Mesenchymal stem cells (MSCs) have the potential to treat these diseases due to the anti-inflammatory and neuroprotective molecules in their secretome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Yishu Fan, Zhuohui Chen, Mengqi Zhang
Summary: Exosomes, cell-derived extracellular vesicles, have been found to play a significant role in the pathogenesis and potential treatment of CNS diseases, by transferring biologically active molecules between different cells and delivering drugs across the blood brain barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Mohaddeseh Hedayat, Mahdi Ahmadi, Maryam Shoaran, Jafar Rezaie
Summary: Despite advances in emerging therapies, effective treatment for neurodegenerative diseases remains urgent. MSCs-derived exosomes (MSCs-Exo) hold promise as a novel therapy for neurodegenerative diseases due to their ability to infiltrate the blood-brain barrier and deliver non-coding RNAs to injured tissues. Non-coding RNAs of MSCs-Exo play a vital role in neurodegenerative disease treatment through neurogeneration, immune modulation, neuroinflammation reduction, tissue repair, and neuroangiogenesis promotion. This review summarizes the therapeutic role of non-coding RNAs of MSCs-Exo and discusses their potential as a drug delivery system and the challenges and opportunities for clinical translation in the future.
Review
Neurosciences
Luyao Huo, Xinzhe Du, Xinrong Li, Sha Liu, Yong Xu
Summary: Exosomes play a crucial role in intercellular communication in the central nervous system, regulating cellular function and contributing to both health and neurodegenerative diseases.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Wenyue Li, Junwei Cheng, Fangfei He, Peisen Zhang, Ni Zhang, Jian Wang, Qiliang Song, Yi Hou, Zhihua Gan
Summary: Central nervous system (CNS) diseases are a major global health concern with serious impacts on human health. It is estimated that there will be about 135 million cases of CNS diseases worldwide by mid-century, making it the second leading cause of death after cardiovascular diseases by 2040. The delivery of theranostic agents is hampered by the biological barrier, leading to a lack of effective diagnostic and therapeutic strategies for most CNS diseases. Recent advancements in nanotechnology-based drug delivery offer promising solutions, particularly cell membrane-based nanomaterials with natural bio-surface, high biocompatibility, and biosafety. This review provides an overview of the fabrication of cell membrane-based nanomaterials, summaries of different CNS diseases and the application of cell membrane-based nanomaterials in theranostics, as well as future prospects and limitations of cell membrane nanotechnology.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Claudia Garcia-Rodriguez, Paula Mujica, Javiera Illanes-Gonzalez, Araceli Lopez, Camilo Vargas, Juan C. Saez, Arlek Gonzalez-Jamett, Alvaro O. Ardiles
Summary: Probenecid, an old uricosuric agent, has been used to treat gout and reduce renal excretion of antibiotics. Recent studies have shown that Probenecid has the ability to interact with membrane proteins, indicating potential therapeutic applications in medicine. It has been found to have neuroprotective, antiepileptic, and anti-inflammatory properties, making it useful in the treatment of neurological and neurodegenerative diseases. Despite its declining clinical use, Probenecid shows promise in preclinical research as a strategy to enhance drug bioavailability in the central nervous system.
Article
Biochemistry & Molecular Biology
Gonzalo Garcia-Martin, Miriam Sanz-Rodriguez, Berta Alcover-Sanchez, Marta P. Pereira, Francisco Wandosell, Beatriz Cubelos
Summary: The optic nerve, being highly myelinated, is susceptible to myelin diseases that affect the visual system. R-Ras1 and R-Ras2 have been identified as crucial for the survival and maturation of oligodendrocytes, and their absence leads to hypomyelination and loss of visual and motor function. Furthermore, R-Ras1 and R-Ras2 are found to be more abundant in less-myelinated areas of the central nervous system, and R-Ras2 is specifically expressed in neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Qingqing Zhang, Qinghua Jiang, Kuiru Sa, Junming Liang, Dejuan Sun, Hua Li, Lixia Chen
Summary: Central nervous system (CNS) disease is a leading cause of human death, and drug treatment is the main approach. However, most drugs only provide symptom relief and may have toxicity and side effects. Natural alkaloids derived from plants offer safer and more effective alternatives. This review summarizes 120 alkaloids with potential effects in treating CNS diseases, including their sources, structure types, mechanism of action, and structure-activity relationship.
PHYTOTHERAPY RESEARCH
(2023)
Review
Medicine, Research & Experimental
Majid Babaei, Jafar Rezaie
Summary: Ischemic diseases, characterized by insufficient blood flow leading to decreased oxygen and nutrient uptake, are a significant global contributor to disability and mortality. Up-regulation of angiogenesis, particularly through stem cell-derived exosomes, shows promise in treating these diseases by promoting blood vessel formation. Further research is needed to address limitations in exosome isolation and application, and to effectively translate preclinical findings into clinical practice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Wenshu Li, Wei Zhang, Huishan Zhao, Yongli Chu, Xuemei Liu
Summary: The depot GnRH agonist protocol showed significantly higher cumulative clinical pregnancy rates and cumulative live birth rates compared to mild ovarian stimulation protocol and GnRH antagonist protocol. Women who received the depot GnRH agonist had higher stimulation duration, total dose of gonadotropins, and endometrial thickness, as well as lower embryo transfer cancellation rate and abnormal endometrium rate.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Genetics & Heredity
Jingyu Li, Chong Li, Xuemei Liu, Jingwei Yang, Qi Zhang, Wei Han, Guoning Huang
Summary: The study evaluated the association between GDF9 concentration in human embryo culture medium and embryo quality and viability. Results showed that GDF9 concentration was linked to embryo quality and viability, suggesting it could serve as a non-invasive biomarker for embryo selection.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Kai Wan, Ye Yu, Chunqiao Xiao, Jinggang Hu, Xuemei Liu, Xiangyi Deng, Ruan Chi
Summary: Ammonia-nitrogen wastewater generated during rare-earth mining poses a serious threat to the surrounding environment. Conventional biological methods are ineffective in treating this type of wastewater. Anaerobic ammonia oxidation (anammox) has become the preferred method for treating rare earth mine wastewater. However, the impact of rare earth elements (REEs) on anammox bacteria has not been sufficiently studied, which limits its application.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Chen Fu, Yifan Wu, Shaojiao Liu, Chaoqin Luo, Yuqiao Lu, Menghan Liu, Lingfeng Wang, Yunling Zhang, Xuemei Liu
Summary: This study aims to investigate the effect of Rehmannioside A on cognitive impairment after ischemia in rats and SH-SY5Y cells, and further evaluate the anti-oxidative and anti-ferroptosis mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Physiology
Zhenteng Liu, Xuemei Liu, Meimei Wang, Huishan Zhao, Shunzhi He, Shoucui Lai, Qinglan Qu, Xinrong Wang, Dongmei Zhao, Hongchu Bao
Summary: The study evaluated the prevalence of WOI displacement in infertile women and the impact of ERA testing on IVF/ICSI outcomes. It found that approximately one third of infertile women could have WOI displacement, and ERA testing significantly increases the chances of successful pregnancy in non-receptive patients with RIF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Respiratory System
Zhiying Zhao, Wenyan Wang, Jing Jin, Xuemei Liu
Summary: This study found a higher readmission rate in elderly patients with acute decompensated heart failure. Pneumonia was listed as the top diagnosis for longer hospital stays in different departments. Patients readmitted with pneumonia may benefit from the geriatric department.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Huayu Sun, Hong Wang, Xuemei Liu, Ziyang Zhang, Siran Zhang, Xitao Wang, Yuan Liu
Summary: In order to improve the low-temperature activity and anti-sintering ability of Ni-based catalyst for CO2 methanation, nickel catalysts supported on ZrO2, CeO2, and Ce-Zr-O solid solutions were prepared and characterized. The results showed that the Ni/Ce0.2Zr0.8O2 catalyst exhibited the highest CO2 conversion and stability, which can be attributed to the high dispersion of active metal nickel and its small particle size, as well as the optimized interaction between Ce-Zr-O solid solution and Ni.
Article
Integrative & Complementary Medicine
Xuemei Liu, Tao Fan, Jinshuai Guan, Ai Luo, Yan Yu, Daohong Chen, Bing Mao, Hongli Jiang, Wei Liu
Summary: Electroacupuncture (EA) at ST36 can alleviate inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) through the dopamine D2 receptor pathway.
ACUPUNCTURE IN MEDICINE
(2023)
Article
Obstetrics & Gynecology
Xiuzhu Wang, Wenshu Li, Xuemei Chen, Wei Zhang, Min Chu, Shuyuan Yin, Yongli Chu, Xuemei Liu
Summary: The long-acting GnRH agonist long protocol improves IVF outcomes in patients with endometriosis, leading to higher clinical pregnancy rate, implantation rate, and live birth rate. This protocol also requires longer duration of stimulation, higher total dose of gonadotropin, and more high-quality embryos transferred.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Plant Sciences
Xuemei Liu, Yan Yu, Yanqing Wu, Ai Luo, Mei Yang, Ting Li, Tingqian Li, Bing Mao, Xiaoting Chen, Juanjuan Fu, Hongli Jiang, Wei Liu
Summary: This study investigated the pharmacological mechanism of Yupingfeng (YPF) in the treatment of asthma. The results demonstrated that YPF and its active compound wogonin may exert therapeutic effects on asthma inflammation through multiple molecular targets and signaling pathways including PI3K/AKT, IL-17, and TNF-alpha.
Article
Microbiology
Xuemei Liu, Ziqi Cheng, Guohao Xu, Jiemin Xie, Xudong Liu, Bozhen Ren, Dongmei Ai, Yangxin Chen, Li Charlie Xia
Summary: In this paper, a novel high-throughput tool called Ksak is introduced for alignment-free phylogenetic analysis. Ksak computes pairwise distance matrix using seven widely accepted k-mer based distance measures and constructs the phylogenetic tree with standard algorithms. Benchmarking results show that Ksak is the most accurate tool among five compared tools, outperforming ClustalW2, a high-accuracy multiple sequence aligner, by 19%. Moreover, Ksak is tens to hundreds of times faster than ClustalW2, addressing the computation limit in large-scale multiple sequence alignment. Ksak is freely available.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Youde Ding, Yuan Liao, Ji He, Jianfeng Ma, Xu Wei, Xuemei Liu, Guiying Zhang, Jing Wang
Summary: This paper proposes a compression algorithm (CA_SAGM) based on the characteristics of sparse genomic mutation data, which compresses the data into sparse row format (CSR) by sorting the data row-first and renumbering them using the reverse Cuthill-Mckee sorting technique. Experimental results show that CA_SAGM performs the best in terms of compression and decompression time, COO method has the best compression performance, and CSC method has the worst performance. As the sparsity increases, all three algorithms show longer compression and decompression times, lower compression and decompression rates, larger compression memory, and lower compression ratios.
FRONTIERS IN GENETICS
(2023)
Article
Obstetrics & Gynecology
Xuemei Chen, Wei Zhang, Yanping Xu, Wenshu Li, Xiuzhu Wang, Shulei Shi, Xuemei Liu
Summary: The long-acting GnRHa long protocol improves the outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) for patients with repeated implantation failure (RIF), leading to higher clinical pregnancy rates, implantation rates, and live birth rates. It also enhances the expression of HOXA10 in endometrial tissues.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Physics, Multidisciplinary
Yang Rui, Liang Zhang, Rui Li, Xuemei Liu, Chunyang Duan, Pengyue Liu, Yuelong Wu, Haibin Wu
Summary: We report the first realization of cold atom interferometers using 6Li, the lightest alkali metal, and measure the recoil frequency with great precision. By cooling the atoms using a narrow 2S -> 3P ultraviolet transition, we approach half of the photon-recoil limit. We overcome the challenges of half-integer spin and hyperfine interaction by developing a magnetically insensitive state, a high-efficiency state preparation, and a frequency-insensitive Raman coupling. A Conjugated Ramsey-Borde interferometer with crossed Raman beams is realized, and the measured recoil frequency represents the most precise measurement so far using an atom interferometer.
PHYSICAL REVIEW RESEARCH
(2023)
Article
Physics, Multidisciplinary
Liu Xue-Mei, Rui Yang, Zhang Liang, Wu Yue-Long, Wu Hai-Bin
Summary: In this paper, a magnetic field locking system is used to achieve precise and stable control of the Feshbach magnetic field in ultracold atomic gas experiments. The feedback locking system effectively suppresses magnetic field noise and improves the stability of the ultracold atomic system. This system is of great significance for extending quantum storage time, controlling atomic scattering, and simulating condensed matter in experiments.
ACTA PHYSICA SINICA
(2022)
