ROS1fusions in cancer: a review

Molecular Characterization of Inflammatory Myofibroblastic Tumors With Frequent ALK and ROS1 Gene Fusions and Rare Novel RET Rearrangement

(2015) Cristina R. Antonescu et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Oncogenic TPM3-ALK activation requires dimerization through the coiled-coil structure of TPM3

(2015) Yosuke Amano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

(2015) Ramona Crescenzo et al.   CANCER CELL

Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKCα Activity under Mechanical Stimulation on the Elastomeric Substrates

(2015) Chun-Ping Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer

(2015) A. Song et al.   CLINICAL CANCER RESEARCH

ROS1 Immunohistochemistry Among Major Genotypes of Non–Small-Cell Lung Cancer

(2015) Theresa A. Boyle et al.   Clinical Lung Cancer

Geographic/ethnic variability of chromosomal and molecular abnormalities in leukemia

(2015) Marc De Braekeleer et al.   Expert Review of Anticancer Therapy

Crizotinib Therapy for Advanced Lung Adenocarcinoma and a ROS1 Rearrangement: Results From the EUROS1 Cohort

(2015) Julien Mazières et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparison of Methods in the Detection of ALK and ROS1 Rearrangements in Lung Cancer

(2015) Toni-Maree Rogers et al.   Journal of Thoracic Oncology

Searching for ROS1 Rearrangements in Lung Cancer by Fluorescent In Situ Hybridization: The Importance of Probe Design

(2015) Arnaud Uguen et al.   Journal of Thoracic Oncology

Identification of a novel TMEM106B-ROS1 fusion variant in lung adenocarcinoma by comprehensive genomic profiling

(2015) Sai-Hong Ignatius Ou et al.   LUNG CANCER

Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors

(2015) Jason L Hornick et al.   MODERN PATHOLOGY

MYC Alterations in Diffuse Large B-Cell Lymphomas

(2015) Kennosuke Karube et al.   SEMINARS IN HEMATOLOGY

Activation of RAS family members confers resistance to ROS1 targeting drugs

(2015) Marilisa Cargnelutti et al.   Oncotarget

ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability

(2015) Matthias Scheffler et al.   Oncotarget

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

(2015) Kathryn G. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of ROS1 Gene Rearrangement in Lung Adenocarcinoma: Comparison of IHC, FISH and Real-Time RT-PCR

(2015) Ling Shan et al.   PLoS One

Multiplex genomic profiling of non–small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study

(2015) Isamu Okamoto et al.   Oncotarget

Cabozantinib Overcomes Crizotinib Resistance in ROS1 Fusion-Positive Cancer

(2014) R. Katayama et al.   CLINICAL CANCER RESEARCH

Screening for theFIG-ROS1fusion in biliary tract carcinomas by nested PCR

(2014) Caterina Peraldo Neia et al.   GENES CHROMOSOMES & CANCER

Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma

(2014) X. Wang et al.   GENETICS AND MOLECULAR RESEARCH

ROS1expression and translocations in non-small-cell lung cancer: clinicopathological analysis of 1478 cases

(2014) Arne Warth et al.   HISTOPATHOLOGY

Adult-onset inflammatory myofibroblastic tumour of the stomach with aTFG-ROS1fusion

(2014) Hiromi Fujita et al.   HISTOPATHOLOGY

Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma

(2014) Rondell P. Graham et al.   HUMAN PATHOLOGY

Aggressive Behavior and Poor Prognosis of Endometrial Stromal Sarcomas With YWHAE-FAM22 Rearrangement Indicate the Clinical Importance to Recognize This Subset

(2014) Arnold-Jan Kruse et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Liprin- 1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration

(2014) V. Astro et al.   JOURNAL OF CELL SCIENCE

Clinical and the Prognostic Characteristics of Lung Adenocarcinoma Patients with ROS1 Fusion in Comparison with Other Driver Mutations in East Asian Populations

(2014) Yen-Fu Chen et al.   Journal of Thoracic Oncology

Clinical and prognostic implications of ALK and ROS1 rearrangements in never-smokers with surgically resected lung adenocarcinoma

(2014) Min Hwan Kim et al.   LUNG CANCER

ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: A comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features

(2014) Yunjian Pan et al.   LUNG CANCER

Comprehensive analysis of RET and ROS1 rearrangement in lung adenocarcinoma

(2014) Seung Eun Lee et al.   MODERN PATHOLOGY

Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B

(2014) Massimiliano Stagi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition

(2014) Elena Ardini et al.   Molecular Oncology

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer

(2014) Alice T. Shaw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure and function of the nucleosome-binding PWWP domain

(2014) Su Qin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Kinase fusions are frequent in Spitz tumours and spitzoid melanomas

(2014) Thomas Wiesner et al.   Nature Communications

Inflammatory Myofibroblastic Tumors Harbor Multiple Potentially Actionable Kinase Fusions

(2014) C. M. Lovly et al.   Cancer Discovery

ROS1-Rearranged Lung Cancer

(2013) Akihiko Yoshida et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

ROS1 Immunohistochemistry for Detection of ROS1-Rearranged Lung Adenocarcinomas

(2013) Lynette M. Sholl et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma

(2013) H. R. Kim et al.   ANNALS OF ONCOLOGY

ROS1 fusions in Chinese patients with non-small-cell lung cancer

(2013) W. Cai et al.   ANNALS OF ONCOLOGY

Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors

(2013) Stefania Staibano et al.   BMC CANCER

Identification ofROS1rearrangement in gastric adenocarcinoma

(2013) Jeeyun Lee et al.   CANCER

CLTC-ALKfusion as a primary event in congenital blastic plasmacytoid dendritic cell neoplasm

(2013) Kiriko Tokuda et al.   GENES CHROMOSOMES & CANCER

Syndecan-4 signaling at a glance

(2013) A. Elfenbein et al.   JOURNAL OF CELL SCIENCE

Shootin1 Acts in Concert with KIF20B to Promote Polarization of Migrating Neurons

(2013) T. Sapir et al.   JOURNAL OF NEUROSCIENCE

Identification of recurrentFGFR3fusion genes in lung cancer through kinome-centred RNA sequencing

(2013) Ian J Majewski et al.   JOURNAL OF PATHOLOGY

Clinicopathologic Analysis of ROS1-Rearranged Non–Small-Cell Lung Cancer and Proposal of a Diagnostic Algorithm

(2013) Heounjeong Go et al.   Journal of Thoracic Oncology

On the relevance of a testing algorithm for the detection of ROS1-rearranged lung adenocarcinomas

(2013) Lénaïg Mescam-Mancini et al.   LUNG CANCER

Immunohistochemical detection of ROS1 is useful for identifying ROS1 rearrangements in lung cancers

(2013) Akihiko Yoshida et al.   MODERN PATHOLOGY

ROS1 and ALK Fusions in Colorectal Cancer, with Evidence of Intratumoral Heterogeneity for Molecular Drivers

(2013) Dara L. Aisner et al.   MOLECULAR CANCER RESEARCH

The functional interactome landscape of the human histone deacetylase family

(2013) P. Joshi et al.   Molecular Systems Biology

Acquired Resistance to Crizotinib from a Mutation in CD74–ROS1

(2013) Mark M. Awad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel Targets in Non-Small Cell Lung Cancer: ROS1 and RET Fusions

(2013) J. F. Gainor et al.   ONCOLOGIST

Mouse Model for ROS1-Rearranged Lung Cancer

(2013) Yasuhito Arai et al.   PLoS One

Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-Small Cell Lung Cancer

(2013) Kurtis D. Davies et al.   PLoS One

Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

(2013) Ramesh Narayanan et al.   PLoS One

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

(2013) M. A. Davare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells

(2013) T C Izidoro-Toledo et al.   Cell Death & Disease

Breakpoint Analysis of Transcriptional and Genomic Profiles Uncovers Novel Gene Fusions Spanning Multiple Human Cancer Types

(2013) Craig P. Giacomini et al.   PLoS Genetics

ROS1 Receptor Tyrosine Kinase, a Druggable Target, is Frequently Overexpressed in Non-Small Cell Lung Carcinomas Via Genetic and Epigenetic Mechanisms

(2012) Hee Jin Lee et al.   ANNALS OF SURGICAL ONCOLOGY

The Oncogenic Lung Cancer Fusion Kinase CD74-ROS Activates a Novel Invasiveness Pathway through E-Syt1 Phosphorylation

(2012) H. J. Jun et al.   CANCER RESEARCH

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

(2012) Ramaswamy Govindan et al.   CELL

Hierarchy between the transmembrane and cytoplasmic domains in the regulation of syndecan-4 functions

(2012) Youngsil Choi et al.   CELLULAR SIGNALLING

The Use of Quantitative Real-Time Reverse Transcriptase PCR for 5' and 3' Portions of ALK Transcripts to Detect ALK Rearrangements in Lung Cancers

(2012) R. Wang et al.   CLINICAL CANCER RESEARCH

Identifying and Targeting ROS1 Gene Fusions in Non-Small Cell Lung Cancer

(2012) K. D. Davies et al.   CLINICAL CANCER RESEARCH

Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non-Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion

(2012) V. M. Rimkunas et al.   CLINICAL CANCER RESEARCH

Identification of KIF5B-RET and GOPC-ROS1 Fusions in Lung Adenocarcinomas through a Comprehensive mRNA-Based Screen for Tyrosine Kinase Fusions

(2012) Y. Suehara et al.   CLINICAL CANCER RESEARCH

Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene

(2012) Ken Dutton-Regester et al.   GENES CHROMOSOMES & CANCER

The transcriptional landscape and mutational profile of lung adenocarcinoma

(2012) J.-S. Seo et al.   GENOME RESEARCH

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function

(2012) Owen A. Brady et al.   HUMAN MOLECULAR GENETICS

Membrane Orientation and Subcellular Localization of Transmembrane Protein 106B (TMEM106B), a Major Risk Factor for Frontotemporal Lobar Degeneration

(2012) Christina M. Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition

(2012) Shumin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RETFusions Define a Unique Molecular and Clinicopathologic Subtype of Non–Small-Cell Lung Cancer

(2012) Rui Wang et al.   JOURNAL OF CLINICAL ONCOLOGY

ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers

(2012) Kristin Bergethon et al.   JOURNAL OF CLINICAL ONCOLOGY

Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney

(2012) Elaine O'Meara et al.   JOURNAL OF PATHOLOGY

Identification of CCDC6-RET Fusion in the Human Lung Adenocarcinoma Cell Line, LC-2/ad

(2012) Daisuke Matsubara et al.   Journal of Thoracic Oncology

RET, ROS1 and ALK fusions in lung cancer

(2012) Kengo Takeuchi et al.   NATURE MEDICINE

Loss of CCDC6 Affects Cell Cycle through Impaired Intra-S-Phase Checkpoint Control

(2012) Angeliki Thanasopoulou et al.   PLoS One

14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma

(2012) C.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulmonary Inflammatory Myofibroblastic Tumor Expressing a Novel Fusion, PPFIBP1-ALK: Reappraisal of Anti-ALK Immunohistochemistry as a Tool for Novel ALK Fusion Identification

(2011) K. Takeuchi et al.   CLINICAL CANCER RESEARCH

Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm

(2011) Juliann Chmielecki et al.   GENES CHROMOSOMES & CANCER

ALK-positive extramedullary plasmacytoma with expression of the CLTC-ALK fusion transcript

(2011) Wei-ya Wang et al.   PATHOLOGY RESEARCH AND PRACTICE

Survey of Tyrosine Kinase Signaling Reveals ROS Kinase Fusions in Human Cholangiocarcinoma

(2011) Ting-Lei Gu et al.   PLoS One

Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers

(2011) Chenguang Li et al.   PLoS One

Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis

(2010) Dingding Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

14-3-3epsiloncontributes to tumour suppression in laryngeal carcinoma by affecting apoptosis and invasion

(2010) Xing-Hua Che et al.   BMC CANCER

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth

(2010) Josette Carnahan et al.   MOLECULAR CANCER THERAPEUTICS

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

(2010) Eunice L. Kwak et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer

(2010) Juliann Chmielecki et al.   NUCLEIC ACIDS RESEARCH

CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1

(2010) V Leone et al.   ONCOGENE

Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB Fusion

(2010) Zhipeng Li et al.   PEDIATRIC BLOOD & CANCER

Anaplastic lymphoma kinase: signalling in development and disease

(2009) Ruth H. Palmer et al.   BIOCHEMICAL JOURNAL

Inhibition of LRIG3 gene expression via RNA interference modulates the proliferation, cell cycle, cell apoptosis, adhesion and invasion of glioblastoma cell (GL15)

(2009) Mingjun Cai et al.   CANCER LETTERS

Structural and mechanistic insights into microtubule end-binding proteins

(2009) Kevin C Slep   CURRENT OPINION IN CELL BIOLOGY

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth

(2008) Tadayuki Shimada et al.   JOURNAL OF CELL BIOLOGY