Chemical philanthropy: a path forward for antibiotic discovery?

Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli

(2016) Laurent Poirel et al.   LANCET INFECTIOUS DISEASES

Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids

(2016) Marisa Haenni et al.   LANCET INFECTIOUS DISEASES

Colistin resistance gene mcr-1 and pHNSHP45 plasmid in human isolates of Escherichia coli and Klebsiella pneumoniae

(2016) Nicole Stoesser et al.   LANCET INFECTIOUS DISEASES

Investigation of a plasmid genome database for colistin-resistance gene mcr-1

(2016) Satowa Suzuki et al.   LANCET INFECTIOUS DISEASES

Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany

(2016) Linda Falgenhauer et al.   LANCET INFECTIOUS DISEASES

Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam

(2016) Surbhi Malhotra-Kumar et al.   LANCET INFECTIOUS DISEASES

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Assembly and clustering of natural antibiotics guides target identification

(2016) Chad W Johnston et al.   Nature Chemical Biology

The Chemical Space Project

(2015) Jean-Louis Reymond   ACCOUNTS OF CHEMICAL RESEARCH

Thinking Outside the “Bug”: A Unique Assay To Measure Intracellular Drug Penetration in Gram-Negative Bacteria

(2015) Ying Zhou et al.   ANALYTICAL CHEMISTRY

Detection ofmcr-1encoding plasmid-mediated colistin-resistantEscherichia coliisolates from human bloodstream infection and imported chicken meat, Denmark 2015

(2015) Henrik Hasman et al.   Eurosurveillance

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets

(2015) Bradley C. Doak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

A community-based approach to new antibiotic discovery

(2015) Matthew A. Cooper   NATURE REVIEWS DRUG DISCOVERY

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

Global trends in antimicrobial use in food animals

(2015) Thomas P. Van Boeckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigational Agents for the Treatment of Gram-Negative Bacterial Infections: A Reality Check

(2015) Karen Bush   ACS Infectious Diseases

Helping Chemists Discover New Antibiotics

(2015) Mark A. T. Blaskovich et al.   ACS Infectious Diseases

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Scaffold diversity of natural products: inspiration for combinatorial library design

(2008) Kristina Grabowski et al.   NATURAL PRODUCT REPORTS