Journal
PHARMACOTHERAPY
Volume 32, Issue 8, Pages 707-721Publisher
WILEY-BLACKWELL
DOI: 10.1002/j.1875-9114.2012.01157.x
Keywords
prolonged infusions; dose optimization; pharmacokinetic; pharmacodynamics antimicrobial stewardship
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The optimal dosage and administration of antibiotics are not only important measures to combat antimicrobial resistance, but they are also integral to antimicrobial stewardship. In light of a diminishing antibiotic pipeline and an alarming rise in resistance, the optimal dosage and administration of antimicrobial agents have been under a great deal of scrutiny. Prolonged infusions of beta-lactam antibiotics have been proposed as an alternate dosing strategy. To summarize the evidence on prolonged infusions of beta-lactam agents and provide their clinical implications for antimicrobial stewardship, we performed a MEDLINE search (19502011) of all relevant articles. This article provides a review of data from Monte Carlo simulations, clinical outcome analyses, and pharmacoeconomic studies. Furthermore, protocol implementation strategies are discussed to address antimicrobial stewardship.
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