Shifting the paradigms for tumor suppression: lessons from the p53 field

The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma

(2021) Bruna R. Muys et al.   GENES & DEVELOPMENT

Targeting a neoantigen derived from a common TP53 mutation

(2021) Emily Han-Chung Hsiue et al.   SCIENCE

p53, cancer and the immune response

(2020) Julianna Blagih et al.   JOURNAL OF CELL SCIENCE

Pan-cancer analysis of whole genomes

(2020)   NATURE

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

(2020) Julianna Blagih et al.   Cell Reports

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

(2020) Eliran Kadosh et al.   NATURE

A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors

(2020) Thibaut Barnoud et al.   CANCER RESEARCH

p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen

(2020) Liz J. Valente et al.   JOURNAL OF CELL BIOLOGY

Tumor cells containing the African-Centric S47 variant of TP53 show increased Warburg metabolism

(2019) Thibaut Barnoud et al.   Oncotarget

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

(2019) Julia I-Ju Leu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

(2019) Steffen Boettcher et al.   SCIENCE

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

TP53,STK11andEGFRMutations Predict Tumor Immune Profile and the Response to anti-PD-1 in Lung Adenocarcinoma

(2018) Jerome Biton et al.   CLINICAL CANCER RESEARCH

Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics

(2018) Xin Yu et al.   CLINICAL CANCER RESEARCH

The tumor suppressor protein p53 and the ferroptosis network

(2018) Rui Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target

(2018) Ramona Schulz-Heddergott et al.   Cancers

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

(2018) Ramona Schulz-Heddergott et al.   CANCER CELL

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

Selective Pressures on Human Cancer Genes along the Evolution of Mammals

(2018) Alberto Vicens et al.   Genes

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma

(2016) Zhong-Yi Dong et al.   CLINICAL CANCER RESEARCH

An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

(2016) Matthew Jennis et al.   GENES & DEVELOPMENT

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Autophagy and p53

(2016) Eileen White   Cold Spring Harbor Perspectives in Medicine

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

(2016) Jiandong Chen   Cold Spring Harbor Perspectives in Medicine

p53 in the DNA-Damage-Repair Process

(2016) Ashley B. Williams et al.   Cold Spring Harbor Perspectives in Medicine

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Increased Oxidative Metabolism in the Li–Fraumeni Syndrome

(2013) Ping-Yuan Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

(2011) D. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keeping p53 in Check: A High-Stakes Balancing Act

(2010) Shelley L. Berger   CELL

The relevance of protein-protein interactions for p53 function: the CPE contribution

(2010) M. R. Fernandez-Fernandez et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Functions of p53 in metabolism and invasion:

(2009) Karen H. Vousden   BIOCHEMICAL SOCIETY TRANSACTIONS

Transcription-independent p53 apoptosis: an alternative route to death

(2009) Daniel Speidel   TRENDS IN CELL BIOLOGY

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

(2008) F. M. Boeckler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA