MRI of healthy brain aging: A review

Measuring compartmental T2-orientational dependence in human brain white matter using a tiltable RF coil and diffusion-T2 correlation MRI

(2021) Chantal M.W. Tax et al.   NEUROIMAGE

The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study

(2020) Tobias D. Faizy et al.   Frontiers in Neuroscience

Age Related Differences in Cerebral Blood Flow and Cortical Thickness with an Application to Age Prediction

(2020) M. Ethan MacDonald et al.   NEUROBIOLOGY OF AGING

Age-Related Changes in Relaxation Times, Proton Density, Myelin, and Tissue Volumes in Adult Brain Analyzed by 2-Dimensional Quantitative Synthetic Magnetic Resonance Imaging

(2020) Akifumi Hagiwara et al.   INVESTIGATIVE RADIOLOGY

Myelin water imaging depends on white matter fiber orientation in the human brain

(2020) Christoph Birkl et al.   MAGNETIC RESONANCE IN MEDICINE

Longitudinal ComBat: A method for harmonizing longitudinal multi-scanner imaging data

(2020) Joanne C. Beer et al.   NEUROIMAGE

Age-related deep white matter changes in myelin and water content: A T2 relaxometry study

(2019) Efrosini Papadaki et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

A novel patch-based procedure for estimating brain age across adulthood

(2019) Iman Beheshti et al.   NEUROIMAGE

Perivascular space fluid contributes to diffusion tensor imaging changes in white matter

(2019) Farshid Sepehrband et al.   NEUROIMAGE

Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity

(2019) Eugene L. Scharf et al.   STROKE

Brain aging and psychometric intelligence: a longitudinal study

(2019) L. Jäncke et al.   Brain Structure & Function

Blood–brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging

(2018) C. Eleana Zhang et al.   Brain Imaging and Behavior

Diffusion tensor imaging and tractography of the white matter in normal aging: The rate-of-change differs between segments within tracts

(2018) J. Mårtensson et al.   MAGNETIC RESONANCE IMAGING

Age-related changes in cerebrovascular reactivity and their relationship to cognition: A four-year longitudinal study

(2018) Shin-Lei Peng et al.   NEUROIMAGE

Interdatabase Variability in Cortical Thickness Measurements

(2018) M Ethan MacDonald et al.   CEREBRAL CORTEX

Establishing intra- and inter-vendor reproducibility of T1 relaxation time measurements with 3T MRI

(2018) Yoojin Lee et al.   MAGNETIC RESONANCE IN MEDICINE

Increased mean R2* in the deep gray matter of multiple sclerosis patients: Have we been measuring atrophy?

(2018) Enedino Hernández-Torres et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Estimating and accounting for the effect of MRI scanner changes on longitudinal whole-brain volume change measurements

(2018) Hyunwoo Lee et al.   NEUROIMAGE

Relationship between aging and T 1 relaxation time in deep gray matter: A voxel-based analysis

(2017) Gosuke Okubo et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

In vivo assessment of iron content of the cerebral cortex in healthy aging using 7-Tesla T2*-weighted phase imaging

(2017) Mathijs Buijs et al.   NEUROBIOLOGY OF AGING

Incident risk and progression of cerebral microbleeds in healthy adults: a multi-occasion longitudinal study

(2017) Ana M. Daugherty et al.   NEUROBIOLOGY OF AGING

Longitudinal association between hippocampus atrophy and episodic-memory decline

(2017) Tetiana Gorbach et al.   NEUROBIOLOGY OF AGING

3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging

(2017) Simona Nikolova et al.   NEUROBIOLOGY OF AGING

Modelling and interpretation of magnetization transfer imaging in the brain

(2017) John G. Sled   NEUROIMAGE

Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker

(2017) James H. Cole et al.   NEUROIMAGE

Lower cardiac index levels relate to lower cerebral blood flow in older adults

(2017) Angela L. Jefferson et al.   NEUROLOGY

Longitudinal Changes in Fiber Tract Integrity in Healthy Aging and Mild Cognitive Impairment: A DTI Follow-Up Study

(2017) Stefan J. Teipel et al.   JOURNAL OF ALZHEIMERS DISEASE

Life-course blood pressure in relation to brain volumes

(2016) Melinda C. Power et al.   Alzheimers & Dementia

The relationship between microvasculature in white matter hyperintensities and cognitive function

(2016) Jianzhong Sun et al.   Brain Imaging and Behavior

Gray Matter Atrophy in the Cerebellum—Evidence of Increased Vulnerability of the Crus and Vermis with Advancing Age

(2016) Teresa Yu et al.   CEREBELLUM

Higher diurnal salivary cortisol levels are related to smaller prefrontal cortex surface area in elderly men and women

(2016) Andreas Stomby et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment

(2016) Dandan Huang et al.   EUROPEAN RADIOLOGY

Association between atrial fibrillation and volumetric magnetic resonance imaging brain measures: Framingham Offspring Study

(2016) Ryan J. Piers et al.   HEART RHYTHM

Age prediction on the basis of brain anatomical measures

(2016) S.A. Valizadeh et al.   HUMAN BRAIN MAPPING

Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults

(2016) Matthew P. Pase et al.   HYPERTENSION

Effects of stressful life events on cerebral white matter hyperintensity progression

(2016) Anne D. Johnson et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Distribution of cardiac output to the brain across the adult lifespan

(2016) Chang-Yang Xing et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aging alters the dampening of pulsatile blood flow in cerebral arteries

(2016) Laleh Zarrinkoob et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of arterial transit delay on cerebral blood flow quantification using arterial spin labeling in an elderly cohort

(2016) Weiying Dai et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan

(2016) J. Acosta-Cabronero et al.   JOURNAL OF NEUROSCIENCE

Mean arterial pressure change associated with cerebral blood flow in healthy older adults

(2016) Jeremy Deverdun et al.   NEUROBIOLOGY OF AGING

Cerebral microbleeds are associated with physical frailty: a community-based study

(2016) Chih-Ping Chung et al.   NEUROBIOLOGY OF AGING

Normative data for subcortical regional volumes over the lifetime of the adult human brain

(2016) Olivier Potvin et al.   NEUROIMAGE

Accumulation of iron in the putamen predicts its shrinkage in healthy older adults: A multi-occasion longitudinal study

(2016) Ana M. Daugherty et al.   NEUROIMAGE

High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R 2 * measurements at 7 T

(2016) Matthew J. Betts et al.   NEUROIMAGE

Use of 3D pseudo-continuous arterial spin labeling to characterize sex and age differences in cerebral blood flow

(2016) Wenjia Liu et al.   NEURORADIOLOGY

The Effect of the APOE Genotype on Individual BrainAGE in Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

(2016) Luise Christine Löwe et al.   PLoS One

White Matter Degeneration with Aging: Longitudinal Diffusion MR Imaging Analysis

(2016) Marius de Groot et al.   RADIOLOGY

Importance of Multimodal MRI in Characterizing Brain Tissue and Its Potential Application for Individual Age Prediction

(2016) Andrea Cherubini et al.   IEEE Journal of Biomedical and Health Informatics

Ideal Cardiovascular Health and Cognitive Aging in the Northern Manhattan Study

(2016) Hannah Gardener et al.   Journal of the American Heart Association

Age‐Related Changes of Normal Cerebral and Cardiac Blood Flow in Children and Adults Aged 7 Months to 61 Years

(2016) Can Wu et al.   Journal of the American Heart Association

SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study

(2015) S. Shams et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Subcortical volumetric changes across the adult lifespan: Subregional thalamic atrophy accounts for age-related sensorimotor performance declines

(2015) Leen Serbruyns et al.   CORTEX

Blood Pressure Is Not Associated With Cerebral Blood Flow in Older PersonsNovelty and Significance

(2015) Jessica C. Foster-Dingley et al.   HYPERTENSION

Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons

(2015) Hazel Mae A Abraham et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Assessing global and regional iron content in deep gray matter as a function of age using susceptibility mapping

(2015) Manju Liu et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Lewy body dementias

(2015) Zuzana Walker et al.   LANCET

White matter hyperintensities, cognitive impairment and dementia: an update

(2015) Niels D. Prins et al.   Nature Reviews Neurology

R2* mapping for brain iron: associations with cognition in normal aging

(2015) Christine Ghadery et al.   NEUROBIOLOGY OF AGING

Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults

(2015) Wei Li et al.   NEUROIMAGE

Changes of individual BrainAGE during the course of the menstrual cycle

(2015) Katja Franke et al.   NEUROIMAGE

Cerebrovascular MRI: a review of state-of-the-art approaches, methods and techniques

(2015) Matthew Ethan MacDonald et al.   NMR IN BIOMEDICINE

Hemisphere, gender and age-related effects on iron deposition in deep gray matter revealed by quantitative susceptibility mapping

(2015) Nan-Jie Gong et al.   NMR IN BIOMEDICINE

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

The epidemiology of silent brain infarction: a systematic review of population-based cohorts

(2014) Jonathon P Fanning et al.   BMC Medicine

Statistical estimation of physiological brain age as a descriptor of senescence rate during adulthood

(2014) Andrei Irimia et al.   Brain Imaging and Behavior

Volume of the hippocampal subfields in healthy adults: differential associations with age and a pro-inflammatory genetic variant

(2014) Naftali Raz et al.   Brain Structure & Function

Cerebral Hemodynamics in Normal Aging: Central Artery Stiffness, Wave Reflection, and Pressure Pulsatility

(2014) Takashi Tarumi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

On the accuracy of T1mapping: Searching for common ground

(2014) Nikola Stikov et al.   MAGNETIC RESONANCE IN MEDICINE

MRI-based myelin water imaging: A technical review

(2014) Eva Alonso-Ortiz et al.   MAGNETIC RESONANCE IN MEDICINE

Structural and functional differences in medial prefrontal cortex underlie distractibility and suppression deficits in ageing

(2014) James Z. Chadick et al.   Nature Communications

Shorter telomere length is linked to brain atrophy and white matter hyperintensities

(2013) Mikael Wikgren et al.   AGE AND AGEING

Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals

(2013) J. Hagemeier et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Do cardiovascular risk factors explain the link between white matter hyperintensities and brain volumes in old age? A population-based study

(2013) R. Wang et al.   EUROPEAN JOURNAL OF NEUROLOGY

Effects of age and sex on the concentrations of glutamate and glutamine in the human brain

(2013) Sven Hädel et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Effects of the use of multiple scanners and of scanner upgrade in longitudinal voxel-based morphometry studies

(2013) Hidemasa Takao et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Vessel-encoded arterial spin labeling (VE-ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance

(2013) Manus J. Donahue et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Pulse wave velocity and flow in the carotid artery versus the aortic arch: Effects of aging

(2013) Eleanore S.J. Kröner et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Estimated maximal and current brain volume predict cognitive ability in old age

(2013) Natalie A. Royle et al.   NEUROBIOLOGY OF AGING

Critical ages in the life course of the adult brain: nonlinear subcortical aging

(2013) Anders M. Fjell et al.   NEUROBIOLOGY OF AGING

Susceptibility-Weighted Imaging is More Reliable Than T2*-Weighted Gradient-Recalled Echo MRI for Detecting Microbleeds

(2013) Ah-Ling Cheng et al.   STROKE

Effect of Normal Aging Versus Hypertension, Abnormal Body Mass Index, and Diabetes Mellitus on White Matter Hyperintensity Volume

(2013) Kevin S. King et al.   STROKE

The Structure of the Cerebral Cortex Across Adult Life: Age-Related Patterns of Surface Area, Thickness, and Gyrification

(2012) Larson J. Hogstrom et al.   CEREBRAL CORTEX

Auditory Cortex Signs of Age-Related Hearing Loss

(2012) Mark A. Eckert et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Brain Energy Metabolism and Blood Flow Differences in Healthy Aging

(2012) Joel Aanerud et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In vivo glutamate measured with magnetic resonance spectroscopy: behavioral correlates in aging

(2012) Natalie M. Zahr et al.   NEUROBIOLOGY OF AGING

Does variability in cognitive performance correlate with frontal brain volume?

(2012) Martin Lövdén et al.   NEUROIMAGE

Age effect on subcortical structures in healthy adults

(2012) Matt Goodro et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Comparison of ESWAN, SWI-SPGR, and 2D T2*-Weighted GRE Sequence for Depicting Cerebral Microbleeds

(2012) L. F. Guo et al.   Clinical Neuroradiology

Cerebral amyloid angiopathy in the elderly

(2011) Anand Viswanathan et al.   ANNALS OF NEUROLOGY

Hypertension, White Matter Hyperintensities, and Concurrent Impairments in Mobility, Cognition, and Mood

(2011) Ihab Hajjar et al.   CIRCULATION

Human brain changes across the life span: A review of 56 longitudinal magnetic resonance imaging studies

(2011) Anna M. Hedman et al.   HUMAN BRAIN MAPPING

Age-related regional brain T2-relaxation changes in healthy adults

(2011) Rajesh Kumar et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics

(2011) Yinan Liu et al.   MAGNETIC RESONANCE IN MEDICINE

MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

(2011) Berkin Bilgic et al.   NEUROIMAGE

Incidence of Cerebral Microbleeds in the General Population

(2011) Mariëlle M.F. Poels et al.   STROKE

The worldwide societal costs of dementia: Estimates for 2009

(2010) Anders Wimo et al.   Alzheimers & Dementia

Functional Impact of White Matter Hyperintensities in Cognitively Normal Elderly Subjects

(2010) Melissa E. Murray et al.   ARCHIVES OF NEUROLOGY

Cardiac Index Is Associated With Brain Aging

(2010) Angela L. Jefferson et al.   CIRCULATION

Longitudinal Study of Callosal Microstructure in the Normal Adult Aging Brain Using Quantitative DTI Fiber Tracking

(2010) Edith V. Sullivan et al.   DEVELOPMENTAL NEUROPSYCHOLOGY

Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults

(2010) E. Mark Haacke et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Clinical Correlating Factors and Cognitive Function in Community-Dwelling Healthy Subjects With Cerebral Microbleeds

(2010) Yuki Takashima et al.   Journal of Stroke & Cerebrovascular Diseases

Selective review of cognitive aging

(2010) TIMOTHY A. SALTHOUSE   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Hippocampal blood flow in normal aging measured with arterial spin labeling at 3T

(2010) Henry Rusinek et al.   MAGNETIC RESONANCE IN MEDICINE

Brain iron deposits are associated with general cognitive ability and cognitive aging

(2010) Lars Penke et al.   NEUROBIOLOGY OF AGING

Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?

(2010) Herve Lemaitre et al.   NEUROBIOLOGY OF AGING

Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: Exploring the influence of various parameters

(2010) Katja Franke et al.   NEUROIMAGE

Age-associated reductions in cerebral blood flow are independent from regional atrophy

(2010) J. Jean Chen et al.   NEUROIMAGE

Hippocampal mean diffusivity and memory in healthy elderly individuals: A cross-sectional study

(2010) G. A. Carlesimo et al.   NEUROLOGY

Counting Cavitating Lacunes Underestimates the Burden of Lacunar Infarction

(2010) Gillian M. Potter et al.   STROKE

Role of Lifestyle and Aging on the Longitudinal Change in Cardiorespiratory Fitness

(2009) Andrew S. Jackson et al.   ARCHIVES OF INTERNAL MEDICINE

Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography

(2009) Khader M. Hasan et al.   BRAIN RESEARCH

Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity

(2009) Jessica S. Damoiseaux et al.   Brain Structure & Function

Decomposing age correlations on neuropsychological and cognitive variables

(2009) TIMOTHY A. SALTHOUSE   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Prevalence, incidence, and risk factors of lacunar infarcts in a community sample

(2009) X. Chen et al.   NEUROLOGY

The Cost of Dementia in Europe

(2009) Linus Jönsson et al.   PHARMACOECONOMICS

Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging

(2009) Adam M. Brickman et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Age-related Degradation in the Central Nervous System: Assessment with Diffusion-Tensor Imaging and Quantitative Fiber Tracking

(2009) Andreas Stadlbauer et al.   RADIOLOGY

Large Artery Stiffening as a Link Between Cerebral Lacunar Infarction and Renal Albuminuria

(2008) J. Hashimoto et al.   AMERICAN JOURNAL OF HYPERTENSION

Reproducibility, Interrater Agreement, and Age-Related Changes of Fractional Anisotropy Measures at 3T in Healthy Subjects: Effect of the Applied b-Value

(2008) S. Bisdas et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan

(2008) Khader M. Hasan et al.   BRAIN RESEARCH

Diffusion tensor tractography quantification of the human corpus callosum fiber pathways across the lifespan

(2008) Khader M. Hasan et al.   BRAIN RESEARCH

Low Striatal Glutamate Levels Underlie Cognitive Decline in the Elderly: Evidence from In Vivo Molecular Spectroscopy

(2008) N. M. Zahr et al.   CEREBRAL CORTEX

White matter hyperintensities in the forties: Their prevalence and topography in an epidemiological sample aged 44-48

(2008) Wei Wen et al.   HUMAN BRAIN MAPPING

Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI

(2008) Francesca Schiavone et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

The effects of healthy aging on intracerebral blood vessels visualized by magnetic resonance angiography

(2008) Elizabeth Bullitt et al.   NEUROBIOLOGY OF AGING

Tract shape modelling provides evidence of topological change in corpus callosum genu during normal ageing

(2008) Mark E. Bastin et al.   NEUROIMAGE

Diffusion tensor quantification of the macrostructure and microstructure of human midsagittal corpus callosum across the lifespan

(2008) Khader M. Hasan et al.   NMR IN BIOMEDICINE

Region-specific changes of cerebral white matter during normal aging: A diffusion-tensor analysis

(2007) Bora Yoon et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Regional variations and the effects of age and gender on glutamate concentrations in the human brain

(2007) Napapon Sailasuta et al.   MAGNETIC RESONANCE IMAGING

Gender differences and age-related white matter changes of the human brain: A diffusion tensor imaging study

(2007) Jung-Lung Hsu et al.   NEUROIMAGE

Age, gender, and hemispheric differences in iron deposition in the human brain: An in vivo MRI study

(2007) Xiaojun Xu et al.   NEUROIMAGE