Journal
AGE AND AGEING
Volume 43, Issue 2, Pages 212-217Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ageing/aft172
Keywords
brain atrophy; older people; telomere length; white matter hyperintensities
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Funding
- Swedish Research Council [2006-4472, 2009-5269, 2009-3413, 345-2003-3883, 315-2004-6977]
- Medical Faculty, Umea University
- County Council of Vasterbotten, Sweden
- County Council of Norrbotten, Sweden
- Bank of Sweden Tercentenary Foundation
- Swedish Council for Planning and Coordination of Research
- Swedish Council for Research in the Humanities and Social Sciences
- Swedish Council for Social Research
- European Union Directorate General XII
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Background: leukocyte telomere length (TL) is considered a marker of biological aging. Several studies have investigated the link between leukocyte TL and aging-associated functional attributes of the brain, but no prior study has investigated whether TL can be linked to brain atrophy and white matter hyperintensities (WMHs); two prominent structural manifestations of brain aging. Methods: we investigated whether leukocyte TL was related to brain atrophy and WMHs in a sample of 102 non-demented individuals aged 64-75 years. Results: shorter TL was related to greater degree of subcortical atrophy (beta = -0.217, P = 0.034), but not to cortical atrophy. Furthermore, TL was 371 bp shorter (P = 0.041) in participants exhibiting subcortical WMHs, and 552 bp shorter (P = 0.009) in older participants exhibiting periventricular WMHs. Conclusion: this study provides the first evidence of leukocyte TL being associated with cerebral subcortical atrophy and WMHs, lending further support to the concept of TL as a marker of biological aging, and in particular that of the aging brain.
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