The Roles of Tetramethylpyrazine During Neurodegenerative Disease

The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease

(2021) Guiliang Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

(2021) Emma Gerrits et al.   ACTA NEUROPATHOLOGICA

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease

(2021) Aihong Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease

(2021) Xianfeng Huang et al.   Frontiers in Cell and Developmental Biology

A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer’s Disease

(2020) Wenyong Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ligustrazine ameliorates lipopolysaccharide‑induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway

(2020) Guangming Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson’s disease models through activating the MEF2-PGC1α and BDNF/CREB pathways

(2020) Haiyun Chen et al.   Aging-US

MEF2D upregulation protects neurons from oxygen–glucose deprivation/re-oxygenation-induced injury by enhancing Nrf2 activation

(2020) Nan Wang et al.   BRAIN RESEARCH

Tetramethylpyrazine ameliorates isoflurane‑induced cognitive dysfunction by inhibiting neuroinflammation via miR‑150 in rats

(2020) Huaqing Cui et al.   Experimental and Therapeutic Medicine

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

(2020) Marta Pajares et al.   Cells

Phase I safety, tolerability, and pharmacokinetic studies of tetramethylpyrazine nitrone in healthy Chinese volunteers

(2020) Caiyun Zhao et al.   DRUG DEVELOPMENT RESEARCH

Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice

(2020) Jing Wen et al.   NEUROPHARMACOLOGY

The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis

(2019) Lu Yu et al.   Frontiers in Pharmacology

Panax ginseng components and the pathogenesis of Alzheimer's disease (Review)

(2019) Mayya Razgonova et al.   Molecular Medicine Reports

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

(2019) Shouliang Wang et al.   Drug Design Development and Therapy

Effects of miR-150 on neuropathic pain process via targeting AKT3

(2019) Wei Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models

(2019) Hefeng Zhou et al.   Neurotherapeutics

Doença de Parkinson: Revisão Clínica e Atualização

(2019) Verónica Cabreira et al.   Acta Medica Portuguesa

Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson’s Disease In Vitro and In Vivo

(2019) Hefeng Zhou et al.   Oxidative Medicine and Cellular Longevity

Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson’s Disease

(2019) Li-Yuan Wang et al.   Frontiers in Aging Neuroscience

Neuroprotective activity of tetramethylpyrazine against 3-nitropropionic acid induced Huntington’s disease-like symptoms in rats

(2018) Ravi Chandra Sekhara Reddy Danduga et al.   BIOMEDICINE & PHARMACOTHERAPY

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Synthesis and activity towards Alzheimer's disease in vitro : Tacrine, phenolic acid and ligustrazine hybrids

(2018) Guoliang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage

(2018) Zhengkai Shao et al.   NEUROCHEMICAL RESEARCH

VDAC1, mitochondrial dysfunction, and Alzheimer's disease

(2018) Varda Shoshan-Barmatz et al.   PHARMACOLOGICAL RESEARCH

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

(2018) Shengquan Hu et al.   Frontiers in Pharmacology

Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

(2018) Estella A. Newcombe et al.   Journal of Neuroinflammation

A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

(2018) Haiyun Chen et al.   Frontiers in Neuroscience

Synthesis and Evaluation of Novel Ligustrazine Derivatives as Multi-Targeted Inhibitors for the Treatment of Alzheimer’s Disease

(2018) Wenhao Wu et al.   MOLECULES

Huntington's disease: a clinical review

(2017) P. McColgan et al.   EUROPEAN JOURNAL OF NEUROLOGY

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

MiR-150 alleviates neuropathic pain via inhibiting toll-like receptor 5

(2017) Li-Juan Ji et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tetramethylpyrazine nitrone protects retinal ganglion cells against N -methyl-d -aspartate-induced excitotoxicity

(2017) Xiaopeng Luo et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNAs: Roles in Regulating Neuroinflammation

(2017) Andrew D. Gaudet et al.   NEUROSCIENTIST

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

(2017) Michael G. Erkkinen et al.   Cold Spring Harbor Perspectives in Biology

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson’s Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions

(2016) Haidy E. Michel et al.   MOLECULAR NEUROBIOLOGY

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine

(2016) Shengquan Hu et al.   NEUROMOLECULAR MEDICINE

Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated fromRhizoma Chuanxiong): Roles and Mechanisms

(2016) Ming Guo et al.   Biomed Research International

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

(2015) Hai-Yun Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tetramethylpyrazine inhibits CoCl2-induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

(2015) Dongsheng Guan et al.   JOURNAL OF NEUROCHEMISTRY

Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications

(2015) Islem Younes et al.   Marine Drugs

Expression and phosphorylation of glutamate receptor subunits and CaMKII in a mouse model of Parkinsonism

(2014) Maria Koutsokera et al.   BRAIN RESEARCH

Neuroprotective Effects of Tetramethylpyrazine against Dopaminergic Neuron Injury in a Rat Model of Parkinson's Disease Induced by MPTP

(2014) Chen Lu et al.   International Journal of Biological Sciences

Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson’s disease

(2014) Hong Zhao et al.   NEUROLOGICAL SCIENCES

Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration

(2014) Dongmei Meng et al.   Acta Pharmaceutica Sinica B

Therapeutic Effects of Multifunctional Tetramethylpyrazine Nitrone on Models of Parkinson’s Disease in Vitro and in Vivo

(2013) Baojian Guo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A Tetramethylpyrazine Piperazine Derivate CXC137 Prevents Cell Injury in SH-SY5Y Cells and Improves Memory Dysfunction of Rats with Vascular Dementia

(2013) Hao Zhang et al.   NEUROCHEMICAL RESEARCH

Ligustrazine Phosphate Ethosomes for Treatment of Alzheimer’s Disease, In Vitro and in Animal Model Studies

(2012) Jun Shi et al.   AAPS PHARMSCITECH